Human fetal substantia nigra grafted to the dopamine-denervated striatum of immunosuppressed rats: evidence for functional reinnervation
Human fetal substantia nigra tissue, obtained following therapeutic termination of first trimester pregnancies, was grafted to cavities overlying the striatum in ciclosporin-treated rats whose nigrostriatal dopamine system had been removed unilaterally by 6-hydroxydopamine. Tyrosine hydroxylase (TH)...
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| Veröffentlicht in: | Neuroscience letters 1986-11, Vol.71 (3), p.271-276 |
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| container_title | Neuroscience letters |
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| creator | Strömberg, Ingrid Bygdeman, Marc Goldstein, Menek Seiger, Åke Olson, Lars |
| description | Human fetal substantia nigra tissue, obtained following therapeutic termination of first trimester pregnancies, was grafted to cavities overlying the striatum in ciclosporin-treated rats whose nigrostriatal dopamine system had been removed unilaterally by 6-hydroxydopamine. Tyrosine hydroxylase (TH) immunocytochemistry revealed large numbers of surviving human substantia nigra neurons that matured and formed TH-positive nerve fibers reinnervating the host rat striatum. Apomorphine-induced rotational behavior in grafted animals was reduced by 70–80% in optimal cases 3–5 months after grafting. Thus human fetal dopamine neurons can correct functional deficits in dopamine-denervated rat hosts. |
| doi_str_mv | 10.1016/0304-3940(86)90632-4 |
| format | Article |
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Tyrosine hydroxylase (TH) immunocytochemistry revealed large numbers of surviving human substantia nigra neurons that matured and formed TH-positive nerve fibers reinnervating the host rat striatum. Apomorphine-induced rotational behavior in grafted animals was reduced by 70–80% in optimal cases 3–5 months after grafting. Thus human fetal dopamine neurons can correct functional deficits in dopamine-denervated rat hosts.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(86)90632-4</identifier><identifier>PMID: 2879264</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Applied sciences ; Biological and medical sciences ; Brain tissue grafting ; Ciclosporin immunosuppression ; Corpus Striatum - physiology ; Dopamine - physiology ; Dopamine neuron ; Embryology: invertebrates and vertebrates. Teratology ; Exact sciences and technology ; Experimental organogenesis ; Fetus ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; Human fetal substantia nigra ; Humans ; Hydroxydopamines ; Organogenesis. Physiological fonctions ; Other techniques and industries ; Oxidopamine ; Parkinson Disease, Secondary - chemically induced ; Parkinson Disease, Secondary - therapy ; Parkinson's disease ; Rat striatum ; Rats ; Rotational behavior ; Substantia Nigra - enzymology ; Substantia Nigra - transplantation ; Tyrosine 3-Monooxygenase - metabolism ; Tyrosine hydroxylase immunocytochemistry ; Xenograft</subject><ispartof>Neuroscience letters, 1986-11, Vol.71 (3), p.271-276</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-1b199d0f8be56d86e98444d3df803972918e2688bb810666e130cbf93c71e0673</citedby><cites>FETCH-LOGICAL-c512t-1b199d0f8be56d86e98444d3df803972918e2688bb810666e130cbf93c71e0673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0304394086906324$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8308766$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8353954$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2879264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strömberg, Ingrid</creatorcontrib><creatorcontrib>Bygdeman, Marc</creatorcontrib><creatorcontrib>Goldstein, Menek</creatorcontrib><creatorcontrib>Seiger, Åke</creatorcontrib><creatorcontrib>Olson, Lars</creatorcontrib><title>Human fetal substantia nigra grafted to the dopamine-denervated striatum of immunosuppressed rats: evidence for functional reinnervation</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Human fetal substantia nigra tissue, obtained following therapeutic termination of first trimester pregnancies, was grafted to cavities overlying the striatum in ciclosporin-treated rats whose nigrostriatal dopamine system had been removed unilaterally by 6-hydroxydopamine. Tyrosine hydroxylase (TH) immunocytochemistry revealed large numbers of surviving human substantia nigra neurons that matured and formed TH-positive nerve fibers reinnervating the host rat striatum. Apomorphine-induced rotational behavior in grafted animals was reduced by 70–80% in optimal cases 3–5 months after grafting. Thus human fetal dopamine neurons can correct functional deficits in dopamine-denervated rat hosts.