Plzf as a candidate gene predisposing the spontaneously hypertensive rat to hypertension, left ventricular hypertrophy, and interstitial fibrosis

The spontaneously hypertensive rat (SHR) is the most widely used model of essential hypertension and is susceptible to left ventricular hypertrophy (LVH) and myocardial fibrosis. Recently, a quantitative trait locus (QTL) that influences heart interstitial fibrosis was mapped to chromosome 8. Our ai...

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Veröffentlicht in:	American journal of hypertension 2014-01, Vol.27 (1), p.99-106
Hauptverfasser:	Liška, František, Mancini, Massimiliano, Krupková, Michaela, Chylíková, Blanka, Křenová, Drahomíra, Šeda, Ondřej, Šilhavý, Jan, Mlejnek, Petr, Landa, Vladimír, Zídek, Václav, d' Amati, Giulia, Pravenec, Michal, Křen, Vladimír
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Congenic Blood pressure Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fibrosis Gene Expression Regulation Genes Genetic Association Studies Genetic Predisposition to Disease Hemodynamics - genetics Hypertension Hypertension - genetics Hypertension - metabolism Hypertension - physiopathology Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - metabolism Hypertrophy, Left Ventricular - physiopathology Male Myocardium - pathology Phenotype Promyelocytic Leukemia Zinc Finger Protein Quantitative Trait Loci Rats Rats, Inbred SHR Rodents Time Factors
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