Physiological roles of Rho and Rho effectors in mammals

Rho GTPase is a master regulator controlling cytoskeleton in multiple contexts such as cell migration, adhesion and cytokinesis. Of several Rho GTPases in mammals, the best characterized is the Rho subfamily including ubiquitously expressed RhoA and its homologs RhoB and RhoC. Upon binding GTP, Rho...

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Veröffentlicht in:	European journal of cell biology 2013-10, Vol.92 (10-11), p.303-315
Hauptverfasser:	Thumkeo, Dean, Watanabe, Sadanori, Narumiya, Shuh
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin cytoskeleton Adaptor Proteins, Signal Transducing - metabolism Animals Carrier Proteins - metabolism Citron Humans Intracellular Signaling Peptides and Proteins - metabolism Knockout mouse mDia Mice Mice, Knockout PKN Protein Kinase C - metabolism Protein-Serine-Threonine Kinases - metabolism Rho Rho effectors rho GTP-Binding Proteins - genetics rho GTP-Binding Proteins - metabolism rho-Associated Kinases - metabolism Rhophilin Rhotekin ROCK
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