Effects of sirtuin 1 activation on nicotine and lipopolysaccharide-induced cytotoxicity and inflammatory cytokine production in human gingival fibroblasts

Background and Objective Although sirtuin 1 (SIRT1) over‐expression and resveratrol exert anti‐inflammatory and proinflammatory effects, their effects and the mechanism of action on human gingival fibroblast (HGF)‐mediated inflammation are unknown. The aim of this study was to demonstrate the effect...

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Veröffentlicht in:	Journal of periodontal research 2013-08, Vol.48 (4), p.483-492
Hauptverfasser:	Park, G-J., Kim, Y-S., Kang, K-l., Bae, S-J., Baek, H-S., Auh, Q-S., Chun, Y-H., Park, B-H., Kim, E-C.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adenoviridae - genetics Adenovirus adenovirus SIRT1 anti-inflammatory Anti-Inflammatory Agents, Non-Steroidal - pharmacology Cell Line Cell Survival - drug effects Cyclooxygenase 2 - drug effects Dentistry Dinoprostone - metabolism Fibroblasts - drug effects Genetic Vectors - genetics Gingiva - cytology Gingiva - drug effects Humans Inflammation Mediators - metabolism Interleukins - metabolism lipopolysaccharides Lipopolysaccharides - pharmacology MAP Kinase Kinase 4 - antagonists & inhibitors Mitogen-Activated Protein Kinases - antagonists & inhibitors NF-kappa B - antagonists & inhibitors nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - antagonists & inhibitors Protein Kinase C - antagonists & inhibitors Reactive Oxygen Species - metabolism resvaratrol SIRT1 Sirtuin 1 - genetics Sirtuin 1 - pharmacology Stilbenes - pharmacology Tumor Necrosis Factor-alpha - drug effects Up-Regulation
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