Regulation of deubiquitinase proteolytic activity

•Phosphorylation of USP1 leads to binding of allosteric activator UAF1.•Activation of DUBA by a single phosphorylation event.•Allosteric activation of USP7 by binding to GMPS.•Active UBP8 stabilized by SAGA DUB module subunits.•Reversible inactivation of DUBs by ROS through sulfenic acid formation....

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Veröffentlicht in:	Current opinion in structural biology 2013-12, Vol.23 (6), p.806-811
Hauptverfasser:	Huang, Oscar W, Cochran, Andrea G
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Animals Biocatalysis Humans Protein Processing, Post-Translational Proteolysis Reactive Oxygen Species - metabolism Ubiquitin-Specific Proteases - chemistry Ubiquitin-Specific Proteases - metabolism
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