Evaluation of the osteoconductive potential of bone substitutes embedded with schneiderian membrane- or maxillary bone marrow-derived osteoprogenitor cells
Aim Sinus augmentation procedures commonly employ osteoconductive scaffolding materials to stimulate and support bone formation. The aim of this study was to develop a simple screening methodology for the evaluation of the osteoconductive potential of various bone graft materials prior to clinical u...
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| Veröffentlicht in: | Clinical oral implants research 2013-12, Vol.24 (12), p.1288-1294 |
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| container_title | Clinical oral implants research |
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| creator | Srouji, Samer Ben-David, Dror Funari, Alessia Riminucci, Mara Bianco, Paolo |
| description | Aim
Sinus augmentation procedures commonly employ osteoconductive scaffolding materials to stimulate and support bone formation. The aim of this study was to develop a simple screening methodology for the evaluation of the osteoconductive potential of various bone graft materials prior to clinical use.
Materials and methods
Materials tested were Bio‐Oss, Bi‐Ostetic, OraGraft, and ProOsteon. These Simple and composite bone substitutes were embedded with osteoprogenitor cells derived from either the human maxillary sinus schneiderian membrane (hMSSM) or from maxillary tuberosity bone marrow and then monitored both in vitro and in vivo.
Results
Cell adherence and proliferation was most pronounced in OraGraft, followed by ProOsteon. In vivo bone formation, within the bone graft, was also observed, with most marked results in OraGraft and ProOsteon grafts.
Conclusions
The proposed osteoconductivity testing method proved simple, informative, and reliable for the purpose of screening candidate biomaterials for sinus lifting or sinus augmentation. |
| doi_str_mv | 10.1111/j.1600-0501.2012.02571.x |
| format | Article |
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Sinus augmentation procedures commonly employ osteoconductive scaffolding materials to stimulate and support bone formation. The aim of this study was to develop a simple screening methodology for the evaluation of the osteoconductive potential of various bone graft materials prior to clinical use.
Materials and methods
Materials tested were Bio‐Oss, Bi‐Ostetic, OraGraft, and ProOsteon. These Simple and composite bone substitutes were embedded with osteoprogenitor cells derived from either the human maxillary sinus schneiderian membrane (hMSSM) or from maxillary tuberosity bone marrow and then monitored both in vitro and in vivo.
Results
Cell adherence and proliferation was most pronounced in OraGraft, followed by ProOsteon. In vivo bone formation, within the bone graft, was also observed, with most marked results in OraGraft and ProOsteon grafts.
Conclusions
The proposed osteoconductivity testing method proved simple, informative, and reliable for the purpose of screening candidate biomaterials for sinus lifting or sinus augmentation.</description><identifier>ISSN: 0905-7161</identifier><identifier>EISSN: 1600-0501</identifier><identifier>DOI: 10.1111/j.1600-0501.2012.02571.x</identifier><identifier>PMID: 22882738</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Animals ; Biomaterials ; bone ; Bone Marrow Cells - drug effects ; Bone Substitutes - pharmacology ; Cell Adhesion - drug effects ; Cell Proliferation - drug effects ; Cells, Cultured ; Dentistry ; Humans ; Hydroxyapatites - pharmacology ; Mice ; Microscopy, Electron, Scanning ; Minerals - pharmacology ; Nasal Mucosa - surgery ; Osteogenesis - drug effects ; osteoprogenitors ; screening ; sinus augmentation ; Sinus Floor Augmentation - methods</subject><ispartof>Clinical oral implants research, 2013-12, Vol.24 (12), p.1288-1294</ispartof><rights>2012 John Wiley & Sons A/S</rights><rights>2012 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0501.2012.02571.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0501.2012.02571.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22882738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Srouji, Samer</creatorcontrib><creatorcontrib>Ben-David, Dror</creatorcontrib><creatorcontrib>Funari, Alessia</creatorcontrib><creatorcontrib>Riminucci, Mara</creatorcontrib><creatorcontrib>Bianco, Paolo</creatorcontrib><title>Evaluation of the osteoconductive potential of bone substitutes embedded with schneiderian membrane- or maxillary bone marrow-derived osteoprogenitor cells</title><title>Clinical oral implants research</title><addtitle>Clin. Oral Impl. Res</addtitle><description>Aim
Sinus augmentation procedures commonly employ osteoconductive scaffolding materials to stimulate and support bone formation. The aim of this study was to develop a simple screening methodology for the evaluation of the osteoconductive potential of various bone graft materials prior to clinical use.
Materials and methods
Materials tested were Bio‐Oss, Bi‐Ostetic, OraGraft, and ProOsteon. These Simple and composite bone substitutes were embedded with osteoprogenitor cells derived from either the human maxillary sinus schneiderian membrane (hMSSM) or from maxillary tuberosity bone marrow and then monitored both in vitro and in vivo.
Results
Cell adherence and proliferation was most pronounced in OraGraft, followed by ProOsteon. In vivo bone formation, within the bone graft, was also observed, with most marked results in OraGraft and ProOsteon grafts.
