VGKC-complex/LGI1-antibody encephalitis: Clinical manifestations and response to immunotherapy
Abstract Leucine-rich glioma inactivated 1 (LGI1) was recently identified as a target protein in autoimmune synaptic encephalitis, a rare condition associated with autoantibodies against structures in the neuronal synapse. Studies dealing with LGI1 are small in number and the various outcomes of dif...
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| Veröffentlicht in: | Journal of neuroimmunology 2013-12, Vol.265 (1), p.75-81 |
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| creator | Shin, Yong-Won Lee, Soon-Tae Shin, Jung-Won Moon, Jangsup Lim, Jung-Ah Byun, Jung-Ick Kim, Tae-Joon Lee, Keon-Joo Kim, Young-Su Park, Kyung-Il Jung, Keun-Hwa Lee, Sang Kun Chu, Kon |
| description | Abstract Leucine-rich glioma inactivated 1 (LGI1) was recently identified as a target protein in autoimmune synaptic encephalitis, a rare condition associated with autoantibodies against structures in the neuronal synapse. Studies dealing with LGI1 are small in number and the various outcomes of different therapeutic regimens are not well studied. Here, we analyzed clinical characteristics of 14 patients with LGI1 antibodies, and outcomes according to therapeutic strategies. Most patients exhibited abnormal brain positron emission tomography and that patients treated with steroids alone were more likely to relapse and had less favorable outcomes than those treated with steroids and intravenous immunoglobulins. |
| doi_str_mv | 10.1016/j.jneuroim.2013.10.005 |
| format | Article |
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Studies dealing with LGI1 are small in number and the various outcomes of different therapeutic regimens are not well studied. Here, we analyzed clinical characteristics of 14 patients with LGI1 antibodies, and outcomes according to therapeutic strategies. Most patients exhibited abnormal brain positron emission tomography and that patients treated with steroids alone were more likely to relapse and had less favorable outcomes than those treated with steroids and intravenous immunoglobulins.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2013.10.005</identifier><identifier>PMID: 24176648</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Allergy and Immunology ; Antibodies - blood ; Autoantibodies - blood ; Brain - diagnostic imaging ; Brain - metabolism ; Brain - pathology ; Brain Diseases - blood ; Brain Diseases - diagnostic imaging ; Brain Diseases - immunology ; Brain Diseases - therapy ; Electroencephalography ; Encephalitis ; Female ; Fluorodeoxyglucose F18 ; Hashimoto Disease - blood ; Hashimoto Disease - diagnostic imaging ; Hashimoto Disease - immunology ; Hashimoto Disease - therapy ; Humans ; Immunoglobulins, Intravenous - therapeutic use ; Immunotherapy ; Immunotherapy - methods ; LGI1 ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurology ; Positron-Emission Tomography ; Proteins - immunology ; Treatment Outcome</subject><ispartof>Journal of neuroimmunology, 2013-12, Vol.265 (1), p.75-81</ispartof><rights>Elsevier B.V.</rights><rights>2013 Elsevier B.V.</rights><rights>2013.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-8cf30efd9eb782a03a1a0f00dac84da9aa717da3f0217e948894e23edaf9b763</citedby><cites>FETCH-LOGICAL-c489t-8cf30efd9eb782a03a1a0f00dac84da9aa717da3f0217e948894e23edaf9b763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165572813002865$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24176648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Yong-Won</creatorcontrib><creatorcontrib>Lee, Soon-Tae</creatorcontrib><creatorcontrib>Shin, Jung-Won</creatorcontrib><creatorcontrib>Moon, Jangsup</creatorcontrib><creatorcontrib>Lim, Jung-Ah</creatorcontrib><creatorcontrib>Byun, Jung-Ick</creatorcontrib><creatorcontrib>Kim, Tae-Joon</creatorcontrib><creatorcontrib>Lee, Keon-Joo</creatorcontrib><creatorcontrib>Kim, Young-Su</creatorcontrib><creatorcontrib>Park, Kyung-Il</creatorcontrib><creatorcontrib>Jung, Keun-Hwa</creatorcontrib><creatorcontrib>Lee, Sang