Phosphoinositide 3‐kinases as accelerators and brakes of autophagy

Degradation of cytoplasmic material by autophagy plays a key role in protein homeostasis and metabolic control, as well as in the removal of intracellular protein aggregates, pathogens and damaged organelles. The concept of up‐ or down‐regulating this pathway pharmacologically in neurodegenerative d...

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Veröffentlicht in:	The FEBS journal 2013-12, Vol.280 (24), p.6322-6337
Hauptverfasser:	O′Farrell, Fergal, Rusten, Tor E., Stenmark, Harald
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Beclin Humans Kinases Pharmacology Phosphatidylinositol 3-Kinases - metabolism PIK3C3 PIK3CA Proteins Signal Transduction TORC1 Tumors
Online-Zugang:	Volltext
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