Synthesis of stable isotope labeled anacetrapib, its major metabolites and [14C]anacetrapib

Cholesteryl ester transfer protein inhibitors are an important class of compounds designed to treat hypocholesterolemia and prevent cardiovascular disease. Anacetrapib (MK‐0859) is currently in phase III trials for the treatment of elevated cholesterol levels and prevention of cardiovascular disease...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 2013-10, Vol.56 (12), p.600-608
Hauptverfasser:	Kuethe, Jeffrey T., Soli, Eric D., Royster, Pernilla, Quinn, Catherine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	anacetrapib Anticholesteremic Agents - chemical synthesis Carbon Radioisotopes - chemistry Cardiovascular disease CETP Cholesterol internal standard Isotope Labeling Metabolites MK-0859 Oxazolidinones - chemical synthesis Radiopharmaceuticals - chemical synthesis
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