Specific subcellular changes in oxidative stress in prefrontal cortex from patients with bipolar disorder

Previously, we found decreased mitochondrial complex I subunits levels and increased protein oxidation and nitration in postmortem prefrontal cortex (PFC) from patients with bipolar disorder (BD) and schizophrenia (SCZ). The objectives of this study were to replicate our findings in an independent s...

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Veröffentlicht in:	Journal of neurochemistry 2013-11, Vol.127 (4), p.552-561
Hauptverfasser:	Andreazza, Ana C., Wang, Jun‐Feng, Salmasi, Faraz, Shao, Li, Young, Lionel T.
Format:	Artikel
Sprache:	eng
Schlagworte:	antioxidant enzymes Bipolar disorder Bipolar Disorder - drug therapy Bipolar Disorder - metabolism Brain Case-Control Studies Electron Transport Complex I - metabolism Electron Transport Complex III - metabolism Female Glutathione Peroxidase - metabolism Humans Lipid Peroxidation Male Middle Aged Mitochondria Mitochondria - metabolism mitochondrial dysfunction Oxidation-Reduction Oxidative Stress Prefrontal Cortex - metabolism Schizophrenia - drug therapy Schizophrenia - metabolism Superoxide Dismutase - metabolism synapses Synaptosomes - metabolism Tyrosine - analogs & derivatives Tyrosine - metabolism
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