A prospective survey of febrile events in hematological malignancies
The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolu...
Gespeichert in:
| Veröffentlicht in: | Annals of hematology 2012-05, Vol.91 (5), p.767-774 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 774 |
|---|---|
| container_issue | 5 |
| container_start_page | 767 |
| container_title | Annals of hematology |
| container_volume | 91 |
| creator | Pagano, L. Caira, M. Rossi, G. Tumbarello, M. Fanci, R. Garzia, M. G. Vianelli, N. Filardi, N. De Fabritiis, P. Beltrame, A. Musso, M. Piccin, A. Cuneo, A. Cattaneo, C. Aloisi, T. Riva, M. Rossi, G. Salvadori, U. Brugiatelli, M. Sannicolò, S. Morselli, M. Bonini, A. Viale, P. Nosari, A. Aversa, F. |
| description | The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs. |
| doi_str_mv | 10.1007/s00277-011-1373-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1464496742</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1464496742</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-b06502dd318fce3eefc0f72b880523fc92306b3dda69fa2174ff0fbf722071c3</originalsourceid><addsrcrecordid>eNqFkUtPwzAQhC0EouXxA7igiBOXwHrtxsmx4i0hcendcpx1SZVHiZNK_fc4agEJCbEXH_absT3D2AWHGw6gbj0AKhUD5zEXSsR4wKZcCoxhlspDNoVMZPEszISdeL8C4JhKPGYTRI4yQT5l9_No3bV-TbYvNxT5odvQNmpd5Cjvyooi2lDT-6hsoneqTd9W7bK0popqU5XLxjS2JH_GjpypPJ3vz1O2eHxY3D3Hr29PL3fz19hKBX2cQzIDLArBU2dJEDkLTmGepjBD4WyGApJcFIVJMmeQK-kcuDwgCIpbccqud7bhxR8D-V7XpbdUVaahdvCay0TKLFES_0dDFEpKxUf06he6aoeuCf_QWYZpAihGiO8gG8LyHTm97sradNvgpMcu9K4LHbrQYxd61FzujYe8puJb8RV-AHAH-LBqltT93Py36ycIhZLz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>992860232</pqid></control><display><type>article</type><title>A prospective survey of febrile events in hematological malignancies</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Pagano, L. ; Caira, M. ; Rossi, G. ; Tumbarello, M. ; Fanci, R. ; Garzia, M. G. ; Vianelli, N. ; Filardi, N. ; De Fabritiis, P. ; Beltrame, A. ; Musso, M. ; Piccin, A. ; Cuneo, A. ; Cattaneo, C. ; Aloisi, T. ; Riva, M. ; Rossi, G. ; Salvadori, U. ; Brugiatelli, M. ; Sannicolò, S. ; Morselli, M. ; Bonini, A. ; Viale, P. ; Nosari, A. ; Aversa, F.</creator><creatorcontrib>Pagano, L. ; Caira, M. ; Rossi, G. ; Tumbarello, M. ; Fanci, R. ; Garzia, M. G. ; Vianelli, N. ; Filardi, N. ; De Fabritiis, P. ; Beltrame, A. ; Musso, M. ; Piccin, A. ; Cuneo, A. ; Cattaneo, C. ; Aloisi, T. ; Riva, M. ; Rossi, G. ; Salvadori, U. ; Brugiatelli, M. ; Sannicolò, S. ; Morselli, M. ; Bonini, A. ; Viale, P. ; Nosari, A. ; Aversa, F. ; Hema e-Chart Group, Italy ; for the Hema e-Chart Group, Italy</creatorcontrib><description>The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs.</description><identifier>ISSN: 0939-5555</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-011-1373-2</identifier><identifier>PMID: 22124621</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Bacterial Infections - complications ; Bacterial Infections - mortality ; Coinfection - complications ; Coinfection - mortality ; Fever - etiology ; Hematologic Neoplasms - complications ; Hematologic Neoplasms - mortality ; Hematology ; Humans ; Medicine ; Medicine & Public Health ; Mycoses - complications ; Mycoses - mortality ; Oncology ; Original Article ; Prospective Studies ; Virus Diseases - complications ; Virus Diseases - mortality</subject><ispartof>Annals of hematology, 2012-05, Vol.91 (5), p.767-774</ispartof><rights>Springer-Verlag 2011</rights><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-b06502dd318fce3eefc0f72b880523fc92306b3dda69fa2174ff0fbf722071c3</citedby><cites>FETCH-LOGICAL-c470t-b06502dd318fce3eefc0f72b880523fc92306b3dda69fa2174ff0fbf722071c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00277-011-1373-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00277-011-1373-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22124621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pagano, L.</creatorcontrib><creatorcontrib>Caira, M.</creatorcontrib><creatorcontrib>Rossi, G.</creatorcontrib><creatorcontrib>Tumbarello, M.</creatorcontrib><creatorcontrib>Fanci, R.</creatorcontrib><creatorcontrib>Garzia, M. G.