Open-label tofacitinib and double-blind atorvastatin in rheumatoid arthritis patients: a randomised study

Objectives To evaluate the efficacy and safety of atorvastatin versus placebo in modifying lipids in patients with rheumatoid arthritis (RA) receiving the oral Janus kinase inhibitor, tofacitinib. Methods A randomised, placebo controlled, multicentre phase 2 study, open-label for tofacitinib and bli...

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Veröffentlicht in:	Annals of the rheumatic diseases 2014-01, Vol.73 (1), p.124-131
Hauptverfasser:	McInnes, Iain B, Kim, Ho-Youn, Lee, Sang-Heon, Mandel, David, Song, Yeong-Wook, Connell, Carol A, Luo, Zhen, Brosnan, M Julia, Zuckerman, Andrea, Zwillich, Samuel H, Bradley, John D
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - drug therapy Atorvastatin Calcium Cardiovascular Diseases - complications Cardiovascular Diseases - drug therapy Cholesterol Cytokines Disease Double-Blind Method Drug dosages Drug Therapy, Combination Family medical history Female Follow-Up Studies Heptanoic Acids - administration & dosage Heptanoic Acids - adverse effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Lipids Lipids - blood Low density lipoprotein Male Middle Aged Mortality Neutrophils Piperidines - administration & dosage Piperidines - adverse effects Placebos Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects Pyrimidines - administration & dosage Pyrimidines - adverse effects Pyrroles - administration & dosage Pyrroles - adverse effects Rheumatoid arthritis Studies Treatment Outcome
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