RGD-based PET tracers for imaging receptor integrin αvβ3 expression
Positron emission tomography (PET) imaging of receptor integrin αvβ3 expression may play a key role in the early detection of cancer and cardiovascular diseases, monitoring disease progression, evaluating therapeutic response, and aiding anti‐angiogenic drugs discovery and development. The last deca...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 2013-05, Vol.56 (5), p.264-279 |
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| creator | Cai, Hancheng Conti, Peter S |
| description | Positron emission tomography (PET) imaging of receptor integrin αvβ3 expression may play a key role in the early detection of cancer and cardiovascular diseases, monitoring disease progression, evaluating therapeutic response, and aiding anti‐angiogenic drugs discovery and development. The last decade has seen the development of new PET tracers for in vivo imaging of integrin αvβ3 expression along with advances in PET chemistry. In this review, we will focus on the radiochemistry development of PET tracers based on arginine–glycine–aspartic acid (RGD) peptide, present an overview of general strategies for preparing RGD‐based PET tracers, and review the recent advances in preparations of 18F‐labeled, 64Cu‐labeled, and 68Ga‐labeled RGD tracers, RGD‐based PET multivalent probes, and RGD‐based PET multimodality probes for imaging receptor integrin αvβ3 expression.
The last decade has seen the development of new PET tracers for in vivo imaging of integrin αvβ3 expression along with advances in PET chemistry. In this review, we will focus on radiochemistry development of PET tracers based on arginine‐glycine‐aspartic acid (RGD) peptide, and present an overview of general strategies for preparing RGD based PET tracers, review the recent advances in preparations of 18F, 64Cu, and 68Ga labeled RGD tracers, RGD‐based PET multivalent probes, and RGD‐based PET multimodality probes for imaging receptor integrin αvβ3 expression. |
| doi_str_mv | 10.1002/jlcr.2999 |
| format | Article |
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The last decade has seen the development of new PET tracers for in vivo imaging of integrin αvβ3 expression along with advances in PET chemistry. In this review, we will focus on radiochemistry development of PET tracers based on arginine‐glycine‐aspartic acid (RGD) peptide, and present an overview of general strategies for preparing RGD based PET tracers, review the recent advances in preparations of 18F, 64Cu, and 68Ga labeled RGD tracers, RGD‐based PET multivalent probes, and RGD‐based PET multimodality probes for imaging receptor integrin αvβ3 expression.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.2999</identifier><identifier>PMID: 24285371</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; Humans ; integrin ; Integrin alphaVbeta3 - metabolism ; Isotope Labeling ; Oligopeptides - chemical synthesis ; Oligopeptides - pharmacology ; PET imaging ; Positron-Emission Tomography ; radiochemistry ; Radiopharmaceuticals - chemical synthesis ; Radiopharmaceuticals - pharmacology ; RGD</subject><ispartof>Journal of labelled compounds & radiopharmaceuticals, 2013-05, Vol.56 (5), p.264-279</ispartof><rights>Copyright © 2013 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjlcr.2999$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjlcr.2999$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24285371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Hancheng</creatorcontrib><creatorcontrib>Conti, Peter S</creatorcontrib><title>RGD-based PET tracers for imaging receptor integrin αvβ3 expression</title><title>Journal of labelled compounds & radiopharmaceuticals</title><addtitle>J. Label Compd. Radiopharm</addtitle><description>Positron emission tomography (PET) imaging of receptor integrin αvβ3 expression may play a key role in the early detection of cancer and cardiovascular diseases, monitoring disease progression, evaluating therapeutic response, and aiding anti‐angiogenic drugs discovery and development. The last decade has seen the development of new PET tracers for in vivo imaging of integrin αvβ3 expression along with advances in PET chemistry. In this review, we will focus on the radiochemistry development of PET tracers based on arginine–glycine–aspartic acid (RGD) peptide, present an overview of general strategies for preparing RGD‐based PET tracers, and review the recent advances in preparations of 18F‐labeled, 64Cu‐labeled, and 68Ga‐labeled RGD tracers, RGD‐based PET multivalent probes, and RGD‐based PET multimodality probes for imaging receptor integrin αvβ3 expression.
