Oncolytic adenovirus encoding tumor necrosis factor-related apoptosis inducing ligand (TRAIL) inhibits the growth and metastasis of triple-negative breast cancer
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a promising cancer therapeutic target due to its selective apoptosis-inducing effect in cancer cells. To efficiently deliver TRAIL to the tumor cells, an oncolytic adenovirus (p55-hTERT-HRE-TRAIL) carrying the TRAIL coding sequence w...
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| Veröffentlicht in: | Cancer biology & therapy 2013-11, Vol.14 (11), p.1016-1023 |
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| creator | Zhu, Wei Zhang, Hongwei Shi, Yi Song, Mangen Zhu, Bijun Wei, Lai |
| description | Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a promising cancer therapeutic target due to its selective apoptosis-inducing effect in cancer cells. To efficiently deliver TRAIL to the tumor cells, an oncolytic adenovirus (p55-hTERT-HRE-TRAIL) carrying the TRAIL coding sequence was constructed. In the present study, we aimed to investigate the effect of p55-hTERT-HRE-TRAIL on the growth and metastasis of triple-negative breast cancer (TNBC). We observed that infection of the recombinant adenovirus resulted in expression of TRAIL and massive cell death in a TNBC cell line MDA-MB-231. This effect is much weaker in MCF-10A, which is a normal breast cell line. Administration of P55-HTERT-HRE-TRAIL significantly reduced orthotopic breast tumor growth and extended survival in a metastatic model. Our results suggest the oncolytic adenovirus armed with P55-HTERT-HRE-TRAIL, which exhibited enhanced anti-tumor activity and improved survival, is a promising candidate for virotherapy of TNBC. |
| doi_str_mv | 10.4161/cbt.26043 |
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To efficiently deliver TRAIL to the tumor cells, an oncolytic adenovirus (p55-hTERT-HRE-TRAIL) carrying the TRAIL coding sequence was constructed. In the present study, we aimed to investigate the effect of p55-hTERT-HRE-TRAIL on the growth and metastasis of triple-negative breast cancer (TNBC). We observed that infection of the recombinant adenovirus resulted in expression of TRAIL and massive cell death in a TNBC cell line MDA-MB-231. This effect is much weaker in MCF-10A, which is a normal breast cell line. Administration of P55-HTERT-HRE-TRAIL significantly reduced orthotopic breast tumor growth and extended survival in a metastatic model. Our results suggest the oncolytic adenovirus armed with P55-HTERT-HRE-TRAIL, which exhibited enhanced anti-tumor activity and improved survival, is a promising candidate for virotherapy of TNBC.</description><identifier>ISSN: 1538-4047</identifier><identifier>EISSN: 1555-8576</identifier><identifier>DOI: 10.4161/cbt.26043</identifier><identifier>PMID: 24025362</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Adenoviridae - genetics ; Adenoviridae - physiology ; adenovirus ; Apoptosis ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Ductal, Breast - therapy ; Female ; Humans ; Neoplasm Metastasis ; Oncolytic Virotherapy ; Oncolytic Viruses - genetics ; Oncolytic Viruses - physiology ; Research Paper ; TNF-Related Apoptosis-Inducing Ligand - genetics ; TNF-Related Apoptosis-Inducing Ligand - metabolism ; Triple Negative Breast Neoplasms - pathology ; Triple Negative Breast Neoplasms - therapy ; triple-negative breast cancer (TNBC) ; tumor necrosis factor-related apoptosis inducing ligand (TRAIL) ; virotherapy</subject><ispartof>Cancer biology & therapy, 2013-11, Vol.14 (11), p.1016-1023</ispartof><rights>Copyright © 2013 Landes Bioscience 