Progressive decline of residual follicle pool after clinical diagnosis of autoimmune ovarian insufficiency
Summary Context In approximately 5–8% patients with primary ovarian insufficiency (POI), the disease is caused by an autoimmune process made evident by the appearance of autoantibodies against steroidogenic enzymes (SCA‐POI). Anti‐müllerian hormone (AMH) is the best marker of the residual follicular...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2012-09, Vol.77 (3), p.453-458 |
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| creator | Falorni, Alberto Brozzetti, Annalisa Aglietti, Maria Chiara Esposito, Raffaella Minarelli, Viviana Morelli, Silvia Sbroma Tomaro, Emilia Marzotti, Stefania |
| description | Summary
Context
In approximately 5–8% patients with primary ovarian insufficiency (POI), the disease is caused by an autoimmune process made evident by the appearance of autoantibodies against steroidogenic enzymes (SCA‐POI). Anti‐müllerian hormone (AMH) is the best marker of the residual follicular pool.
Objective
To evaluate the rate of loss of the residual follicle pool in women with SCA‐POI after clinical diagnosis.
Design and methods
One hundred and thirty‐two women with POI were tested for 21‐hydroxylase autoantibodies, 17α‐hydroxylase autoantibodies and P450scc autoantibodies, and 35 patients with SCA‐POI were identified. AMH was analysed at the time of the first visit in all women with POI, and in follow‐up, serum samples were taken 1–3 years after in 11 women with SCA‐POI and detectable AMH.
Results
12/35 (35%) women with SCA‐POI had AMH levels within the normal range at the time of first sampling, as compared to 6/97 (6%) with idiopathic POI (P |
| doi_str_mv | 10.1111/j.1365-2265.2012.04387.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1464497160</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3377136681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5487-bb733b94e259f46bd4bc77c47c6c785b0b572a6c45798859700b9acf7adbddc23</originalsourceid><addsrcrecordid>eNqNkc2LEzEYh4Mobl39F2RABC8z5juZgwct61ZZVkFFbyHJZJaM6aSbdNb2vzdjawUvmktC3ud58_EDoEKwQWW8HBpEOKsx5qzBEOEGUiJFs7sHFqfCfbCABMIack7PwKOcBwghk1A8BGcYUyQQFgswfEzxJrmc_Z2rOmeDH10V-6ps-W7SoepjCN4GV21iDJXuty5VM-VtKXZe34wx-zwretpGv15Pc4M7nbweKz_mqe-99W60-8fgQa9Ddk-O8zn48vbi83JVX324fLd8fVVbRqWojRGEmJY6zNqectNRY4WwVFhuhWQGGiaw5pYy0UrJWgGhabXthe5M11lMzsGLQ99NireTy1u19tm6EPTo4pQVopzSViAO_41CQrjEQpKCPvsLHeKUxvIQhRhlskVSykLJA2VTzDm5Xm2SX-u0L63UHJ0a1JyQmhNSc3TqV3RqV9SnxwMms3bdSfydVQGeHwGdy-f3SY_W5z8cx4xBTgv36sD98MHt__sCanlxPa-KXx98n7dud_J1-q64IIKpr9eX6tvqPcSrT0y9IT8BQuDD9w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1545891888</pqid></control><display><type>article</type><title>Progressive decline of residual follicle pool after clinical diagnosis of autoimmune ovarian insufficiency</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Falorni, Alberto ; Brozzetti, Annalisa ; Aglietti, Maria Chiara ; Esposito, Raffaella ; Minarelli, Viviana ; Morelli, Silvia ; Sbroma Tomaro, Emilia ; Marzotti, Stefania</creator><creatorcontrib>Falorni, Alberto ; Brozzetti, Annalisa ; Aglietti, Maria Chiara ; Esposito, Raffaella ; Minarelli, Viviana ; Morelli, Silvia ; Sbroma Tomaro, Emilia ; Marzotti, Stefania</creatorcontrib><description>Summary
Context
In approximately 5–8% patients with primary ovarian insufficiency (POI), the disease is caused by an autoimmune process made evident by the appearance of autoantibodies against steroidogenic enzymes (SCA‐POI). Anti‐müllerian hormone (AMH) is the best marker of the residual follicular pool.
