Plasma and urinary levels of cytokines in patients with idiopathic hypercalciuria
Background Recent studies suggest that cytokines modulate bone turnover. Idiopathic hypercalciuria (IH) seems to be associated with bone mineral loss. Therefore, the aim of this study was to assess cytokines involved in bone turnover in patients with IH. Methods Plasma and spot-urine levels of inter...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2012-06, Vol.27 (6), p.941-948 |
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| container_title | Pediatric nephrology (Berlin, West) |
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| creator | Santos, Augusto C. S. Lima, Eleonora M. Penido, Maria Goretti M. G. Silveira, Katia D. Teixeira, Mauro M. Oliveira, Eduardo A. Simões e Silva, Ana Cristina |
| description | Background
Recent studies suggest that cytokines modulate bone turnover. Idiopathic hypercalciuria (IH) seems to be associated with bone mineral loss. Therefore, the aim of this study was to assess cytokines involved in bone turnover in patients with IH.
Methods
Plasma and spot-urine levels of interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor alpha (TNF-α), transforming growth factor β1 (TGF-β1), and monocyte chemoattractant protein (MCP-1) were measured in 70 children and adolescents with IH and in 37 healthy controls. Patients with IH were subdivided according to their calciuria at the time of sample collection: ≥4 mg/kg/day (persistent IH,
n
=27) and below 4 mg/kg/day (controlled IH,
n
=43). Cytokines were determined by enzyme-linked immunoassay.
Results
Plasma and urinary concentrations of IL-1β, IL-6, IL-8, and TNF-α were undetectable in all groups. No differences were found between controlled and persistent hypercalciuria for plasma and urinary levels of MCP-1 and TGF-β1. On the other hand, MCP-1 levels were significantly higher in both subgroups of IH in comparison to healthy controls. Furthermore, urinary MCP-1 levels of IH patients correlated positively with bone mineral content (
p
=0.013).
Conclusion
Although cytokine measurements did not allow the differentiation between persistent and controlled IH, our findings suggest that MCP-1 might play a role in patients with IH. |
| doi_str_mv | 10.1007/s00467-011-2094-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1464504428</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A332022451</galeid><sourcerecordid>A332022451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-9a83ef7fe2401d603e44ed612189152475e0d554688f9be869abd1283a477ad83</originalsourceid><addsrcrecordid>eNqNkl1rFDEUhoModq3-AG8kIIg3U0--ZiaXpfgFBRUUeheyM2d2UjPJmswo--_NslVbWcHkInDyvG84Jy8hTxmcMYDmVQaQdVMBYxUHLSt5j6yYFLxiur26T1agBatAsqsT8ijnawBoVVs_JCe8LMEkW5FPH73Nk6U29HRJLti0ox6_o880DrTbzfGrC5ipC3RrZ4dhzvSHm0fqehdLZXQdHXdbTJ31nSsO9jF5MFif8cnNeUq-vHn9-eJddfnh7fuL88uqU5LNlbatwKEZkEtgfQ0CpcS-Zpy1mikuG4XQKyXrth30Gtta23XPeCusbBrbt-KUvDz4blP8tmCezeRyh97bgHHJhslaKpCS_wcKDLhoysMFff4Xeh2XFEojhdJKaa0E_KE21qNxYYhzst3e1JwLwYFzqfZe1RFqgwGT9THg4Er5Dn92hC-7x8l1RwUvbglGtH4ec_TL7GLId0F2ALsUc044mG1yU_nr0pTZR8kcomRKlMw-SkYWzbObSSzrCfvfil_ZKQA_ALlchQ2m26P6l-tP-STPBQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1095599530</pqid></control><display><type>article</type><title>Plasma and urinary levels of cytokines in patients with idiopathic hypercalciuria</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Santos, Augusto C. S. ; Lima, Eleonora M. ; Penido, Maria Goretti M. G. ; Silveira, Katia D. ; Teixeira, Mauro M. ; Oliveira, Eduardo A. ; Simões e Silva, Ana Cristina</creator><creatorcontrib>Santos, Augusto C. S. ; Lima, Eleonora M. ; Penido, Maria Goretti M. G. ; Silveira, Katia D. ; Teixeira, Mauro M. ; Oliveira, Eduardo A. ; Simões e Silva, Ana Cristina</creatorcontrib><description>Background
Recent studies suggest that cytokines modulate bone turnover. Idiopathic hypercalciuria (IH) seems to be associated with bone mineral loss. Therefore, the aim of this study was to assess cytokines involved in bone turnover in patients with IH.