</creatorcontrib><creatorcontrib>Vianelli, N.</creatorcontrib><creatorcontrib>Filardi, N.</creatorcontrib><creatorcontrib>De Fabritiis, P.</creatorcontrib><creatorcontrib>Beltrame, A.</creatorcontrib><creatorcontrib>Musso, M.</creatorcontrib><creatorcontrib>Piccin, A.</creatorcontrib><creatorcontrib>Cuneo, A.</creatorcontrib><creatorcontrib>Cattaneo, C.</creatorcontrib><creatorcontrib>Aloisi, T.</creatorcontrib><creatorcontrib>Riva, M.</creatorcontrib><creatorcontrib>Rossi, G.</creatorcontrib><creatorcontrib>Salvadori, U.</creatorcontrib><creatorcontrib>Brugiatelli, M.</creatorcontrib><creatorcontrib>Sannicolò, S.</creatorcontrib><creatorcontrib>Morselli, M.</creatorcontrib><creatorcontrib>Bonini, A.</creatorcontrib><creatorcontrib>Viale, P.</creatorcontrib><creatorcontrib>Nosari, A.</creatorcontrib><creatorcontrib>Aversa, F.</creatorcontrib><creatorcontrib>Hema e-Chart Group, Italy</creatorcontrib><creatorcontrib>for the Hema e-Chart Group, Italy</creatorcontrib><title>A prospective survey of febrile events in hematological malignancies</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><addtitle>Ann Hematol</addtitle><description>The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs.</description><subject>Bacterial Infections - complications</subject><subject>Bacterial Infections - mortality</subject><subject>Coinfection - complications</subject><subject>Coinfection - mortality</subject><subject>Fever - etiology</subject><subject>Hematologic Neoplasms - complications</subject><subject>Hematologic Neoplasms - mortality</subject><subject>Hematology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mycoses - complications</subject><subject>Mycoses - mortality</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prospective Studies</subject><subject>Virus Diseases - complications</subject><subject>Virus Diseases - mortality</subject><issn>0939-5555</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtPwzAQhC0EouXxA7igiBOXwHrtxsmx4i0hcendcpx1SZVHiZNK_fc4agEJCbEXH_absT3D2AWHGw6gbj0AKhUD5zEXSsR4wKZcCoxhlspDNoVMZPEszISdeL8C4JhKPGYTRI4yQT5l9_No3bV-TbYvNxT5odvQNmpd5Cjvyooi2lDT-6hsoneqTd9W7bK0popqU5XLxjS2JH_GjpypPJ3vz1O2eHxY3D3Hr29PL3fz19hKBX2cQzIDLArBU2dJEDkLTmGepjBD4WyGApJcFIVJMmeQK-kcuDwgCIpbccqud7bhxR8D-V7XpbdUVaahdvCay0TKLFES_0dDFEpKxUf06he6aoeuCf_QWYZpAihGiO8gG8LyHTm97sradNvgpMcu9K4LHbrQYxd61FzujYe8puJb8RV-AHAH-LBqltT93Py36ycIhZLz</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Pagano, L.</creator><creator>Caira, M.</creator><creator>Rossi, G.</creator><creator>Tumbarello, M.</creator><creator>Fanci, R.</creator><creator>Garzia, M. G.</creator><creator>Vianelli, N.</creator><creator>Filardi, N.</creator><creator>De Fabritiis, P.</creator><creator>Beltrame, A.</creator><creator>Musso, M.</creator><creator>Piccin, A.</creator><creator>Cuneo, A.</creator><creator>Cattaneo, C.</creator><creator>Aloisi, T.</creator><creator>Riva, M.</creator><creator>Rossi, G.</creator><creator>Salvadori, U.</creator><creator>Brugiatelli, M.</creator><creator>Sannicolò, S.</creator><creator>Morselli, M.</creator><creator>Bonini, A.</creator><creator>Viale, P.</creator><creator>Nosari, A.</creator><creator>Aversa, F.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>M7N</scope></search><sort><creationdate>20120501</creationdate><title>A prospective survey of febrile events in hematological malignancies</title><author>Pagano, L. ; Caira, M. ; Rossi, G. ; Tumbarello, M. ; Fanci, R. ; Garzia, M. G. ; Vianelli, N. ; Filardi, N. ; De Fabritiis, P. ; Beltrame, A. ; Musso, M. ; Piccin, A. ; Cuneo, A. ; Cattaneo, C. ; Aloisi, T. ; Riva, M. ; Rossi, G. ; Salvadori, U. ; Brugiatelli, M. ; Sannicolò, S. ; Morselli, M. ; Bonini, A. ; Viale, P. ; Nosari, A. ; Aversa, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-b06502dd318fce3eefc0f72b880523fc92306b3dda69fa2174ff0fbf722071c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Bacterial Infections - complications</topic><topic>Bacterial Infections - mortality</topic><topic>Coinfection - complications</topic><topic>Coinfection - mortality</topic><topic>Fever - etiology</topic><topic>Hematologic Neoplasms - complications</topic><topic>Hematologic Neoplasms - mortality</topic><topic>Hematology</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mycoses - complications</topic><topic>Mycoses - mortality</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prospective Studies</topic><topic>Virus Diseases - complications</topic><topic>Virus Diseases - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pagano, L.