Functional Activity of Neutrophils in Diabetes Mellitus and Coronary Heart Disease: Role of Myeloperoxidase in the Development of Oxidative Stress
We performed a comparative analysis of functional activity of neutrophils in patients with type 2 diabetes mellitus with and without symptoms of CHD. Enhanced H 2 O 2 production by neutrophils in response to N-formyl-Met-Leu-Phe (fMLP) was found in patients with type 2 diabetes mellitus. In patients...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2012-11, Vol.154 (1), p.23-26 |
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| creator | Gorudko, I. V. Kostevich, V. A. Sokolov, A. V. Shamova, E. V. Buko, I. V. Konstantinova, E. E. Vasiliev, V. B. Cherenkevich, S. N. Panasenko, O. M. |
| description | We performed a comparative analysis of functional activity of neutrophils in patients with type 2 diabetes mellitus with and without symptoms of CHD. Enhanced H
2
O
2
production by neutrophils in response to N-formyl-Met-Leu-Phe (fMLP) was found in patients with type 2 diabetes mellitus. In patients with type 2 diabetes mellitus associated with CHD, fML-Pinduced release of myeloperoxidase from azurophilic granules of neutrophils was reduced and plasma myeloperoxidase level was elevated. Increased peroxidase activity of myeloperoxidase, reduced plasma catalase activity, and increased levels of TBA-reactive lipid peroxidation products and oxidized glutathione were detected in patients of both groups. Since myeloperoxidase is an important neutrophilic mediator of oxidative stress, its increased activity in the blood can be an additional marker of oxidative stress and cardiovascular risk in patients with diabetes mellitus. |
| doi_str_mv | 10.1007/s10517-012-1865-7 |
| format | Article |
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2
O
2
production by neutrophils in response to N-formyl-Met-Leu-Phe (fMLP) was found in patients with type 2 diabetes mellitus. In patients with type 2 diabetes mellitus associated with CHD, fML-Pinduced release of myeloperoxidase from azurophilic granules of neutrophils was reduced and plasma myeloperoxidase level was elevated. Increased peroxidase activity of myeloperoxidase, reduced plasma catalase activity, and increased levels of TBA-reactive lipid peroxidation products and oxidized glutathione were detected in patients of both groups. Since myeloperoxidase is an important neutrophilic mediator of oxidative stress, its increased activity in the blood can be an additional marker of oxidative stress and cardiovascular risk in patients with diabetes mellitus.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-012-1865-7</identifier><identifier>PMID: 23330081</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Blood ; Cardiac patients ; Catalase - metabolism ; Cell Biology ; Coronary Disease - metabolism ; Coronary heart disease ; Diabetes Mellitus, Type 2 - metabolism ; Diabetics ; Enzyme Activation ; General Pathology and Pathophysiology ; Glutathione - metabolism ; Humans ; Hydrogen Peroxide - metabolism ; Internal Medicine ; Laboratory Medicine ; Lipid peroxidation ; Middle Aged ; N-Formylmethionine Leucyl-Phenylalanine - analogs & derivatives ; N-Formylmethionine Leucyl-Phenylalanine - pharmacology ; Neutrophils - metabolism ; Oxidative Stress ; Pathology ; Peroxidase - metabolism ; Reactive Oxygen Species - metabolism ; Type 2 diabetes</subject><ispartof>Bulletin of experimental biology and medicine, 2012-11, Vol.154 (1), p.23-26</ispartof><rights>Springer Science+Business Media New York 2012</rights><rights>COPYRIGHT 2012 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-c024852dc05bf3a4e2fd7fe50439b4cfad55c61c88db83077e5c84d6384d62783</citedby><cites>FETCH-LOGICAL-c503t-c024852dc05bf3a4e2fd7fe50439b4cfad55c61c88db83077e5c84d6384d62783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-012-1865-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-012-1865-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23330081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gorudko, I. V.</creatorcontrib><creatorcontrib>Kostevich, V. A.</creatorcontrib><creatorcontrib>Sokolov, A. V.</creatorcontrib><creatorcontrib>Shamova, E. V.</creatorcontrib><creatorcontrib>Buko, I. V.</creatorcontrib><creatorcontrib>Konstantinova, E. E.</creatorcontrib><creatorcontrib>Vasiliev, V. B.</creatorcontrib><creatorcontrib>Cherenkevich, S. N.</creatorcontrib><creatorcontrib>Panasenko, O. M.</creatorcontrib><title>Functional Activity of Neutrophils in Diabetes Mellitus and Coronary Heart Disease: Role of Myeloperoxidase in the Development of Oxidative Stress</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We performed a comparative analysis of functional activity of neutrophils in patients with type 2 diabetes mellitus with and without symptoms of CHD. Enhanced H
2
O
2
