Epstein–Barr virus‐associated smooth muscle tumors in a composite tissue allograft and a pediatric liver transplant recipient
Epstein–Barr virus (EBV) is known to establish latent infections in B‐lymphocytes that can cause lymphoproliferative disorders particularly in immunocompromised patients. More recently, the development of rare EBV‐associated smooth muscle tumors has been reported in transplant recipients. We herein...
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| Veröffentlicht in: | Transplant infectious disease 2013-10, Vol.15 (5), p.E182-E186 |
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| creator | Conrad, A. Brunet, A.‐S. Hervieu, V. Chauvet, C. Buron, F. Collardeau‐Frachon, S. Rivet, C. Cassier, P. Testelin, S. Lachaux, A. Morelon, E. Thaunat, O. |
| description | Epstein–Barr virus (EBV) is known to establish latent infections in B‐lymphocytes that can cause lymphoproliferative disorders particularly in immunocompromised patients. More recently, the development of rare EBV‐associated smooth muscle tumors has been reported in transplant recipients. We herein describe 2 new cases of EBV‐associated post‐transplant smooth muscle tumors (EBV‐PTSMT), including the first in a facial composite tissue graft recipient. Among the striking features shared by these 2 patients were their young ages, the fact that they were naïve for EBV before the transplantation, that they developed a post‐transplant lymphoproliferative disorder before the diagnosis of EBV‐PTSMT, and that they responded favorably to reduction of immunosuppression. Radiological and histologic features of EBV‐PTSMT are shown. Finally, pathophysiology and therapeutic management of EBV‐PTSMT are discussed based on a comprehensive review of the literature. |
| doi_str_mv | 10.1111/tid.12126 |
| format | Article |
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More recently, the development of rare EBV‐associated smooth muscle tumors has been reported in transplant recipients. We herein describe 2 new cases of EBV‐associated post‐transplant smooth muscle tumors (EBV‐PTSMT), including the first in a facial composite tissue graft recipient. Among the striking features shared by these 2 patients were their young ages, the fact that they were naïve for EBV before the transplantation, that they developed a post‐transplant lymphoproliferative disorder before the diagnosis of EBV‐PTSMT, and that they responded favorably to reduction of immunosuppression. Radiological and histologic features of EBV‐PTSMT are shown. Finally, pathophysiology and therapeutic management of EBV‐PTSMT are discussed based on a comprehensive review of the literature.</description><identifier>ISSN: 1398-2273</identifier><identifier>EISSN: 1399-3062</identifier><identifier>DOI: 10.1111/tid.12126</identifier><identifier>PMID: 24034213</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adult ; Age ; Allografts ; composite tissue allotransplantation ; Epstein-Barr virus ; Epstein-Barr Virus Infections - diagnosis ; Epstein-Barr Virus Infections - etiology ; Epstein-Barr Virus Infections - therapy ; Epstein-Barr Virus Infections - virology ; face transplantation ; Facial Transplantation - adverse effects ; Female ; Herpesvirus 4, Human - genetics ; Herpesvirus 4, Human - immunology ; Herpesvirus 4, Human - isolation & purification ; Humans ; Immunocompromised Host ; Immunosuppression - adverse effects ; Infant ; Liver Transplantation - adverse effects ; Lymphoma, B-Cell - diagnosis ; Lymphoma, B-Cell - etiology ; Lymphoma, B-Cell - therapy ; Male ; Postoperative Complications - diagnosis ; Postoperative Complications - etiology ; Postoperative Complications - therapy ; post‐transplant lymphoproliferative disorders ; post‐transplant smooth muscle tumors ; PTLD ; Smooth Muscle Tumor - diagnosis ; Smooth Muscle Tumor - etiology ; Smooth Muscle Tumor - therapy ; Smooth Muscle Tumor - virology</subject><ispartof>Transplant infectious disease, 2013-10, Vol.15 (5), p.E182-E186</ispartof><rights>2013 John Wiley & Sons A/S</rights><rights>2013 John Wiley & Sons A/S.</rights><rights>2013 Wiley Periodicals, Inc</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftid.12126$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftid.12126$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24034213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conrad, A.</creatorcontrib><creatorcontrib>Brunet, A.‐S.</creatorcontrib><creatorcontrib>Hervieu, V.</creatorcontrib><creatorcontrib>Chauvet, C.</creatorcontrib><creatorcontrib>Buron, F.</creatorcontrib><creatorcontrib>Collardeau‐Frachon, S.