Large-scale preparation of (13) C-labeled 2-(phenylthio)acetic acid and the corresponding labeled sulfoxides and sulfones

We have developed large-scale efficient procedures for the conversion of commercially available [(13) C]- or [(2) H3 ,(13) C]methanol and (13) CO2 or (13) C-labeled bromoacetic acid to 2-(phenylthio)[1,2-(13) C2 ]-, [1-(13) C]-, and [2-(13) C]acetic acid. The resulting derivatives are versatile, che...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 2013-02, Vol.56 (2), p.31-35
Hauptverfasser:	Martinez, Rodolfo A, Glass, David R, Ortiz, Erick G, Alvarez, Marc A, Juarez, Ernesto, Lodwig, Siegfried N, Unkefer, Clifford J
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon Isotopes - chemical synthesis Glycolates - chemical synthesis Isotope Labeling - methods Sulfones - chemical synthesis Sulfoxides - chemical synthesis
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