Objective
To evaluate the rate of loss of the residual follicle pool in women with SCA‐POI after clinical diagnosis.
Design and methods
One hundred and thirty‐two women with POI were tested for 21‐hydroxylase autoantibodies, 17α‐hydroxylase autoantibodies and P450scc autoantibodies, and 35 patients with SCA‐POI were identified. AMH was analysed at the time of the first visit in all women with POI, and in follow‐up, serum samples were taken 1–3 years after in 11 women with SCA‐POI and detectable AMH.
Results
12/35 (35%) women with SCA‐POI had AMH levels within the normal range at the time of first sampling, as compared to 6/97 (6%) with idiopathic POI (P < 0·001). 11/17 (65%) women with SCA‐POI with <6 years disease duration had normal serum AMH concentration. A progressive decline in AMH concentration was observed at longitudinal follow‐up in all 11 AMH‐positive women with SCA‐POI, at an estimated average rate of 1·6 μg/l AMH/year (corresponding to an average 57% of preserved follicle pool/previous year) (R2 = 0·219, P = 0·028). After 6 years of disease duration, only 1/18 (6%) women with SCA‐POI had detectable levels of AMH, similar to women with idiopathic POI (5/78, 6%).
Conclusion
Most women with SCA‐POI present at clinical diagnosis with a preserved follicle pool that is progressively lost within a few years.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2012.04387.x</identifier><identifier>PMID: 22417127</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Adult ; Anti-Mullerian Hormone - blood ; Autoantibodies - blood ; Autoimmune Diseases - blood ; Autoimmune Diseases - immunology ; Autoimmune Diseases - pathology ; Biological and medical sciences ; Biomarkers - blood ; Endocrinopathies ; Estradiol - blood ; Female ; Follicle Stimulating Hormone - blood ; Fundamental and applied biological sciences. Psychology ; Gonadal Steroid Hormones - immunology ; Humans ; Inhibins - blood ; Luteinizing Hormone - blood ; Medical sciences ; Ovarian Follicle - immunology ; Ovarian Follicle - pathology ; Primary Ovarian Insufficiency - blood ; Primary Ovarian Insufficiency - immunology ; Primary Ovarian Insufficiency - pathology ; Time Factors ; Vertebrates: endocrinology ; Young Adult</subject><ispartof>Clinical endocrinology (Oxford), 2012-09, Vol.77 (3), p.453-458</ispartof><rights>2012 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2012 Blackwell Publishing Ltd.</rights><rights>Copyright © 2012 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5487-bb733b94e259f46bd4bc77c47c6c785b0b572a6c45798859700b9acf7adbddc23</citedby><cites>FETCH-LOGICAL-c5487-bb733b94e259f46bd4bc77c47c6c785b0b572a6c45798859700b9acf7adbddc23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2012.04387.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2012.04387.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26255064$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22417127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Falorni, Alberto</creatorcontrib><creatorcontrib>Brozzetti, Annalisa</creatorcontrib><creatorcontrib>Aglietti, Maria Chiara</creatorcontrib><creatorcontrib>Esposito, Raffaella</creatorcontrib><creatorcontrib>Minarelli, Viviana</creatorcontrib><creatorcontrib>Morelli, Silvia</creatorcontrib><creatorcontrib>Sbroma Tomaro, Emilia</creatorcontrib><creatorcontrib>Marzotti, Stefania</creatorcontrib><title>Progressive decline of residual follicle pool after clinical diagnosis of autoimmune ovarian insufficiency</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Context
In approximately 5–8% patients with primary ovarian insufficiency (POI), the disease is caused by an autoimmune process made evident by the appearance of autoantibodies against steroidogenic enzymes (SCA‐POI). Anti‐müllerian hormone (AMH) is the best marker of the residual follicular pool.
Objective
To evaluate the rate of loss of the residual follicle pool in women with SCA‐POI after clinical diagnosis.
Design and methods
One hundred and thirty‐two women with POI were tested for 21‐hydroxylase autoantibodies, 17α‐hydroxylase autoantibodies and P450scc autoantibodies, and 35 patients with SCA‐POI were identified. AMH was analysed at the time of the first visit in all women with POI, and in follow‐up, serum samples were taken 1–3 years after in 11 women with SCA‐POI and detectable AMH.