</creatorcontrib><creatorcontrib>Caira, M.</creatorcontrib><creatorcontrib>Rossi, G.</creatorcontrib><creatorcontrib>Tumbarello, M.</creatorcontrib><creatorcontrib>Fanci, R.</creatorcontrib><creatorcontrib>Garzia, M. G.</creatorcontrib><creatorcontrib>Vianelli, N.</creatorcontrib><creatorcontrib>Filardi, N.</creatorcontrib><creatorcontrib>De Fabritiis, P.</creatorcontrib><creatorcontrib>Beltrame, A.</creatorcontrib><creatorcontrib>Musso, M.</creatorcontrib><creatorcontrib>Piccin, A.</creatorcontrib><creatorcontrib>Cuneo, A.</creatorcontrib><creatorcontrib>Cattaneo, C.</creatorcontrib><creatorcontrib>Aloisi, T.</creatorcontrib><creatorcontrib>Riva, M.</creatorcontrib><creatorcontrib>Rossi, G.</creatorcontrib><creatorcontrib>Salvadori, U.</creatorcontrib><creatorcontrib>Brugiatelli, M.</creatorcontrib><creatorcontrib>Sannicolò, S.</creatorcontrib><creatorcontrib>Morselli, M.</creatorcontrib><creatorcontrib>Bonini, A.</creatorcontrib><creatorcontrib>Viale, P.</creatorcontrib><creatorcontrib>Nosari, A.</creatorcontrib><creatorcontrib>Aversa, F.</creatorcontrib><creatorcontrib>Hema e-Chart Group, Italy</creatorcontrib><creatorcontrib>for the Hema e-Chart Group, Italy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Annals of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pagano, L.</au><au>Caira, M.</au><au>Rossi, G.</au><au>Tumbarello, M.</au><au>Fanci, R.</au><au>Garzia, M. G.</au><au>Vianelli, N.</au><au>Filardi, N.</au><au>De Fabritiis, P.</au><au>Beltrame, A.</au><au>Musso, M.</au><au>Piccin, A.</au><au>Cuneo, A.</au><au>Cattaneo, C.</au><au>Aloisi, T.</au><au>Riva, M.</au><au>Rossi, G.</au><au>Salvadori, U.</au><au>Brugiatelli, M.</au><au>Sannicolò, S.</au><au>Morselli, M.</au><au>Bonini, A.</au><au>Viale, P.</au><au>Nosari, A.</au><au>Aversa, F.</au><aucorp>Hema e-Chart Group, Italy</aucorp><aucorp>for the Hema e-Chart Group, Italy</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective survey of febrile events in hematological malignancies</atitle><jtitle>Annals of hematology</jtitle><stitle>Ann Hematol</stitle><addtitle>Ann Hematol</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>91</volume><issue>5</issue><spage>767</spage><epage>774</epage><pages>767-774</pages><issn>0939-5555</issn><eissn>1432-0584</eissn><abstract>The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22124621</pmid><doi>10.1007/s00277-011-1373-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0939-5555 |
| ispartof | Annals of hematology, 2012-05, Vol.91 (5), p.767-774 |
| issn | 0939-5555 1432-0584 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1464496742 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Bacterial Infections - complications Bacterial Infections - mortality Coinfection - complications Coinfection - mortality Fever - etiology Hematologic Neoplasms - complications Hematologic Neoplasms - mortality Hematology Humans Medicine Medicine & Public Health Mycoses - complications Mycoses - mortality Oncology Original Article Prospective Studies Virus Diseases - complications Virus Diseases - mortality |
| title | A prospective survey of febrile events in hematological malignancies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T12%3A09%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20prospective%20survey%20of%20febrile%20events%20in%20hematological%20malignancies&rft.jtitle=Annals%20of%20hematology&rft.au=Pagano,%20L.&rft.aucorp=Hema%20e-Chart%20Group,%20Italy&rft.date=2012-05-01&rft.volume=91&rft.issue=5&rft.spage=767&rft.epage=774&rft.pages=767-774&rft.issn=0939-5555&rft.eissn=1432-0584&rft_id=info:doi/10.1007/s00277-011-1373-2&rft_dat=%3Cproquest_cross%3E1464496742%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=992860232&rft_id=info:pmid/22124621&rfr_iscdi=true |