Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles
We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic sti...
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| Veröffentlicht in: | Journal of nanomaterials 2013-01, Vol.2013 (2013), p.1-6 |
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| container_issue | 2013 |
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| container_title | Journal of nanomaterials |
| container_volume | 2013 |
| creator | Wen, Weijia Hui, Yu Sanna Yi, Xin Wang, Limu Li, Shunbo Wang, Xiang Qin, Jianhua |
| description | We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system. |
| doi_str_mv | 10.1155/2013/864584 |
| format | Article |
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The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. 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Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.</description><subject>Active control</subject><subject>Devices</subject><subject>Mathematical models</subject><subject>Membranes</subject><subject>Microfluidics</subject><subject>Nanoparticles</subject><subject>Platforms</subject><subject>Stability</subject><issn>1687-4110</issn><issn>1687-4129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><recordid>eNqN0EtLxDAQwPEiCq6Pk3fJUZRq3tsel_UJq4LouUyTqRtJmzXpKn57KxXxpqfM4ccM-WfZAaOnjCl1xikTZ4WWqpAb2YTpYppLxsvNn5nR7WwnpRdKpSoVn2TtrTMxNH7trDPkHN-cQdKESOah62PwHmqPZL7E1hnw5AE9QkLy5oBcOvQ2n5l-DT1acottHaFDctOZEFchQu-6Z3IHXVhB7J3xmPayrQZ8wv3vdzd7urx4nF_ni_urm_lskYPU0z6vhYCyZppPjeUaQEkpeGGgLGupubCMAlqtJZ9KpI2mRnBBmW1QMVsIALGbHY17VzG8rjH1VeuSweE3HYZ1qpgcGilBpf4flWo4NdCTkQ7FUorYVKvoWogfFaPVV__qq3819h_08aiXrrPw7v7AhyPGgWADv7BgeoCfpZeOtg</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Wen, Weijia</creator><creator>Hui, Yu Sanna</creator><creator>Yi, Xin</creator><creator>Wang, Limu</creator><creator>Li, Shunbo</creator><creator>Wang, Xiang</creator><creator>Qin, Jianhua</creator><general>Hindawi Publishing Corporation</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20130101</creationdate><title>Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles</title><author>Wen, Weijia ; Hui, Yu Sanna ; Yi, Xin ; Wang, Limu ; Li, Shunbo ; Wang, Xiang ; Qin, Jianhua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a467t-b33a9b1627cd26aa544328ca99b4623d10aed664274e0f60c32301dfe51d83aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Active control</topic><topic>Devices</topic><topic>Mathematical models</topic><topic>Membranes</topic><topic>Microfluidics</topic><topic>Nanoparticles</topic><topic>Platforms</topic><topic>Stability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wen, Weijia</creatorcontrib><creatorcontrib>Hui, Yu Sanna</creatorcontrib><creatorcontrib>Yi, Xin</creatorcontrib><creatorcontrib>Wang, Limu</creatorcontrib><creatorcontrib>Li, Shunbo</creatorcontrib><creatorcontrib>Wang, Xiang</creatorcontrib><creatorcontrib>Qin, Jianhua</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of nanomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wen, Weijia</au><au>Hui, Yu Sanna</au><au>Yi, Xin</au><au>Wang, Limu</au><au>Li, Shunbo</au><au>Wang, Xiang</au><au>Qin, Jianhua</au><au>Vasilev, Krasimir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles</atitle><jtitle>Journal of nanomaterials</jtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>1687-4110</issn><eissn>1687-4129</eissn><abstract>We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><doi>10.1155/2013/864584</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Active control Devices Mathematical models Membranes Microfluidics Nanoparticles Platforms Stability |
| title | Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles |
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