</description><subject>Animals</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Brain tissue grafting</subject><subject>Ciclosporin immunosuppression</subject><subject>Corpus Striatum - physiology</subject><subject>Dopamine - physiology</subject><subject>Dopamine neuron</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Exact sciences and technology</subject><subject>Experimental organogenesis</subject><subject>Fetus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>Human fetal substantia nigra</subject><subject>Humans</subject><subject>Hydroxydopamines</subject><subject>Organogenesis. Physiological fonctions</subject><subject>Other techniques and industries</subject><subject>Oxidopamine</subject><subject>Parkinson Disease, Secondary - chemically induced</subject><subject>Parkinson Disease, Secondary - therapy</subject><subject>Parkinson's disease</subject><subject>Rat striatum</subject><subject>Rats</subject><subject>Rotational behavior</subject><subject>Substantia Nigra - enzymology</subject><subject>Substantia Nigra - transplantation</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><subject>Tyrosine hydroxylase immunocytochemistry</subject><subject>Xenograft</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVGLFSEcxSWK7e7WNyjwIaIepnR0HN2HIJatDRZ6qWdx9G8ZM3pT50LfoI-d073cx-hBRM7vHPX8EXpGyRtKqHhLGOEdU5y8kuK1IoL1HX-AdlSOfTeqsX-IdmfkMbos5QchZKADv0AXvRxVL_gO_b5bFxOxh2pmXNapVBNrMDiGb9ngtnwFh2vC9Ttgl_ZmCRE6BxHywWxSqTmYui44eRyWZY2prPt9hlKamE0t1xgOoRksYJ8y9mu0NaTYrssQ4jGnnZ-gR97MBZ6e9iv09cPtl5u77v7zx0837-87O9C-dnSiSjni5QSDcFKAkpxzx5yXhLVPKyqhF1JOk6RECAGUETt5xexIgYiRXaGXx9x9Tj9XKFUvoViYZxMhrUVTLtigRtVAfgRtTqVk8Hqfw2LyL02J3gagt3b11q6WQv8dgObN9vyUv04LuLPp1HjTX5x0U6yZfTbRhnLGJBuYGv4DI3IUomHvjhi0yg4Bsi42bF27kMFW7VL493P_AC__sNQ</recordid><startdate>19861121</startdate><enddate>19861121</enddate><creator>Strömberg, Ingrid</creator><creator>Bygdeman, Marc</creator><creator>Goldstein, Menek</creator><creator>Seiger, Åke</creator><creator>Olson, Lars</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19861121</creationdate><title>Human fetal substantia nigra grafted to the dopamine-denervated striatum of immunosuppressed rats: evidence for functional reinnervation</title><author>Strömberg, Ingrid ; Bygdeman, Marc ; Goldstein, Menek ; Seiger, Åke ; Olson, Lars</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-1b199d0f8be56d86e98444d3df803972918e2688bb810666e130cbf93c71e0673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Brain tissue grafting</topic><topic>Ciclosporin immunosuppression</topic><topic>Corpus Striatum - physiology</topic><topic>Dopamine - physiology</topic><topic>Dopamine neuron</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Exact sciences and technology</topic><topic>Experimental organogenesis</topic><topic>Fetus</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gestational Age</topic><topic>Human fetal substantia nigra</topic><topic>Humans</topic><topic>Hydroxydopamines</topic><topic>Organogenesis. Physiological fonctions</topic><topic>Other techniques and industries</topic><topic>Oxidopamine</topic><topic>Parkinson Disease, Secondary - chemically induced</topic><topic>Parkinson Disease, Secondary - therapy</topic><topic>Parkinson's disease</topic><topic>Rat striatum</topic><topic>Rats</topic><topic>Rotational behavior</topic><topic>Substantia Nigra - enzymology</topic><topic>Substantia Nigra - transplantation</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><topic>Tyrosine hydroxylase immunocytochemistry</topic><topic>Xenograft</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strömberg, Ingrid</creatorcontrib><creatorcontrib>Bygdeman, Marc</creatorcontrib><creatorcontrib>Goldstein, Menek</creatorcontrib><creatorcontrib>Seiger, Åke</creatorcontrib><creatorcontrib>Olson, Lars</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strömberg, Ingrid</au><au>Bygdeman, Marc</au><au>Goldstein, Menek</au><au>Seiger, Åke</au><au>Olson, Lars</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human fetal substantia nigra grafted to the dopamine-denervated striatum of immunosuppressed rats: evidence for functional reinnervation</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1986-11-21</date><risdate>1986</risdate><volume>71</volume><issue>3</issue><spage>271</spage><epage>276</epage><pages>271-276</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Human fetal substantia nigra tissue, obtained following therapeutic termination of first trimester pregnancies, was grafted to cavities overlying the striatum in ciclosporin-treated rats whose nigrostriatal dopamine system had been removed unilaterally by 6-hydroxydopamine. Tyrosine hydroxylase (TH) immunocytochemistry revealed large numbers of surviving human substantia nigra neurons that matured and formed TH-positive nerve fibers reinnervating the host rat striatum. Apomorphine-induced rotational behavior in grafted animals was reduced by 70–80% in optimal cases 3–5 months after grafting. Thus human fetal dopamine neurons can correct functional deficits in dopamine-denervated rat hosts.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>2879264</pmid><doi>10.1016/0304-3940(86)90632-4</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1986-11, Vol.71 (3), p.271-276 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Applied sciences Biological and medical sciences Brain tissue grafting Ciclosporin immunosuppression Corpus Striatum - physiology Dopamine - physiology Dopamine neuron Embryology: invertebrates and vertebrates. Teratology Exact sciences and technology Experimental organogenesis Fetus Fundamental and applied biological sciences. Psychology Gestational Age Human fetal substantia nigra Humans Hydroxydopamines Organogenesis. Physiological fonctions Other techniques and industries Oxidopamine Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - therapy Parkinson's disease Rat striatum Rats Rotational behavior Substantia Nigra - enzymology Substantia Nigra - transplantation Tyrosine 3-Monooxygenase - metabolism Tyrosine hydroxylase immunocytochemistry Xenograft |
| title | Human fetal substantia nigra grafted to the dopamine-denervated striatum of immunosuppressed rats: evidence for functional reinnervation |
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