Risk of Kidney Stones With Surgical Intervention in Living Kidney Donors
A kidney stone in a person with a solitary kidney requires urgent attention, which may result in surgical and/or hospital attention. We conducted a matched retrospective cohort study to determine if living kidney donors compared to healthy nondonors have a higher risk of: (i) kidney stones with surg...
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| Veröffentlicht in: | American journal of transplantation 2013-11, Vol.13 (11), p.2935-2944 |
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| creator | Thomas, S. M. Lam, N. N. Welk, B. K. Nguan, C. Huang, A. Nash, D. M. Prasad, G. V. R. Knoll, G. A. Koval, J. J. Lentine, K. L. Kim, S. J. Lok, C. E. Garg, A. X. |
| description | A kidney stone in a person with a solitary kidney requires urgent attention, which may result in surgical and/or hospital attention. We conducted a matched retrospective cohort study to determine if living kidney donors compared to healthy nondonors have a higher risk of: (i) kidney stones with surgical intervention, and (ii) hospital encounters for kidney stones. We reviewed all predonation charts for living kidney donations from 1992 to 2009 at five major transplant centers in Ontario, Canada, and linked this information to healthcare databases. We selected nondonors from the healthiest segment of the general population and matched 10 nondonors to every donor. Of the 2019 donors and 20 190 nondonors, none had evidence of kidney stones prior to cohort entry. Median follow‐up time was 8.4 years (maximum 19.7 years; loss to follow‐up |
| doi_str_mv | 10.1111/ajt.12446 |
| format | Article |
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This cohort study finds no significant difference in the rates of kidney stones with surgical intervention or hospital encounters for kidney stones when comparing 2019 living kidney donors to 20 190 healthy nondonors.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/ajt.12446</identifier><identifier>PMID: 24102981</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley</publisher><subject>Adult ; Biological and medical sciences ; Case-Control Studies ; Cohort study ; Confidence intervals ; Diet ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; health administrative data ; health outcomes ; Humans ; Kidney Calculi - diagnosis ; Kidney Calculi - etiology ; Kidney Calculi - surgery ; Kidney Failure, Chronic - epidemiology ; Kidney Failure, Chronic - surgery ; Kidney Function Tests ; Kidney stones ; Kidney Transplantation ; Living Donors ; living kidney donor ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Nephrectomy - adverse effects ; Nephrology. Urinary tract diseases ; Prognosis ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Retrospective Studies ; Risk Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue and Organ Harvesting ; transplantation ; Urinary lithiasis</subject><ispartof>American journal of transplantation, 2013-11, Vol.13 (11), p.2935-2944</ispartof><rights>Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4516-b2e88d855d73cbaeaff1849cf078aa8b4de5a26490414cc383373f8b4252a5803</citedby><cites>FETCH-LOGICAL-c4516-b2e88d855d73cbaeaff1849cf078aa8b4de5a26490414cc383373f8b4252a5803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajt.12446$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27962074$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24102981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomas, S. M.</creatorcontrib><creatorcontrib>Lam, N. N.</creatorcontrib><creatorcontrib>Welk, B. K.</creatorcontrib><creatorcontrib>Nguan, C.</creatorcontrib><creatorcontrib>Huang, A.</creatorcontrib><creatorcontrib>Nash, D. M.</creatorcontrib><creatorcontrib>Prasad, G. V. R.</creatorcontrib><creatorcontrib>Knoll, G. A.</creatorcontrib><creatorcontrib>Koval, J. J.</creatorcontrib><creatorcontrib>Lentine, K. L.</creatorcontrib><creatorcontrib>Kim, S. J.</creatorcontrib><creatorcontrib>Lok, C. E.</creatorcontrib><creatorcontrib>Garg, A. X.</creatorcontrib><creatorcontrib>Donor Nephrectomy Outcomes Research (DONOR) Network</creatorcontrib><title>Risk of Kidney Stones With Surgical Intervention in Living Kidney Donors</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>A kidney stone in a person with a solitary kidney requires urgent attention, which may result in surgical and/or hospital attention. We conducted a matched retrospective cohort study to determine if living kidney donors compared to healthy nondonors have a higher risk of: (i) kidney stones with surgical intervention, and (ii) hospital encounters for kidney stones. We reviewed all predonation charts for living kidney donations from 1992 to 2009 at five major transplant centers in Ontario, Canada, and linked this information to healthcare databases. We selected nondonors from the healthiest segment of the general population and matched 10 nondonors to every donor. Of the 2019 donors and 20 190 nondonors, none had evidence of kidney stones prior to cohort entry. Median follow‐up time was 8.4 years (maximum 19.7 years; loss to follow‐up <7%). There was no difference in the rate of kidney stones with surgical intervention in donors compared to nondonors (8.3 vs. 9.7 events/10 000 person‐years; rate ratio 0.85; 95% confidence interval [CI] 0.47–1.53). Similarly there was no difference in the rate of hospital encounters for kidney stones (12.1 vs. 16.1 events/10 000 person‐years; rate ratio 0.75; 95% CI 0.45–1.24). These interim results are reassuring for the safety of living kidney donation.