</creatorcontrib><creatorcontrib>Rivet, C.</creatorcontrib><creatorcontrib>Cassier, P.</creatorcontrib><creatorcontrib>Testelin, S.</creatorcontrib><creatorcontrib>Lachaux, A.</creatorcontrib><creatorcontrib>Morelon, E.</creatorcontrib><creatorcontrib>Thaunat, O.</creatorcontrib><title>Epstein–Barr virus‐associated smooth muscle tumors in a composite tissue allograft and a pediatric liver transplant recipient</title><title>Transplant infectious disease</title><addtitle>Transpl Infect Dis</addtitle><description>Epstein–Barr virus (EBV) is known to establish latent infections in B‐lymphocytes that can cause lymphoproliferative disorders particularly in immunocompromised patients. More recently, the development of rare EBV‐associated smooth muscle tumors has been reported in transplant recipients. We herein describe 2 new cases of EBV‐associated post‐transplant smooth muscle tumors (EBV‐PTSMT), including the first in a facial composite tissue graft recipient. Among the striking features shared by these 2 patients were their young ages, the fact that they were naïve for EBV before the transplantation, that they developed a post‐transplant lymphoproliferative disorder before the diagnosis of EBV‐PTSMT, and that they responded favorably to reduction of immunosuppression. Radiological and histologic features of EBV‐PTSMT are shown. Finally, pathophysiology and therapeutic management of EBV‐PTSMT are discussed based on a comprehensive review of the literature.</description><subject>Adult</subject><subject>Age</subject><subject>Allografts</subject><subject>composite tissue allotransplantation</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - diagnosis</subject><subject>Epstein-Barr Virus Infections - etiology</subject><subject>Epstein-Barr Virus Infections - therapy</subject><subject>Epstein-Barr Virus Infections - virology</subject><subject>face transplantation</subject><subject>Facial Transplantation - adverse effects</subject><subject>Female</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Herpesvirus 4, Human - immunology</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Immunosuppression - adverse effects</subject><subject>Infant</subject><subject>Liver Transplantation - adverse effects</subject><subject>Lymphoma, B-Cell - diagnosis</subject><subject>Lymphoma, B-Cell - etiology</subject><subject>Lymphoma, B-Cell - therapy</subject><subject>Male</subject><subject>Postoperative Complications - diagnosis</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - therapy</subject><subject>post‐transplant lymphoproliferative disorders</subject><subject>post‐transplant smooth muscle tumors</subject><subject>PTLD</subject><subject>Smooth Muscle Tumor - diagnosis</subject><subject>Smooth Muscle Tumor - etiology</subject><subject>Smooth Muscle Tumor - therapy</subject><subject>Smooth Muscle Tumor - virology</subject><issn>1398-2273</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0c1O3DAQB3CralXowoEXQJZ64RLwVxL7SBdKkZC4wDnyOhMwSuLgcUDc4A0q9Q33SXAX2kNP9cUj-6fRjP6E7HF2yPM5Sr495IKL6gPZ5tKYQrJKfNzUuhCillvkC-IdY7w2ynwmW0IxqQSX2-TldMIEflw___pmY6QPPs64fv5pEYPzNkFLcQgh3dJhRtcDTfMQIlI_UktdGKaAPuVXjzgDtX0fbqLtErVjm8EEbe4RvaO9f4BIU7QjTr0dE43g_ORhTDvkU2d7hN33e0Guv59eLX8UF5dn58vji2KSebMClIHaQOequlZQ6ZUFrSUHEC1ztTZqJfRKOdZVTjpdGqGEcaVsK1F3sjRGLsjBW98phvsZMDWDRwd9ngbCjA1XlSoZr_j_UCUVY4brTL_-Q-_CHMe8SFbSCF1yXWe1_67m1QBtM0U_2PjU_Mkhg6M38Oh7ePr7z1nzO-AmB9xsAm6uzk82hXwFJFuatg</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Conrad, A.</creator><creator>Brunet, A.‐S.</creator><creator>Hervieu, V.</creator><creator>Chauvet, C.</creator><creator>Buron, F.</creator><creator>Collardeau‐Frachon, S.</creator><creator>Rivet, C.</creator><creator>Cassier, P.</creator><creator>Testelin, S.</creator><creator>Lachaux, A.</creator><creator>Morelon, E.</creator><creator>Thaunat, O.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Epstein–Barr virus‐associated smooth muscle tumors in a composite tissue allograft and a pediatric liver transplant recipient</title><author>Conrad, A. ; Brunet, A.