Methods
Plasma and spot-urine levels of interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor alpha (TNF-α), transforming growth factor β1 (TGF-β1), and monocyte chemoattractant protein (MCP-1) were measured in 70 children and adolescents with IH and in 37 healthy controls. Patients with IH were subdivided according to their calciuria at the time of sample collection: ≥4 mg/kg/day (persistent IH,
n
=27) and below 4 mg/kg/day (controlled IH,
n
=43). Cytokines were determined by enzyme-linked immunoassay.
Results
Plasma and urinary concentrations of IL-1β, IL-6, IL-8, and TNF-α were undetectable in all groups. No differences were found between controlled and persistent hypercalciuria for plasma and urinary levels of MCP-1 and TGF-β1. On the other hand, MCP-1 levels were significantly higher in both subgroups of IH in comparison to healthy controls. Furthermore, urinary MCP-1 levels of IH patients correlated positively with bone mineral content (
p
=0.013).
Conclusion
Although cytokine measurements did not allow the differentiation between persistent and controlled IH, our findings suggest that MCP-1 might play a role in patients with IH.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-011-2094-4</identifier><identifier>PMID: 22223141</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Absorptiometry, Photon ; Adolescence ; Adolescent ; Age Factors ; Biomarkers ; Biomarkers - blood ; Biomarkers - urine ; Blood pressure ; Body mass index ; Bone Density ; Bone morphogenetic proteins ; Bone Remodeling ; Brazil ; Calcium - urine ; Case-Control Studies ; Chemokine CCL2 - blood ; Chemokine CCL2 - urine ; Child ; Creatinine ; Cross-Sectional Studies ; Cytokines ; Cytokines - blood ; Cytokines - urine ; Enzyme-Linked Immunosorbent Assay ; Female ; Growth factors ; Humans ; Hypercalciuria - blood ; Hypercalciuria - diagnostic imaging ; Hypercalciuria - immunology ; Hypercalciuria - urine ; Interleukin-1beta - blood ; Interleukin-1beta - urine ; Interleukin-6 - blood ; Interleukin-6 - urine ; Interleukin-8 - blood ; Interleukin-8 - urine ; Kidney stones ; Lumbar Vertebrae - diagnostic imaging ; Male ; Medicine ; Medicine & Public Health ; Nephrology ; Pediatrics ; Plasma ; Teenagers ; Transforming Growth Factor beta1 - blood ; Transforming Growth Factor beta1 - urine ; Transforming growth factors ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - blood ; Tumor Necrosis Factor-alpha - urine ; Tumor necrosis factor-TNF ; Uric acid ; Urine ; Urology ; Young Adult</subject><ispartof>Pediatric nephrology (Berlin, West), 2012-06, Vol.27 (6), p.941-948</ispartof><rights>IPNA 2012</rights><rights>COPYRIGHT 2012 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-9a83ef7fe2401d603e44ed612189152475e0d554688f9be869abd1283a477ad83</citedby><cites>FETCH-LOGICAL-c541t-9a83ef7fe2401d603e44ed612189152475e0d554688f9be869abd1283a477ad83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00467-011-2094-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00467-011-2094-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22223141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santos, Augusto C. S.</creatorcontrib><creatorcontrib>Lima, Eleonora M.</creatorcontrib><creatorcontrib>Penido, Maria Goretti M. G.</creatorcontrib><creatorcontrib>Silveira, Katia D.</creatorcontrib><creatorcontrib>Teixeira, Mauro M.</creatorcontrib><creatorcontrib>Oliveira, Eduardo A.</creatorcontrib><creatorcontrib>Simões e Silva, Ana Cristina</creatorcontrib><title>Plasma and urinary levels of cytokines in patients with idiopathic hypercalciuria</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><addtitle>Pediatr Nephrol</addtitle><description>Background
Recent studies suggest that cytokines modulate bone turnover. Idiopathic hypercalciuria (IH) seems to be associated with bone mineral loss. Therefore, the aim of this study was to assess cytokines involved in bone turnover in patients with IH.
Methods
Plasma and spot-urine levels of interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor alpha (TNF-α), transforming growth factor β1 (TGF-β1), and monocyte chemoattractant protein (MCP-1) were measured in 70 children and adolescents with IH and in 37 healthy controls. Patients with IH were subdivided according to their calciuria at the time of sample collection: ≥4 mg/kg/day (persistent IH,
n
=27) and below 4 mg/kg/day (controlled IH,
n
=43). Cytokines were determined by enzyme-linked immunoassay.
