The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in cytotoxic T lymphocytes

LL-37 is a human cationic host defense peptide (antimicrobial peptide) belonging to the cathelicidin family of peptides. In this study, LL-37 was shown to kill stimulated CD8 + T cells (Cytotoxic T lymphocytes; CTLs) via apoptosis, while having no cytotoxic effect on non-stimulated CD8 + or CD4 + T...

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Veröffentlicht in:	Experimental cell research 2011-02, Vol.317 (4), p.531-538
Hauptverfasser:	Mader, Jamie S., Marcet-Palacios, Marcelo, Hancock, Robert E.W., Bleackley, R. Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides Apoptosis Apoptosis - drug effects Cellular biology Cytotoxic T lymphocytes Granzyme Granzymes - physiology Host defense peptide Immunology Inflammation Lymphocytes Mice Mice, Inbred C57BL Peptides Receptor Cross-Talk T-Lymphocytes, Cytotoxic - drug effects
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