Measuring T cell receptor and T cell gene expression diversity in antigen-responsive human CD4+ T cells

T cells have diversity in TCR, epitope recognition, and cytokine production, and can be used for immune monitoring. Furthermore, clonal expansion of TCR families in disease may provide opportunities for TCR-directed therapies. We developed methodology for sequencing expressed genes of TCR alpha and...

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Veröffentlicht in:	Journal of immunological methods 2013-12, Vol.400-401, p.13-22
Hauptverfasser:	Eugster, Anne, Lindner, Annett, Heninger, Anne-Kristin, Wilhelm, Carmen, Dietz, Sevina, Catani, Mara, Ziegler, Anette-G., Bonifacio, Ezio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology cytokines DNA - genetics epitopes Female Gene expression Gene Expression Profiling - methods genes Human Humans Immunologic Memory Infant Male Middle Aged monitoring receptors Receptors, Antigen, T-Cell, alpha-beta - genetics secondary immunization Sequence Analysis, DNA - methods Single-Cell Analysis - methods T cell receptor T cells T-Lymphocyte Subsets - immunology tetanus Tetanus Toxoid - immunology vaccination vaccines
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