This cohort study finds no significant difference in the rates of kidney stones with surgical intervention or hospital encounters for kidney stones when comparing 2019 living kidney donors to 20 190 healthy nondonors.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cohort study</subject><subject>Confidence intervals</subject><subject>Diet</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glomerular Filtration Rate</subject><subject>health administrative data</subject><subject>health outcomes</subject><subject>Humans</subject><subject>Kidney Calculi - diagnosis</subject><subject>Kidney Calculi - etiology</subject><subject>Kidney Calculi - surgery</subject><subject>Kidney Failure, Chronic - epidemiology</subject><subject>Kidney Failure, Chronic - surgery</subject><subject>Kidney Function Tests</subject><subject>Kidney stones</subject><subject>Kidney Transplantation</subject><subject>Living Donors</subject><subject>living kidney donor</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Nephrectomy - adverse effects</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prognosis</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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K.</creator><creator>Nguan, C.</creator><creator>Huang, A.</creator><creator>Nash, D. M.</creator><creator>Prasad, G. V. R.</creator><creator>Knoll, G. A.</creator><creator>Koval, J. J.</creator><creator>Lentine, K. L.</creator><creator>Kim, S. J.</creator><creator>Lok, C. E.</creator><creator>Garg, A. X.</creator><general>Wiley</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>201311</creationdate><title>Risk of Kidney Stones With Surgical Intervention in Living Kidney Donors</title><author>Thomas, S. M. ; Lam, N. N. ; Welk, B. K. ; Nguan, C. ; Huang, A. ; Nash, D. M. ; Prasad, G. V. R. ; Knoll, G. A. ; Koval, J. 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Urinary tract diseases</topic><topic>Prognosis</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue and Organ Harvesting</topic><topic>transplantation</topic><topic>Urinary lithiasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomas, S. M.</creatorcontrib><creatorcontrib>Lam, N. N.</creatorcontrib><creatorcontrib>Welk, B. K.</creatorcontrib><creatorcontrib>Nguan, C.</creatorcontrib><creatorcontrib>Huang, A.</creatorcontrib><creatorcontrib>Nash, D. M.</creatorcontrib><creatorcontrib>Prasad, G. V. R.</creatorcontrib><creatorcontrib>Knoll, G. A.</creatorcontrib><creatorcontrib>Koval, J. J.</creatorcontrib><creatorcontrib>Lentine, K. L.</creatorcontrib><creatorcontrib>Kim, S. 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M.</au><au>Lam, N. N.</au><au>Welk, B. K.</au><au>Nguan, C.</au><au>Huang, A.</au><au>Nash, D. M.</au><au>Prasad, G. V. R.</au><au>Knoll, G. A.</au><au>Koval, J. J.</au><au>Lentine, K. L.</au><au>Kim, S. J.</au><au>Lok, C. E.</au><au>Garg, A. X.</au><aucorp>Donor Nephrectomy Outcomes Research (DONOR) Network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of Kidney Stones With Surgical Intervention in Living Kidney Donors</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2013-11</date><risdate>2013</risdate><volume>13</volume><issue>11</issue><spage>2935</spage><epage>2944</epage><pages>2935-2944</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>A kidney stone in a person with a solitary kidney requires urgent attention, which may result in surgical and/or hospital attention. We conducted a matched retrospective cohort study to determine if living kidney donors compared to healthy nondonors have a higher risk of: (i) kidney stones with surgical intervention, and (ii) hospital encounters for kidney stones. We reviewed all predonation charts for living kidney donations from 1992 to 2009 at five major transplant centers in Ontario, Canada, and linked this information to healthcare databases. We selected nondonors from the healthiest segment of the general population and matched 10 nondonors to every donor. Of the 2019 donors and 20 190 nondonors, none had evidence of kidney stones prior to cohort entry. Median follow‐up time was 8.4 years (maximum 19.7 years; loss to follow‐up <7%). There was no difference in the rate of kidney stones with surgical intervention in donors compared to nondonors (8.3 vs. 9.7 events/10 000 person‐years; rate ratio 0.85; 95% confidence interval [CI] 0.47–1.53). Similarly there was no difference in the rate of hospital encounters for kidney stones (12.1 vs. 16.1 events/10 000 person‐years; rate ratio 0.75; 95% CI 0.45–1.24). These interim results are reassuring for the safety of living kidney donation.
This cohort study finds no significant difference in the rates of kidney stones with surgical intervention or hospital encounters for kidney stones when comparing 2019 living kidney donors to 20 190 healthy nondonors.</abstract><cop>Hoboken, NJ</cop><pub>Wiley</pub><pmid>24102981</pmid><doi>10.1111/ajt.12446</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Case-Control Studies Cohort study Confidence intervals Diet Female Follow-Up Studies Glomerular Filtration Rate health administrative data health outcomes Humans Kidney Calculi - diagnosis Kidney Calculi - etiology Kidney Calculi - surgery Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - surgery Kidney Function Tests Kidney stones Kidney Transplantation Living Donors living kidney donor Male Medical sciences Middle Aged Miscellaneous Nephrectomy - adverse effects Nephrology. Urinary tract diseases Prognosis Public health. Hygiene Public health. Hygiene-occupational medicine Retrospective Studies Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue and Organ Harvesting transplantation Urinary lithiasis |
| title | Risk of Kidney Stones With Surgical Intervention in Living Kidney Donors |
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