The last decade has seen the development of new PET tracers for in vivo imaging of integrin αvβ3 expression along with advances in PET chemistry. In this review, we will focus on radiochemistry development of PET tracers based on arginine‐glycine‐aspartic acid (RGD) peptide, and present an overview of general strategies for preparing RGD based PET tracers, review the recent advances in preparations of 18F, 64Cu, and 68Ga labeled RGD tracers, RGD‐based PET multivalent probes, and RGD‐based PET multimodality probes for imaging receptor integrin αvβ3 expression.</description><subject>Animals</subject><subject>Humans</subject><subject>integrin</subject><subject>Integrin alphaVbeta3 - metabolism</subject><subject>Isotope Labeling</subject><subject>Oligopeptides - chemical synthesis</subject><subject>Oligopeptides - pharmacology</subject><subject>PET imaging</subject><subject>Positron-Emission Tomography</subject><subject>radiochemistry</subject><subject>Radiopharmaceuticals - chemical synthesis</subject><subject>Radiopharmaceuticals - pharmacology</subject><subject>RGD</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMtOwkAUnRiNILrwB0yXbgrzaqezNBVQg0oIRneTaXtLqqWtM0Xhs_RD-CbbgKzuzT2P3HMQuiS4TzCmg_c8Nn0qpTxCXYKldAnj_Bh1MfOpywPMOujM2neMG4zzU9ShnAYeE6SLhrPxrRtpC4kzHc6d2ugYjHXS0jjZUi-yYuEYiKGq20NRw8JkhbP9-dr-MgfWlQFrs7I4Ryepzi1c7GcPvYyG8_DOnTyP78ObiZtRzJu3dCQikMQnPqNEJDHBmidYEhEz6snAxylgGnBNA50ywSQnmIHvcRakOgo066HrnW9lys8V2FotMxtDnusCypVVhPtU-F7j0VCv9tRVtIREVabJYzbqP3pDGOwI31kOmwNOsGo7VW2nqu1UPUzCWbs0CnenyGwN64NCmw_lCyY89fo0Vm_hSODpo1QB-wNjOHee</recordid><startdate>20130515</startdate><enddate>20130515</enddate><creator>Cai, Hancheng</creator><creator>Conti, Peter S</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20130515</creationdate><title>RGD-based PET tracers for imaging receptor integrin αvβ3 expression</title><author>Cai, Hancheng ; Conti, Peter S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2049-1ab7be916163217dc10a4d0917c3259860fe0284a28af37394103e65438fab8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Humans</topic><topic>integrin</topic><topic>Integrin alphaVbeta3 - metabolism</topic><topic>Isotope Labeling</topic><topic>Oligopeptides - chemical synthesis</topic><topic>Oligopeptides - pharmacology</topic><topic>PET imaging</topic><topic>Positron-Emission Tomography</topic><topic>radiochemistry</topic><topic>Radiopharmaceuticals - chemical synthesis</topic><topic>Radiopharmaceuticals - pharmacology</topic><topic>RGD</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Hancheng</creatorcontrib><creatorcontrib>Conti, Peter S</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Hancheng</au><au>Conti, Peter S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RGD-based PET tracers for imaging receptor integrin αvβ3 expression</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><addtitle>J. Label Compd. Radiopharm</addtitle><date>2013-05-15</date><risdate>2013</risdate><volume>56</volume><issue>5</issue><spage>264</spage><epage>279</epage><pages>264-279</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>Positron emission tomography (PET) imaging of receptor integrin αvβ3 expression may play a key role in the early detection of cancer and cardiovascular diseases, monitoring disease progression, evaluating therapeutic response, and aiding anti‐angiogenic drugs discovery and development. The last decade has seen the development of new PET tracers for in vivo imaging of integrin αvβ3 expression along with advances in PET chemistry. In this review, we will focus on the radiochemistry development of PET tracers based on arginine–glycine–aspartic acid (RGD) peptide, present an overview of general strategies for preparing RGD‐based PET tracers, and review the recent advances in preparations of 18F‐labeled, 64Cu‐labeled, and 68Ga‐labeled RGD tracers, RGD‐based PET multivalent probes, and RGD‐based PET multimodality probes for imaging receptor integrin αvβ3 expression.
The last decade has seen the development of new PET tracers for in vivo imaging of integrin αvβ3 expression along with advances in PET chemistry. In this review, we will focus on radiochemistry development of PET tracers based on arginine‐glycine‐aspartic acid (RGD) peptide, and present an overview of general strategies for preparing RGD based PET tracers, review the recent advances in preparations of 18F, 64Cu, and 68Ga labeled RGD tracers, RGD‐based PET multivalent probes, and RGD‐based PET multimodality probes for imaging receptor integrin αvβ3 expression.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24285371</pmid><doi>10.1002/jlcr.2999</doi><tpages>16</tpages></addata></record> |
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| ispartof | Journal of labelled compounds & radiopharmaceuticals, 2013-05, Vol.56 (5), p.264-279 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Humans integrin Integrin alphaVbeta3 - metabolism Isotope Labeling Oligopeptides - chemical synthesis Oligopeptides - pharmacology PET imaging Positron-Emission Tomography radiochemistry Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - pharmacology RGD |
| title | RGD-based PET tracers for imaging receptor integrin αvβ3 expression |
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