Forced Swimming Stress-Related Hypoalgesia:Nondependence on the Histaminergic Mechanisms
In experiments on mice, we examined the effects of 3-min-long forced swimming sessions on indices characterizing the state of the nociceptive system. Thirty minutes after the forced swimming episode, significantly shorter ( P < 0.05) latencies of motor reactions in the hot plate and tail flick te...
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| Veröffentlicht in: | Neurophysiology (New York) 2013-07, Vol.45 (4), p.340-343 |
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| creator | Ibironke, G. F. Rasak, K. S. |
| description | In experiments on mice, we examined the effects of 3-min-long forced swimming sessions on indices characterizing the state of the nociceptive system. Thirty minutes after the forced swimming episode, significantly shorter (
P
< 0.05) latencies of motor reactions in the hot plate and tail flick tests were observed. At the same time, times of licking the paw within the early and late phases of the formalin test, as well as numbers of writhings in the acetic acid test, became significantly (
P
< 0.05) smaller. Thus, forced swimming-induced stress results in the development of a hypoalgesia state with respect to thermoinduced pain and chemoinduced somatic (formalin test) and visceral (acetic acid test) pain. Blockers of histamine H1 (cimetidine, 10 mg/kg) and H2 (chlorpheniramine, 15 mg/kg) receptors did not influence significantly (
P
> 0.05) the intensity of forced swimming-induced hypoalgesia in the tail flick and acetic acid-induced (writhing) tests. Thus, the histaminergic system is not significantly involved in the mechanisms of forced swimming-induced hypoalgesia. |
| doi_str_mv | 10.1007/s11062-013-9378-1 |
| format | Article |
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P
< 0.05) latencies of motor reactions in the hot plate and tail flick tests were observed. At the same time, times of licking the paw within the early and late phases of the formalin test, as well as numbers of writhings in the acetic acid test, became significantly (
P
< 0.05) smaller. Thus, forced swimming-induced stress results in the development of a hypoalgesia state with respect to thermoinduced pain and chemoinduced somatic (formalin test) and visceral (acetic acid test) pain. Blockers of histamine H1 (cimetidine, 10 mg/kg) and H2 (chlorpheniramine, 15 mg/kg) receptors did not influence significantly (
P
> 0.05) the intensity of forced swimming-induced hypoalgesia in the tail flick and acetic acid-induced (writhing) tests. Thus, the histaminergic system is not significantly involved in the mechanisms of forced swimming-induced hypoalgesia.</description><identifier>ISSN: 0090-2977</identifier><identifier>EISSN: 1573-9007</identifier><identifier>DOI: 10.1007/s11062-013-9378-1</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Acetic acid ; Animal behavior ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cimetidine ; Formaldehyde ; Histamine ; Neurobiology ; Neurosciences ; Organic acids ; Rodents ; Swimming</subject><ispartof>Neurophysiology (New York), 2013-07, Vol.45 (4), p.340-343</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-3d6e81a9bcc414e62006be962a53b6e2d47b53a1d569efdb609349dcc9182feb3</citedby><cites>FETCH-LOGICAL-c493t-3d6e81a9bcc414e62006be962a53b6e2d47b53a1d569efdb609349dcc9182feb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11062-013-9378-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11062-013-9378-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Ibironke, G. F.</creatorcontrib><creatorcontrib>Rasak, K. S.</creatorcontrib><title>Forced Swimming Stress-Related Hypoalgesia:Nondependence on the Histaminergic Mechanisms</title><title>Neurophysiology (New York)</title><addtitle>Neurophysiology</addtitle><description>In experiments on mice, we examined the effects of 3-min-long forced swimming sessions on indices characterizing the state of the nociceptive system. Thirty minutes after the forced swimming episode, significantly shorter (
P
< 0.05) latencies of motor reactions in the hot plate and tail flick tests were observed. At the same time, times of licking the paw within the early and late phases of the formalin test, as well as numbers of writhings in the acetic acid test, became significantly (
P
< 0.05) smaller. Thus, forced swimming-induced stress results in the development of a hypoalgesia state with respect to thermoinduced pain and chemoinduced somatic (formalin test) and visceral (acetic acid test) pain. Blockers of histamine H1 (cimetidine, 10 mg/kg) and H2 (chlorpheniramine, 15 mg/kg) receptors did not influence significantly (
P
> 0.05) the intensity of forced swimming-induced hypoalgesia in the tail flick and acetic acid-induced (writhing) tests. 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P
< 0.05) latencies of motor reactions in the hot plate and tail flick tests were observed. At the same time, times of licking the paw within the early and late phases of the formalin test, as well as numbers of writhings in the acetic acid test, became significantly (
P
< 0.05) smaller. Thus, forced swimming-induced stress results in the development of a hypoalgesia state with respect to thermoinduced pain and chemoinduced somatic (formalin test) and visceral (acetic acid test) pain. Blockers of histamine H1 (cimetidine, 10 mg/kg) and H2 (chlorpheniramine, 15 mg/kg) receptors did not influence significantly (
P
> 0.05) the intensity of forced swimming-induced hypoalgesia in the tail flick and acetic acid-induced (writhing) tests. Thus, the histaminergic system is not significantly involved in the mechanisms of forced swimming-induced hypoalgesia.</abstract><cop>Boston</cop><pub>Springer US</pub><doi>10.1007/s11062-013-9378-1</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetic acid Animal behavior Biomedical and Life Sciences Biomedicine Brain Cimetidine Formaldehyde Histamine Neurobiology Neurosciences Organic acids Rodents Swimming |
| title | Forced Swimming Stress-Related Hypoalgesia:Nondependence on the Histaminergic Mechanisms |
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