Kun</creatorcontrib><creatorcontrib>Chu, Kon</creatorcontrib><title>VGKC-complex/LGI1-antibody encephalitis: Clinical manifestations and response to immunotherapy</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Leucine-rich glioma inactivated 1 (LGI1) was recently identified as a target protein in autoimmune synaptic encephalitis, a rare condition associated with autoantibodies against structures in the neuronal synapse. Studies dealing with LGI1 are small in number and the various outcomes of different therapeutic regimens are not well studied. Here, we analyzed clinical characteristics of 14 patients with LGI1 antibodies, and outcomes according to therapeutic strategies. Most patients exhibited abnormal brain positron emission tomography and that patients treated with steroids alone were more likely to relapse and had less favorable outcomes than those treated with steroids and intravenous immunoglobulins.</description><subject>Adult</subject><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Antibodies - blood</subject><subject>Autoantibodies - blood</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain Diseases - blood</subject><subject>Brain Diseases - diagnostic imaging</subject><subject>Brain Diseases - immunology</subject><subject>Brain Diseases - therapy</subject><subject>Electroencephalography</subject><subject>Encephalitis</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Hashimoto Disease - blood</subject><subject>Hashimoto Disease - diagnostic imaging</subject><subject>Hashimoto Disease - immunology</subject><subject>Hashimoto Disease - therapy</subject><subject>Humans</subject><subject>Immunoglobulins, Intravenous - therapeutic use</subject><subject>Immunotherapy</subject><subject>Immunotherapy - methods</subject><subject>LGI1</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Positron-Emission Tomography</subject><subject>Proteins - immunology</subject><subject>Treatment Outcome</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuP0zAQgC0EYsvCX1jlyCVdv5I4HBCogrKiEgdWHLGm9kTrkNjBThD99zhqlwMXTrZG37y-IeSG0S2jrL7tt73HJQY3bjllIge3lFZPyIaphpdKcvaUbDJYlVXD1RV5kVJPKauEbJ-TKy5ZU9dSbcj3b_vPu9KEcRrw9-1hf8dK8LM7Bnsq0BucHmBws0tvit3gvDMwFCN412GaYXbBpwK8LSKmKf-xmEPhxnHxYX7ACNPpJXnWwZDw1eW9JvcfP9zvPpWHL_u73ftDaaRq51KZTlDsbIvHRnGgAhjQjlILRkkLLUDDGguio5w12EqlWolcoIWuPTa1uCavz2WnGH4ueTY9umRwGMBjWJJmMi_bMsVERuszamJIKWKnp-hGiCfNqF7V6l4_qtWr2jWe1ebEm0uP5Tii_Zv26DID784A5kV_OYw6Gbc6tC6imbUN7v893v5Twlys_8ATpj4s0WeNmunENdVf1wOv92WCUq7qSvwBqtqkhg</recordid><startdate>20131215</startdate><enddate>20131215</enddate><creator>Shin, Yong-Won</creator><creator>Lee, Soon-Tae</creator><creator>Shin, Jung-Won</creator><creator>Moon, Jangsup</creator><creator>Lim, Jung-Ah</creator><creator>Byun, Jung-Ick</creator><creator>Kim, Tae-Joon</creator><creator>Lee, Keon-Joo</creator><creator>Kim, Young-Su</creator><creator>Park, Kyung-Il</creator><creator>Jung, Keun-Hwa</creator><creator>Lee, Sang Kun</creator><creator>Chu, Kon</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131215</creationdate><title>VGKC-complex/LGI1-antibody encephalitis: Clinical manifestations and response to immunotherapy</title><author>Shin, Yong-Won ; Lee, Soon-Tae ; Shin, Jung-Won ; Moon, Jangsup ; Lim, Jung-Ah ; Byun, Jung-Ick ; Kim, Tae-Joon ; Lee, Keon-Joo ; Kim, Young-Su ; Park, Kyung-Il ; Jung, Keun-Hwa ; Lee, Sang Kun ; Chu, Kon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-8cf30efd9eb782a03a1a0f00dac84da9aa717da3f0217e948894e23edaf9b763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allergy and Immunology</topic><topic>Antibodies - blood</topic><topic>Autoantibodies - blood</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain Diseases - blood</topic><topic>Brain Diseases - diagnostic imaging</topic><topic>Brain Diseases - immunology</topic><topic>Brain Diseases - therapy</topic><topic>Electroencephalography</topic><topic>Encephalitis</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Hashimoto Disease - blood</topic><topic>Hashimoto Disease - diagnostic imaging</topic><topic>Hashimoto Disease - immunology</topic><topic>Hashimoto Disease - therapy</topic><topic>Humans</topic><topic>Immunoglobulins, Intravenous - therapeutic use</topic><topic>Immunotherapy</topic><topic>Immunotherapy - methods</topic><topic>LGI1</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Positron-Emission Tomography</topic><topic>Proteins - immunology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Yong-Won</creatorcontrib><creatorcontrib>Lee, Soon-Tae</creatorcontrib><creatorcontrib>Shin, Jung-Won</creatorcontrib><creatorcontrib>Moon, Jangsup</creatorcontrib><creatorcontrib>Lim, Jung-Ah</creatorcontrib><creatorcontrib>Byun, Jung-Ick</creatorcontrib><creatorcontrib>Kim, Tae-Joon</creatorcontrib><creatorcontrib>Lee, Keon-Joo</creatorcontrib><creatorcontrib>Kim, Young-Su</creatorcontrib><creatorcontrib>Park, Kyung-Il</creatorcontrib><creatorcontrib>Jung, Keun-Hwa</creatorcontrib><creatorcontrib>Lee, Sang Kun</creatorcontrib><creatorcontrib>Chu, Kon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Yong-Won</au><au>Lee, Soon-Tae</au><au>Shin, Jung-Won</au><au>Moon, Jangsup</au><au>Lim, Jung-Ah</au><au>Byun, Jung-Ick</au><au>Kim, Tae-Joon</au><au>Lee, Keon-Joo</au><au>Kim, Young-Su</au><au>Park, Kyung-Il</au><au>Jung, Keun-Hwa</au><au>Lee, Sang Kun</au><au>Chu, Kon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>VGKC-complex/LGI1-antibody encephalitis: Clinical manifestations and response to immunotherapy</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2013-12-15</date><risdate>2013</risdate><volume>265</volume><issue>1</issue><spage>75</spage><epage>81</epage><pages>75-81</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract Leucine-rich glioma inactivated 1 (LGI1) was recently identified as a target protein in autoimmune synaptic encephalitis, a rare condition associated with autoantibodies against structures in the neuronal synapse. Studies dealing with LGI1 are small in number and the various outcomes of different therapeutic regimens are not well studied. Here, we analyzed clinical characteristics of 14 patients with LGI1 antibodies, and outcomes according to therapeutic strategies. Most patients exhibited abnormal brain positron emission tomography and that patients treated with steroids alone were more likely to relapse and had less favorable outcomes than those treated with steroids and intravenous immunoglobulins.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24176648</pmid><doi>10.1016/j.jneuroim.2013.10.005</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Allergy and Immunology Antibodies - blood Autoantibodies - blood Brain - diagnostic imaging Brain - metabolism Brain - pathology Brain Diseases - blood Brain Diseases - diagnostic imaging Brain Diseases - immunology Brain Diseases - therapy Electroencephalography Encephalitis Female Fluorodeoxyglucose F18 Hashimoto Disease - blood Hashimoto Disease - diagnostic imaging Hashimoto Disease - immunology Hashimoto Disease - therapy Humans Immunoglobulins, Intravenous - therapeutic use Immunotherapy Immunotherapy - methods LGI1 Magnetic Resonance Imaging Male Middle Aged Neurology Positron-Emission Tomography Proteins - immunology Treatment Outcome |
| title | VGKC-complex/LGI1-antibody encephalitis: Clinical manifestations and response to immunotherapy |
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