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-ad06ac6bbf1919499560d31168a41df295fdf2ae4f349f0ad7dce32373f656443</citedby><cites>FETCH-LOGICAL-c420t-ad06ac6bbf1919499560d31168a41df295fdf2ae4f349f0ad7dce32373f656443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925656/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925656/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24025362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Wei</creatorcontrib><creatorcontrib>Zhang, Hongwei</creatorcontrib><creatorcontrib>Shi, Yi</creatorcontrib><creatorcontrib>Song, Mangen</creatorcontrib><creatorcontrib>Zhu, Bijun</creatorcontrib><creatorcontrib>Wei, Lai</creatorcontrib><title>Oncolytic adenovirus encoding tumor necrosis factor-related apoptosis inducing ligand (TRAIL) inhibits the growth and metastasis of triple-negative breast cancer</title><title>Cancer biology & therapy</title><addtitle>Cancer Biol Ther</addtitle><description>Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a promising cancer therapeutic target due to its selective apoptosis-inducing effect in cancer cells. To efficiently deliver TRAIL to the tumor cells, an oncolytic adenovirus (p55-hTERT-HRE-TRAIL) carrying the TRAIL coding sequence was constructed. In the present study, we aimed to investigate the effect of p55-hTERT-HRE-TRAIL on the growth and metastasis of triple-negative breast cancer (TNBC). We observed that infection of the recombinant adenovirus resulted in expression of TRAIL and massive cell death in a TNBC cell line MDA-MB-231. This effect is much weaker in MCF-10A, which is a normal breast cell line. Administration of P55-HTERT-HRE-TRAIL significantly reduced orthotopic breast tumor growth and extended survival in a metastatic model. Our results suggest the oncolytic adenovirus armed with P55-HTERT-HRE-TRAIL, which exhibited enhanced anti-tumor activity and improved survival, is a promising candidate for virotherapy of TNBC.</description><subject>Adenoviridae - genetics</subject><subject>Adenoviridae - physiology</subject><subject>adenovirus</subject><subject>Apoptosis</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Ductal, Breast - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Neoplasm Metastasis</subject><subject>Oncolytic Virotherapy</subject><subject>Oncolytic Viruses - genetics</subject><subject>Oncolytic Viruses - physiology</subject><subject>Research Paper</subject><subject>TNF-Related Apoptosis-Inducing Ligand - genetics</subject><subject>TNF-Related Apoptosis-Inducing Ligand - metabolism</subject><subject>Triple Negative Breast Neoplasms - pathology</subject><subject>Triple Negative Breast Neoplasms - therapy</subject><subject>triple-negative breast cancer (TNBC)</subject><subject>tumor necrosis factor-related apoptosis inducing ligand (TRAIL)</subject><subject>virotherapy</subject><issn>1538-4047</issn><issn>1555-8576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkctq3DAUhk1padK0i75A0TJZONXd400hhF4CA4GSroWsi0dFllxJnjCPkzetnElDS0FI4vzf-SXO3zTvEbykiKOPaiiXmENKXjSniDHWbljHX653smkppN1J8ybnnxDiDvP-dXOCKcSMcHzaPNwGFf2hOAWkNiHuXVoyMLWoXRhBWaaYQDAqxewysFKVmNpkvCxGAznHuTwKLuhFrQ3ejTJocH73_epme1HrOze4kkHZGTCmeF92YNUnU2Suq7ZGC0pyszdtMKMsbm_AkExVgZJBmfS2eWWlz-bd03nW_Pjy-e76W7u9_XpzfbVtFcWwtFJDLhUfBot61NO-ZxxqghDfSIq0xT2zdZeGWkJ7C6XutDIEk45Yzjil5Kz5dPSdl2EyVQwlSS_m5CaZDiJKJ_5VgtuJMe4F6TGrFtXg_MkgxV-LyUVMLivjvQwmLlkgytmGE0RhRS-O6DrXnIx9fgZBsUYqaqTiMdLKfvj7X8_knwwrQI-ACzamSd7H5LUo8uBjsqnO0GVB_vf9DU40s6o</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Zhu, Wei</creator><creator>Zhang, Hongwei</creator><creator>Shi, Yi</creator><creator>Song, Mangen</creator><creator>Zhu, Bijun</creator><creator>Wei, Lai</creator><general>Taylor & Francis</general><general>Landes Bioscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201311</creationdate><title>Oncolytic adenovirus encoding tumor necrosis factor-related apoptosis