production by neutrophils in response to N-formyl-Met-Leu-Phe (fMLP) was found in patients with type 2 diabetes mellitus. In patients with type 2 diabetes mellitus associated with CHD, fML-Pinduced release of myeloperoxidase from azurophilic granules of neutrophils was reduced and plasma myeloperoxidase level was elevated. Increased peroxidase activity of myeloperoxidase, reduced plasma catalase activity, and increased levels of TBA-reactive lipid peroxidation products and oxidized glutathione were detected in patients of both groups. Since myeloperoxidase is an important neutrophilic mediator of oxidative stress, its increased activity in the blood can be an additional marker of oxidative stress and cardiovascular risk in patients with diabetes mellitus.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Cardiac patients</subject><subject>Catalase - metabolism</subject><subject>Cell Biology</subject><subject>Coronary Disease - metabolism</subject><subject>Coronary heart disease</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetics</subject><subject>Enzyme Activation</subject><subject>General Pathology and Pathophysiology</subject><subject>Glutathione - metabolism</subject><subject>Humans</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Lipid peroxidation</subject><subject>Middle Aged</subject><subject>N-Formylmethionine Leucyl-Phenylalanine - analogs & derivatives</subject><subject>N-Formylmethionine Leucyl-Phenylalanine - pharmacology</subject><subject>Neutrophils - metabolism</subject><subject>Oxidative Stress</subject><subject>Pathology</subject><subject>Peroxidase - metabolism</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Type 2 diabetes</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkl1rFDEUhoModq3-AG8kIIg3U_MxmWS9W7bWCq0FP65DJnOmmzIz2SaZ4v4Nf7EJW7UVBQlMMuc87zucyYvQc0qOKCHyTaREUFkRyiqqGlHJB2hBheSVYow-RAuSoapWSh2gJzFelVfS0MfogHHOCVF0gb6fzJNNzk9mwKt8uHFph32PP8Kcgt9u3BCxm_CxMy0kiPgchsGlOWIzdXjtQxaGHT4FE1KGIpgIb_EnP0AxOd_B4LcQ_DfX5UYxShvAx3BT6iNMqVAXpZu_DPhzChDjU_SoN0OEZ7f7Ifp68u7L-rQ6u3j_Yb06q6wgPFWWsFoJ1lki2p6bGljfyR4EqfmyrW1vOiFsQ61SXas4kRKEVXXX8PJgUvFD9Hrvuw3-eoaY9OiizfOZCfwcNa2bWpClYv-BMskbQRkRGX35B3rl55B_bzGkvCZKUfWbujQDaDf1PgVji6lecUVoLaRcZuroL1ReHYzO-gl6l-v3BK_uCDZghrSJfpjLBcf7IN2DNvgYA_R6G9yYr1JToku29D5bOmdLl2xpmTUvbieb2xG6X4qfYcoA2wMxt6ZLCHdG_6frD_5w17g</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Gorudko, I. 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V.</au><au>Kostevich, V. A.</au><au>Sokolov, A. V.</au><au>Shamova, E. V.</au><au>Buko, I. V.</au><au>Konstantinova, E. E.</au><au>Vasiliev, V. B.</au><au>Cherenkevich, S. N.</au><au>Panasenko, O. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional Activity of Neutrophils in Diabetes Mellitus and Coronary Heart Disease: Role of Myeloperoxidase in the Development of Oxidative Stress</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>154</volume><issue>1</issue><spage>23</spage><epage>26</epage><pages>23-26</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>We performed a comparative analysis of functional activity of neutrophils in patients with type 2 diabetes mellitus with and without symptoms of CHD. Enhanced H
2
O
2
production by neutrophils in response to N-formyl-Met-Leu-Phe (fMLP) was found in patients with type 2 diabetes mellitus. In patients with type 2 diabetes mellitus associated with CHD, fML-Pinduced release of myeloperoxidase from azurophilic granules of neutrophils was reduced and plasma myeloperoxidase level was elevated. Increased peroxidase activity of myeloperoxidase, reduced plasma catalase activity, and increased levels of TBA-reactive lipid peroxidation products and oxidized glutathione were detected in patients of both groups. Since myeloperoxidase is an important neutrophilic mediator of oxidative stress, its increased activity in the blood can be an additional marker of oxidative stress and cardiovascular risk in patients with diabetes mellitus.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23330081</pmid><doi>10.1007/s10517-012-1865-7</doi><tpages>4</tpages></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Blood Cardiac patients Catalase - metabolism Cell Biology Coronary Disease - metabolism Coronary heart disease Diabetes Mellitus, Type 2 - metabolism Diabetics Enzyme Activation General Pathology and Pathophysiology Glutathione - metabolism Humans Hydrogen Peroxide - metabolism Internal Medicine Laboratory Medicine Lipid peroxidation Middle Aged N-Formylmethionine Leucyl-Phenylalanine - analogs & derivatives N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - metabolism Oxidative Stress Pathology Peroxidase - metabolism Reactive Oxygen Species - metabolism Type 2 diabetes |
| title | Functional Activity of Neutrophils in Diabetes Mellitus and Coronary Heart Disease: Role of Myeloperoxidase in the Development of Oxidative Stress |
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