Conclusions
The proposed osteoconductivity testing method proved simple, informative, and reliable for the purpose of screening candidate biomaterials for sinus lifting or sinus augmentation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Biomaterials</subject><subject>bone</subject><subject>Bone Marrow Cells - drug effects</subject><subject>Bone Substitutes - pharmacology</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>Dentistry</subject><subject>Humans</subject><subject>Hydroxyapatites - pharmacology</subject><subject>Mice</subject><subject>Microscopy, Electron, Scanning</subject><subject>Minerals - pharmacology</subject><subject>Nasal Mucosa - surgery</subject><subject>Osteogenesis - drug effects</subject><subject>osteoprogenitors</subject><subject>screening</subject><subject>sinus augmentation</subject><subject>Sinus Floor Augmentation - methods</subject><issn>0905-7161</issn><issn>1600-0501</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EokPhFZCXbBL8E9vJggUadQrSCCTaiqVlJzeMhyQeYmd-noWXrdMps8YbWzrfuff6HoQwJTlN5-M2p5KQjAhCc0YoywkTiubHF2hxEV6iBamIyBSV9Aq9CWFLCJFVWb1GV4yVJVO8XKC_N3vTTSY6P2Df4rgB7EMEX_uhmero9oB3PsIQnelmwPoBcJhsiC5OEQKG3kLTQIMPLm5wqDcDuAZGZwbcJ200A2TYj7g3R9d1ZjydS_RmHP0hm8l9Mj_13I3-FwwuJrqGrgtv0avWdAHePd_X6GF1c7_8kq2_335dfl5njnNJM9YqRsuWNTVIyUGxWtiSFhwqqFTZWit4TblqoCwME1ZYU4CQdUNFZawBxq_Rh3PdNMCfCULUvQvzBGl2PwVNC1kIKiuu_gMtFCWlpDyh75_RyfbQ6N3o0qdP-t_uE_DpDBxcB6eLTomeM9ZbPUep5yj1nLF-ylgf9XL9Y34lf3b2u7S848Vvxt9aKq6E_vntVq_uuFqJldSEPwKbjq05</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Srouji, Samer</creator><creator>Ben-David, Dror</creator><creator>Funari, Alessia</creator><creator>Riminucci, Mara</creator><creator>Bianco, Paolo</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201312</creationdate><title>Evaluation of the osteoconductive potential of bone substitutes embedded with schneiderian membrane- or maxillary bone marrow-derived osteoprogenitor cells</title><author>Srouji, Samer ; Ben-David, Dror ; Funari, Alessia ; Riminucci, Mara ; Bianco, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3361-2f7218f2dce663e72c5b8143e9e978fbb53c137de84a25b5ba4e56cd159abae23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Biomaterials</topic><topic>bone</topic><topic>Bone Marrow Cells - drug effects</topic><topic>Bone Substitutes - pharmacology</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>Dentistry</topic><topic>Humans</topic><topic>Hydroxyapatites - pharmacology</topic><topic>Mice</topic><topic>Microscopy, Electron, Scanning</topic><topic>Minerals - pharmacology</topic><topic>Nasal Mucosa - surgery</topic><topic>Osteogenesis - drug effects</topic><topic>osteoprogenitors</topic><topic>screening</topic><topic>sinus augmentation</topic><topic>Sinus Floor Augmentation - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Srouji, Samer</creatorcontrib><creatorcontrib>Ben-David, Dror</creatorcontrib><creatorcontrib>Funari, Alessia</creatorcontrib><creatorcontrib>Riminucci, Mara</creatorcontrib><creatorcontrib>Bianco, Paolo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Clinical oral implants research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Srouji, Samer</au><au>Ben-David, Dror</au><au>Funari, Alessia</au><au>Riminucci, Mara</au><au>Bianco, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the osteoconductive potential of bone substitutes embedded with schneiderian membrane- or maxillary bone marrow-derived osteoprogenitor cells</atitle><jtitle>Clinical oral implants research</jtitle><addtitle>Clin. Oral Impl. Res</addtitle><date>2013-12</date><risdate>2013</risdate><volume>24</volume><issue>12</issue><spage>1288</spage><epage>1294</epage><pages>1288-1294</pages><issn>0905-7161</issn><eissn>1600-0501</eissn><abstract>Aim
Sinus augmentation procedures commonly employ osteoconductive scaffolding materials to stimulate and support bone formation. The aim of this study was to develop a simple screening methodology for the evaluation of the osteoconductive potential of various bone graft materials prior to clinical use.
Materials and methods
Materials tested were Bio‐Oss, Bi‐Ostetic, OraGraft, and ProOsteon. These Simple and composite bone substitutes were embedded with osteoprogenitor cells derived from either the human maxillary sinus schneiderian membrane (hMSSM) or from maxillary tuberosity bone marrow and then monitored both in vitro and in vivo.
Results
Cell adherence and proliferation was most pronounced in OraGraft, followed by ProOsteon. In vivo bone formation, within the bone graft, was also observed, with most marked results in OraGraft and ProOsteon grafts.
Conclusions
The proposed osteoconductivity testing method proved simple, informative, and reliable for the purpose of screening candidate biomaterials for sinus lifting or sinus augmentation.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>22882738</pmid><doi>10.1111/j.1600-0501.2012.02571.x</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Animals Biomaterials bone Bone Marrow Cells - drug effects Bone Substitutes - pharmacology Cell Adhesion - drug effects Cell Proliferation - drug effects Cells, Cultured Dentistry Humans Hydroxyapatites - pharmacology Mice Microscopy, Electron, Scanning Minerals - pharmacology Nasal Mucosa - surgery Osteogenesis - drug effects osteoprogenitors screening sinus augmentation Sinus Floor Augmentation - methods |
| title | Evaluation of the osteoconductive potential of bone substitutes embedded with schneiderian membrane- or maxillary bone marrow-derived osteoprogenitor cells |
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