‐S. ; Hervieu, V. ; Chauvet, C. ; Buron, F. ; Collardeau‐Frachon, S. ; Rivet, C. ; Cassier, P. ; Testelin, S. ; Lachaux, A. ; Morelon, E. ; Thaunat, O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3126-e49e79efc6774e68bae8831ee2d0c7894b28b4c0f6c3c8592429c53d627f35993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Age</topic><topic>Allografts</topic><topic>composite tissue allotransplantation</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - diagnosis</topic><topic>Epstein-Barr Virus Infections - etiology</topic><topic>Epstein-Barr Virus Infections - therapy</topic><topic>Epstein-Barr Virus Infections - virology</topic><topic>face transplantation</topic><topic>Facial Transplantation - adverse effects</topic><topic>Female</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Herpesvirus 4, Human - immunology</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Immunosuppression - adverse effects</topic><topic>Infant</topic><topic>Liver Transplantation - adverse effects</topic><topic>Lymphoma, B-Cell - diagnosis</topic><topic>Lymphoma, B-Cell - etiology</topic><topic>Lymphoma, B-Cell - therapy</topic><topic>Male</topic><topic>Postoperative Complications - diagnosis</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - therapy</topic><topic>post‐transplant lymphoproliferative disorders</topic><topic>post‐transplant smooth muscle tumors</topic><topic>PTLD</topic><topic>Smooth Muscle Tumor - diagnosis</topic><topic>Smooth Muscle Tumor - etiology</topic><topic>Smooth Muscle Tumor - therapy</topic><topic>Smooth Muscle Tumor - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Conrad, A.</creatorcontrib><creatorcontrib>Brunet, A.‐S.</creatorcontrib><creatorcontrib>Hervieu, V.</creatorcontrib><creatorcontrib>Chauvet, C.</creatorcontrib><creatorcontrib>Buron, F.</creatorcontrib><creatorcontrib>Collardeau‐Frachon, S.</creatorcontrib><creatorcontrib>Rivet, C.</creatorcontrib><creatorcontrib>Cassier, P.</creatorcontrib><creatorcontrib>Testelin, S.</creatorcontrib><creatorcontrib>Lachaux, A.</creatorcontrib><creatorcontrib>Morelon, E.</creatorcontrib><creatorcontrib>Thaunat, O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conrad, A.</au><au>Brunet, A.‐S.</au><au>Hervieu, V.</au><au>Chauvet, C.</au><au>Buron, F.</au><au>Collardeau‐Frachon, S.</au><au>Rivet, C.</au><au>Cassier, P.</au><au>Testelin, S.</au><au>Lachaux, A.</au><au>Morelon, E.</au><au>Thaunat, O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epstein–Barr virus‐associated smooth muscle tumors in a composite tissue allograft and a pediatric liver transplant recipient</atitle><jtitle>Transplant infectious disease</jtitle><addtitle>Transpl Infect Dis</addtitle><date>2013-10</date><risdate>2013</risdate><volume>15</volume><issue>5</issue><spage>E182</spage><epage>E186</epage><pages>E182-E186</pages><issn>1398-2273</issn><eissn>1399-3062</eissn><abstract>Epstein–Barr virus (EBV) is known to establish latent infections in B‐lymphocytes that can cause lymphoproliferative disorders particularly in immunocompromised patients. More recently, the development of rare EBV‐associated smooth muscle tumors has been reported in transplant recipients. We herein describe 2 new cases of EBV‐associated post‐transplant smooth muscle tumors (EBV‐PTSMT), including the first in a facial composite tissue graft recipient. Among the striking features shared by these 2 patients were their young ages, the fact that they were naïve for EBV before the transplantation, that they developed a post‐transplant lymphoproliferative disorder before the diagnosis of EBV‐PTSMT, and that they responded favorably to reduction of immunosuppression. Radiological and histologic features of EBV‐PTSMT are shown. Finally, pathophysiology and therapeutic management of EBV‐PTSMT are discussed based on a comprehensive review of the literature.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24034213</pmid><doi>10.1111/tid.12126</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Age Allografts composite tissue allotransplantation Epstein-Barr virus Epstein-Barr Virus Infections - diagnosis Epstein-Barr Virus Infections - etiology Epstein-Barr Virus Infections - therapy Epstein-Barr Virus Infections - virology face transplantation Facial Transplantation - adverse effects Female Herpesvirus 4, Human - genetics Herpesvirus 4, Human - immunology Herpesvirus 4, Human - isolation & purification Humans Immunocompromised Host Immunosuppression - adverse effects Infant Liver Transplantation - adverse effects Lymphoma, B-Cell - diagnosis Lymphoma, B-Cell - etiology Lymphoma, B-Cell - therapy Male Postoperative Complications - diagnosis Postoperative Complications - etiology Postoperative Complications - therapy post‐transplant lymphoproliferative disorders post‐transplant smooth muscle tumors PTLD Smooth Muscle Tumor - diagnosis Smooth Muscle Tumor - etiology Smooth Muscle Tumor - therapy Smooth Muscle Tumor - virology |
| title | Epstein–Barr virus‐associated smooth muscle tumors in a composite tissue allograft and a pediatric liver transplant recipient |
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