In silico simulations of STAT1 and STAT3 inhibitors predict SH2 domain cross-binding specificity

Signal transducers and activators of transcription (STATs) comprise a family of transcription factors that are structurally related and which participate in signaling pathways activated by cytokines, growth factors and pathogens. Activation of STAT proteins is mediated by the highly conserved Src ho...

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Veröffentlicht in:	European journal of pharmacology 2013-11, Vol.720 (1-3), p.38-48
Hauptverfasser:	Szelag, Malgorzata, Sikorski, Krzysztof, Czerwoniec, Anna, Szatkowska, Katarzyna, Wesoly, Joanna, Bluyssen, Hans A.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Binding specificity Cells, Cultured Computer Simulation Cyclic S-Oxides - pharmacology cytokines dimerization Drug validation endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism growth factors Humans Interferon-alpha - pharmacology Interferon-gamma - pharmacology Molecular Docking Simulation Molecular Sequence Data pathogens pharmacology phosphorylation Phosphorylation - drug effects Protein Binding receptors Sequence Alignment signal transduction src Homology Domains STAT-SH2 inhibitors STAT-SH2 modeling STAT1 Transcription Factor - antagonists & inhibitors STAT1 Transcription Factor - metabolism STAT2 Transcription Factor - antagonists & inhibitors STAT2 Transcription Factor - metabolism STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism transcription factors Vidarabine - analogs & derivatives Vidarabine - pharmacology
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