Results
Plasma and urinary concentrations of IL-1β, IL-6, IL-8, and TNF-α were undetectable in all groups. No differences were found between controlled and persistent hypercalciuria for plasma and urinary levels of MCP-1 and TGF-β1. On the other hand, MCP-1 levels were significantly higher in both subgroups of IH in comparison to healthy controls. Furthermore, urinary MCP-1 levels of IH patients correlated positively with bone mineral content (
p
=0.013).
Conclusion
Although cytokine measurements did not allow the differentiation between persistent and controlled IH, our findings suggest that MCP-1 might play a role in patients with IH.</description><subject>Absorptiometry, Photon</subject><subject>Adolescence</subject><subject>Adolescent</subject><subject>Age Factors</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Bone Density</subject><subject>Bone morphogenetic proteins</subject><subject>Bone Remodeling</subject><subject>Brazil</subject><subject>Calcium - urine</subject><subject>Case-Control Studies</subject><subject>Chemokine CCL2 - blood</subject><subject>Chemokine CCL2 - urine</subject><subject>Child</subject><subject>Creatinine</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Cytokines - urine</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Hypercalciuria - blood</subject><subject>Hypercalciuria - diagnostic imaging</subject><subject>Hypercalciuria - immunology</subject><subject>Hypercalciuria - urine</subject><subject>Interleukin-1beta - blood</subject><subject>Interleukin-1beta - urine</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - urine</subject><subject>Interleukin-8 - blood</subject><subject>Interleukin-8 - urine</subject><subject>Kidney stones</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Pediatrics</subject><subject>Plasma</subject><subject>Teenagers</subject><subject>Transforming Growth Factor beta1 - blood</subject><subject>Transforming Growth Factor beta1 - urine</subject><subject>Transforming growth factors</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor Necrosis Factor-alpha - urine</subject><subject>Tumor necrosis factor-TNF</subject><subject>Uric acid</subject><subject>Urine</subject><subject>Urology</subject><subject>Young Adult</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkl1rFDEUhoModq3-AG8kIIg3U0--ZiaXpfgFBRUUeheyM2d2UjPJmswo--_NslVbWcHkInDyvG84Jy8hTxmcMYDmVQaQdVMBYxUHLSt5j6yYFLxiur26T1agBatAsqsT8ijnawBoVVs_JCe8LMEkW5FPH73Nk6U29HRJLti0ox6_o880DrTbzfGrC5ipC3RrZ4dhzvSHm0fqehdLZXQdHXdbTJ31nSsO9jF5MFif8cnNeUq-vHn9-eJddfnh7fuL88uqU5LNlbatwKEZkEtgfQ0CpcS-Zpy1mikuG4XQKyXrth30Gtta23XPeCusbBrbt-KUvDz4blP8tmCezeRyh97bgHHJhslaKpCS_wcKDLhoysMFff4Xeh2XFEojhdJKaa0E_KE21qNxYYhzst3e1JwLwYFzqfZe1RFqgwGT9THg4Er5Dn92hC-7x8l1RwUvbglGtH4ec_TL7GLId0F2ALsUc044mG1yU_nr0pTZR8kcomRKlMw-SkYWzbObSSzrCfvfil_ZKQA_ALlchQ2m26P6l-tP-STPBQ</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Santos, Augusto C. S.</creator><creator>Lima, Eleonora M.</creator><creator>Penido, Maria Goretti M. G.</creator><creator>Silveira, Katia D.</creator><creator>Teixeira, Mauro M.</creator><creator>Oliveira, Eduardo A.</creator><creator>Simões e Silva, Ana Cristina</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20120601</creationdate><title>Plasma and urinary levels of cytokines in patients with idiopathic hypercalciuria</title><author>Santos, Augusto C. S. ; Lima, Eleonora M. ; Penido, Maria Goretti M. G. ; Silveira, Katia D. ; Teixeira, Mauro M. ; Oliveira, Eduardo A. ; Simões e Silva, Ana Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-9a83ef7fe2401d603e44ed612189152475e0d554688f9be869abd1283a477ad83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Absorptiometry, Photon</topic><topic>Adolescence</topic><topic>Adolescent</topic><topic>Age Factors</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Bone Density</topic><topic>Bone morphogenetic proteins</topic><topic>Bone Remodeling</topic><topic>Brazil</topic><topic>Calcium - urine</topic><topic>Case-Control Studies</topic><topic>Chemokine CCL2 - blood</topic><topic>Chemokine CCL2 - urine</topic><topic>Child</topic><topic>Creatinine</topic><topic>Cross-Sectional Studies</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Cytokines - urine</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Hypercalciuria - blood</topic><topic>Hypercalciuria - diagnostic imaging</topic><topic>Hypercalciuria - immunology</topic><topic>Hypercalciuria - urine</topic><topic>Interleukin-1beta - blood</topic><topic>Interleukin-1beta - urine</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - urine</topic><topic>Interleukin-8 - blood</topic><topic>Interleukin-8 - urine</topic><topic>Kidney stones</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Pediatrics</topic><topic>Plasma</topic><topic>Teenagers</topic><topic>Transforming Growth Factor beta1 - blood</topic><topic>Transforming Growth Factor beta1 - urine</topic><topic>Transforming growth factors</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor Necrosis Factor-alpha - urine</topic><topic>Tumor necrosis factor-TNF</topic><topic>Uric acid</topic><topic>Urine</topic><topic>Urology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santos, Augusto C. S.