Toll-like receptor 4/nuclear factor-κB signaling pathway is involved in ACTG-toxin H-mediated anti-inflammatory effect

ACTG-toxin H (AH) originates from Alternaria sp. In this study, we explored the molecular mechanism underlying the anti-inflammatory properties of AH. Treatment with AH inhibited lipopolysaccharide (LPS)-induced interleukin-6, IL-1β, inducible nitric oxide synthase, and cyclooxygenase-2 expression a...

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Veröffentlicht in:	Molecular and cellular biochemistry 2013-02, Vol.374 (1-2), p.29-36
Hauptverfasser:	Yang, Xinying, Zhang, Guojian, Tang, Xuelian, Jiao, Jieying, Kim, Sung Yeon, Lee, Joo Young, Zhu, Tianjiao, Li, Dehai, Yun, Yong Gab, Gu, Qianqun, Park, Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Alternaria Alternaria - metabolism Animals Anti-Inflammatory Agents - pharmacology Biochemistry Biomedical and Life Sciences Cardiology Cell Line Cell Survival COX-2 inhibitors Cyclooxygenase 2 - metabolism DNA DNA-Binding Proteins - metabolism Enzyme Activation - drug effects Enzymes Genetic research HEK293 Cells Humans Infection Inflammation - immunology Interleukin-1beta - metabolism Interleukin-6 - metabolism Life Sciences Lipopolysaccharides Macrophages - metabolism Medical Biochemistry Mice Mitogens Mycotoxins - pharmacology NF-kappa B - metabolism Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - metabolism Oncology p38 Mitogen-Activated Protein Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Signal Transduction T cells Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism
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