inducing ligand (TRAIL) inhibits the growth and metastasis of triple-negative breast cancer</title><author>Zhu, Wei ; Zhang, Hongwei ; Shi, Yi ; Song, Mangen ; Zhu, Bijun ; Wei, Lai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-ad06ac6bbf1919499560d31168a41df295fdf2ae4f349f0ad7dce32373f656443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenoviridae - genetics</topic><topic>Adenoviridae - physiology</topic><topic>adenovirus</topic><topic>Apoptosis</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Ductal, Breast - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Neoplasm Metastasis</topic><topic>Oncolytic Virotherapy</topic><topic>Oncolytic Viruses - genetics</topic><topic>Oncolytic Viruses - physiology</topic><topic>Research Paper</topic><topic>TNF-Related Apoptosis-Inducing Ligand - genetics</topic><topic>TNF-Related Apoptosis-Inducing Ligand - metabolism</topic><topic>Triple Negative Breast Neoplasms - pathology</topic><topic>Triple Negative Breast Neoplasms - therapy</topic><topic>triple-negative breast cancer (TNBC)</topic><topic>tumor necrosis factor-related apoptosis inducing ligand (TRAIL)</topic><topic>virotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Wei</creatorcontrib><creatorcontrib>Zhang, Hongwei</creatorcontrib><creatorcontrib>Shi, Yi</creatorcontrib><creatorcontrib>Song, Mangen</creatorcontrib><creatorcontrib>Zhu, Bijun</creatorcontrib><creatorcontrib>Wei, Lai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer biology & therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Wei</au><au>Zhang, Hongwei</au><au>Shi, Yi</au><au>Song, Mangen</au><au>Zhu, Bijun</au><au>Wei, Lai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oncolytic adenovirus encoding tumor necrosis factor-related apoptosis inducing ligand (TRAIL) inhibits the growth and metastasis of triple-negative breast cancer</atitle><jtitle>Cancer biology & therapy</jtitle><addtitle>Cancer Biol Ther</addtitle><date>2013-11</date><risdate>2013</risdate><volume>14</volume><issue>11</issue><spage>1016</spage><epage>1023</epage><pages>1016-1023</pages><issn>1538-4047</issn><eissn>1555-8576</eissn><abstract>Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a promising cancer therapeutic target due to its selective apoptosis-inducing effect in cancer cells. To efficiently deliver TRAIL to the tumor cells, an oncolytic adenovirus (p55-hTERT-HRE-TRAIL) carrying the TRAIL coding sequence was constructed. In the present study, we aimed to investigate the effect of p55-hTERT-HRE-TRAIL on the growth and metastasis of triple-negative breast cancer (TNBC). We observed that infection of the recombinant adenovirus resulted in expression of TRAIL and massive cell death in a TNBC cell line MDA-MB-231. This effect is much weaker in MCF-10A, which is a normal breast cell line. Administration of P55-HTERT-HRE-TRAIL significantly reduced orthotopic breast tumor growth and extended survival in a metastatic model. 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| subjects | Adenoviridae - genetics Adenoviridae - physiology adenovirus Apoptosis Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - therapy Female Humans Neoplasm Metastasis Oncolytic Virotherapy Oncolytic Viruses - genetics Oncolytic Viruses - physiology Research Paper TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - metabolism Triple Negative Breast Neoplasms - pathology Triple Negative Breast Neoplasms - therapy triple-negative breast cancer (TNBC) tumor necrosis factor-related apoptosis inducing ligand (TRAIL) virotherapy |
| title | Oncolytic adenovirus encoding tumor necrosis factor-related apoptosis inducing ligand (TRAIL) inhibits the growth and metastasis of triple-negative breast cancer |
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