</creatorcontrib><creatorcontrib>Lima, Eleonora M.</creatorcontrib><creatorcontrib>Penido, Maria Goretti M. G.</creatorcontrib><creatorcontrib>Silveira, Katia D.</creatorcontrib><creatorcontrib>Teixeira, Mauro M.</creatorcontrib><creatorcontrib>Oliveira, Eduardo A.</creatorcontrib><creatorcontrib>Simões e Silva, Ana Cristina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santos, Augusto C. S.</au><au>Lima, Eleonora M.</au><au>Penido, Maria Goretti M. G.</au><au>Silveira, Katia D.</au><au>Teixeira, Mauro M.</au><au>Oliveira, Eduardo A.</au><au>Simões e Silva, Ana Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma and urinary levels of cytokines in patients with idiopathic hypercalciuria</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><stitle>Pediatr Nephrol</stitle><addtitle>Pediatr Nephrol</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>27</volume><issue>6</issue><spage>941</spage><epage>948</epage><pages>941-948</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><abstract>Background
Recent studies suggest that cytokines modulate bone turnover. Idiopathic hypercalciuria (IH) seems to be associated with bone mineral loss. Therefore, the aim of this study was to assess cytokines involved in bone turnover in patients with IH.
Methods
Plasma and spot-urine levels of interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor alpha (TNF-α), transforming growth factor β1 (TGF-β1), and monocyte chemoattractant protein (MCP-1) were measured in 70 children and adolescents with IH and in 37 healthy controls. Patients with IH were subdivided according to their calciuria at the time of sample collection: ≥4 mg/kg/day (persistent IH,
n
=27) and below 4 mg/kg/day (controlled IH,
n
=43). Cytokines were determined by enzyme-linked immunoassay.
Results
Plasma and urinary concentrations of IL-1β, IL-6, IL-8, and TNF-α were undetectable in all groups. No differences were found between controlled and persistent hypercalciuria for plasma and urinary levels of MCP-1 and TGF-β1. On the other hand, MCP-1 levels were significantly higher in both subgroups of IH in comparison to healthy controls. Furthermore, urinary MCP-1 levels of IH patients correlated positively with bone mineral content (
p
=0.013).
Conclusion
Although cytokine measurements did not allow the differentiation between persistent and controlled IH, our findings suggest that MCP-1 might play a role in patients with IH.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22223141</pmid><doi>10.1007/s00467-011-2094-4</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Pediatric nephrology (Berlin, West), 2012-06, Vol.27 (6), p.941-948 |
| issn | 0931-041X 1432-198X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Absorptiometry, Photon Adolescence Adolescent Age Factors Biomarkers Biomarkers - blood Biomarkers - urine Blood pressure Body mass index Bone Density Bone morphogenetic proteins Bone Remodeling Brazil Calcium - urine Case-Control Studies Chemokine CCL2 - blood Chemokine CCL2 - urine Child Creatinine Cross-Sectional Studies Cytokines Cytokines - blood Cytokines - urine Enzyme-Linked Immunosorbent Assay Female Growth factors Humans Hypercalciuria - blood Hypercalciuria - diagnostic imaging Hypercalciuria - immunology Hypercalciuria - urine Interleukin-1beta - blood Interleukin-1beta - urine Interleukin-6 - blood Interleukin-6 - urine Interleukin-8 - blood Interleukin-8 - urine Kidney stones Lumbar Vertebrae - diagnostic imaging Male Medicine Medicine & Public Health Nephrology Pediatrics Plasma Teenagers Transforming Growth Factor beta1 - blood Transforming Growth Factor beta1 - urine Transforming growth factors Tumor necrosis factor Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - urine Tumor necrosis factor-TNF Uric acid Urine Urology Young Adult |
| title | Plasma and urinary levels of cytokines in patients with idiopathic hypercalciuria |
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