Docking and pharmacophore-based alignment comparative molecular field analysis three-dimensional quantitative structure-activity relationship analysis of dihydrofolate reductase inhibitors by linear and nonlinear calibration methods

Comparative molecular field analysis (CoMFA) studies have been carried out on 2,4‐diamino‐5‐(2_‐arylpropargyl)pyrimidine derivatives such as dihydrofolate reductase (DHFR) anticancer inhibitors. Because of the interoperable results of CoMFA models, they are noteworthy tools in rational drug designs....

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