Development of calcium pectinate-tamarind seed polysaccharide mucoadhesive beads containing metformin HCl

•Novel mucoadhesive beads of metformin HCl was developed and optimized.•Low methoxy (LM) pectin-tamarind seed polysaccharide polymer-blend was used.•The in vitro drug release followed zero-order with super case-II transport mechanism.•The optimized beads showed pH-sensitive swelling and good mucoadh...

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Veröffentlicht in:	Carbohydrate polymers 2014-01, Vol.101, p.220-230
Hauptverfasser:	Nayak, Amit Kumar, Pal, Dilipkumar, Santra, Kousik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesiveness Animals Applied sciences Biological and medical sciences Controlled drug release Drug Carriers - chemistry Drug Carriers - metabolism Exact sciences and technology Female General and cellular metabolism. Vitamins Intestinal Mucosa - metabolism Ionotropic-gelation Male Medical sciences Metformin - chemistry Metformin - pharmacology Metformin HCl Microspheres Mucoadhesion Natural polymers Pectin Pectins - chemistry Pharmacology. Drug treatments Physicochemistry of polymers Rats Seeds - chemistry Starch and polysaccharides Tamarind seed polysaccharide Tamarindus - chemistry
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