Sin3: Insight into its transcription regulatory functions
Sin3, a large acidic protein, shares structural similarity with the helix-loop-helix dimerization domain of proteins of the Myc family of transcription factors. Sin3/HDAC corepressor complex functions in transcriptional regulation of several genes and is therefore implicated in the regulation of key...
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| Veröffentlicht in: | European journal of cell biology 2013-08, Vol.92 (8-9), p.237-246 |
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| container_end_page | 246 |
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| container_issue | 8-9 |
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| container_title | European journal of cell biology |
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| creator | Kadamb, Rama Mittal, Shilpi Bansal, Nidhi Batra, Harish Saluja, Daman |
| description | Sin3, a large acidic protein, shares structural similarity with the helix-loop-helix dimerization domain of proteins of the Myc family of transcription factors. Sin3/HDAC corepressor complex functions in transcriptional regulation of several genes and is therefore implicated in the regulation of key biological processes. Knockdown studies have confirmed the role of Sin3 in cellular proliferation, differentiation, apoptosis and cell cycle regulation, emphasizing Sin3 as an essential regulator of critical cellular events in normal and pathological processes. The present review covers the diverse functions of this master transcriptional regulator as well as illustrates the redundant and distinct functions of its two mammalian isoforms. |
| doi_str_mv | 10.1016/j.ejcb.2013.09.001 |
| format | Article |
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Sin3/HDAC corepressor complex functions in transcriptional regulation of several genes and is therefore implicated in the regulation of key biological processes. Knockdown studies have confirmed the role of Sin3 in cellular proliferation, differentiation, apoptosis and cell cycle regulation, emphasizing Sin3 as an essential regulator of critical cellular events in normal and pathological processes. 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| ispartof | European journal of cell biology, 2013-08, Vol.92 (8-9), p.237-246 |
| issn | 0171-9335 1618-1298 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Cell Cycle Cell Transformation, Neoplastic - metabolism Co-repressor complex Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism Enzyme Stability Fungal Proteins - chemistry Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Regulation Histone deacetylase Histones - genetics Histones - metabolism Humans Metabolic Networks and Pathways Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein stability Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Sin3 Histone Deacetylase and Corepressor Complex - chemistry Sin3 Histone Deacetylase and Corepressor Complex - genetics Sin3 Histone Deacetylase and Corepressor Complex - metabolism Sin3A Sin3B Transcriptional regulation |
| title | Sin3: Insight into its transcription regulatory functions |
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