miRNA-95 Mediates Radioresistance in Tumors by Targeting the Sphingolipid Phosphatase SGPP1

Radiation resistance poses a major clinical challenge in cancer treatment, but little is known about how microRNA (miR) may regulate this phenomenon. In this study, we used next-generation sequencing to perform an unbiased comparison of miR expression in PC3 prostate cancer cells rendered resistant...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2013-12, Vol.73 (23), p.6972-6986
Hauptverfasser:	XIAOYONG HUANG, TAEB, Samira, BRISTOW, Robert G, LIU, Fei-Fei, LIU, Stanley K, JAHANGIRI, Sahar, EMMENEGGER, Urban, TRAN, Elisa, BRUCE, Jeff, MESCI, Aruz, KORPELA, Elina, VESPRINI, Danny, SHUN WONG, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Line, Tumor Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Male Medical sciences Membrane Proteins - genetics Mice Mice, Nude MicroRNAs - physiology Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Invasiveness Neoplasms - genetics Neoplasms - pathology Pharmacology. Drug treatments Phosphoric Monoester Hydrolases - genetics Radiation Tolerance - genetics RNA Interference Tumors
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