Results
12/35 (35%) women with SCA‐POI had AMH levels within the normal range at the time of first sampling, as compared to 6/97 (6%) with idiopathic POI (P < 0·001). 11/17 (65%) women with SCA‐POI with <6 years disease duration had normal serum AMH concentration. A progressive decline in AMH concentration was observed at longitudinal follow‐up in all 11 AMH‐positive women with SCA‐POI, at an estimated average rate of 1·6 μg/l AMH/year (corresponding to an average 57% of preserved follicle pool/previous year) (R2 = 0·219, P = 0·028). After 6 years of disease duration, only 1/18 (6%) women with SCA‐POI had detectable levels of AMH, similar to women with idiopathic POI (5/78, 6%).
Conclusion
Most women with SCA‐POI present at clinical diagnosis with a preserved follicle pool that is progressively lost within a few years.</description><subject>Adult</subject><subject>Anti-Mullerian Hormone - blood</subject><subject>Autoantibodies - blood</subject><subject>Autoimmune Diseases - blood</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - pathology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Endocrinopathies</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadal Steroid Hormones - immunology</subject><subject>Humans</subject><subject>Inhibins - blood</subject><subject>Luteinizing Hormone - blood</subject><subject>Medical sciences</subject><subject>Ovarian Follicle - immunology</subject><subject>Ovarian Follicle - pathology</subject><subject>Primary Ovarian Insufficiency - blood</subject><subject>Primary Ovarian Insufficiency - immunology</subject><subject>Primary Ovarian Insufficiency - pathology</subject><subject>Time Factors</subject><subject>Vertebrates: endocrinology</subject><subject>Young Adult</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2LEzEYh4Mobl39F2RABC8z5juZgwct61ZZVkFFbyHJZJaM6aSbdNb2vzdjawUvmktC3ud58_EDoEKwQWW8HBpEOKsx5qzBEOEGUiJFs7sHFqfCfbCABMIack7PwKOcBwghk1A8BGcYUyQQFgswfEzxJrmc_Z2rOmeDH10V-6ps-W7SoepjCN4GV21iDJXuty5VM-VtKXZe34wx-zwretpGv15Pc4M7nbweKz_mqe-99W60-8fgQa9Ddk-O8zn48vbi83JVX324fLd8fVVbRqWojRGEmJY6zNqectNRY4WwVFhuhWQGGiaw5pYy0UrJWgGhabXthe5M11lMzsGLQ99NireTy1u19tm6EPTo4pQVopzSViAO_41CQrjEQpKCPvsLHeKUxvIQhRhlskVSykLJA2VTzDm5Xm2SX-u0L63UHJ0a1JyQmhNSc3TqV3RqV9SnxwMms3bdSfydVQGeHwGdy-f3SY_W5z8cx4xBTgv36sD98MHt__sCanlxPa-KXx98n7dud_J1-q64IIKpr9eX6tvqPcSrT0y9IT8BQuDD9w</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Falorni, Alberto</creator><creator>Brozzetti, Annalisa</creator><creator>Aglietti, Maria Chiara</creator><creator>Esposito, Raffaella</creator><creator>Minarelli, Viviana</creator><creator>Morelli, Silvia</creator><creator>Sbroma Tomaro, Emilia</creator><creator>Marzotti, Stefania</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201209</creationdate><title>Progressive decline of residual follicle pool after clinical diagnosis of autoimmune ovarian insufficiency</title><author>Falorni, Alberto ; Brozzetti, Annalisa ; Aglietti, Maria Chiara ; Esposito, Raffaella ; Minarelli, Viviana ; Morelli, Silvia ; Sbroma Tomaro, Emilia ; Marzotti, Stefania</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5487-bb733b94e259f46bd4bc77c47c6c785b0b572a6c45798859700b9acf7adbddc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Anti-Mullerian Hormone - blood</topic><topic>Autoantibodies - blood</topic><topic>Autoimmune Diseases - blood</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - pathology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Endocrinopathies</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadal Steroid Hormones - immunology</topic><topic>Humans</topic><topic>Inhibins - blood</topic><topic>Luteinizing Hormone - blood</topic><topic>Medical sciences</topic><topic>Ovarian Follicle - immunology</topic><topic>Ovarian Follicle - pathology</topic><topic>Primary Ovarian Insufficiency - blood</topic><topic>Primary Ovarian Insufficiency - immunology</topic><topic>Primary Ovarian Insufficiency - pathology</topic><topic>Time Factors</topic><topic>Vertebrates: endocrinology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Falorni, Alberto</creatorcontrib><creatorcontrib>Brozzetti, Annalisa</creatorcontrib><creatorcontrib>Aglietti, Maria Chiara</creatorcontrib><creatorcontrib>Esposito, Raffaella</creatorcontrib><creatorcontrib>Minarelli, Viviana</creatorcontrib><creatorcontrib>Morelli, Silvia</creatorcontrib><creatorcontrib>Sbroma Tomaro, Emilia</creatorcontrib><creatorcontrib>Marzotti, Stefania</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Falorni, Alberto</au><au>Brozzetti, Annalisa</au><au>Aglietti, Maria Chiara</au><au>Esposito, Raffaella</au><au>Minarelli, Viviana</au><au>Morelli, Silvia</au><au>Sbroma Tomaro, Emilia</au><au>Marzotti, Stefania</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progressive decline of residual follicle pool after clinical diagnosis of autoimmune ovarian insufficiency</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2012-09</date><risdate>2012</risdate><volume>77</volume><issue>3</issue><spage>453</spage><epage>458</epage><pages>453-458</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Context
In approximately 5–8% patients with primary ovarian insufficiency (POI), the disease is caused by an autoimmune process made evident by the appearance of autoantibodies against steroidogenic enzymes (SCA‐POI). Anti‐müllerian hormone (AMH) is the best marker of the residual follicular pool.
Objective
To evaluate the rate of loss of the residual follicle pool in women with SCA‐POI after clinical diagnosis.
Design and methods
One hundred and thirty‐two women with POI were tested for 21‐hydroxylase autoantibodies, 17α‐hydroxylase autoantibodies and P450scc autoantibodies, and 35 patients with SCA‐POI were identified. AMH was analysed at the time of the first visit in all women with POI, and in follow‐up, serum samples were taken 1–3 years after in 11 women with SCA‐POI and detectable AMH.
Results
12/35 (35%) women with SCA‐POI had AMH levels within the normal range at the time of first sampling, as compared to 6/97 (6%) with idiopathic POI (P < 0·001). 11/17 (65%) women with SCA‐POI with <6 years disease duration had normal serum AMH concentration. A progressive decline in AMH concentration was observed at longitudinal follow‐up in all 11 AMH‐positive women with SCA‐POI, at an estimated average rate of 1·6 μg/l AMH/year (corresponding to an average 57% of preserved follicle pool/previous year) (R2 = 0·219, P = 0·028). After 6 years of disease duration, only 1/18 (6%) women with SCA‐POI had detectable levels of AMH, similar to women with idiopathic POI (5/78, 6%).
Conclusion
Most women with SCA‐POI present at clinical diagnosis with a preserved follicle pool that is progressively lost within a few years.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>22417127</pmid><doi>10.1111/j.1365-2265.2012.04387.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Adult Anti-Mullerian Hormone - blood Autoantibodies - blood Autoimmune Diseases - blood Autoimmune Diseases - immunology Autoimmune Diseases - pathology Biological and medical sciences Biomarkers - blood Endocrinopathies Estradiol - blood Female Follicle Stimulating Hormone - blood Fundamental and applied biological sciences. Psychology Gonadal Steroid Hormones - immunology Humans Inhibins - blood Luteinizing Hormone - blood Medical sciences Ovarian Follicle - immunology Ovarian Follicle - pathology Primary Ovarian Insufficiency - blood Primary Ovarian Insufficiency - immunology Primary Ovarian Insufficiency - pathology Time Factors Vertebrates: endocrinology Young Adult |
| title | Progressive decline of residual follicle pool after clinical diagnosis of autoimmune ovarian insufficiency |
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