Relationship of octanol/water partition coefficient and molecular weight to cellular permeability and partitioning in S49 lymphoma cells

We have used modified standard methods and derived new formulae to quantitate cell permeability (P), cell/media partitioning (λ), and intracellular sequestration or binding rate constants (m) for cultured S49 murine lymphoma cells in suspension. Using 15 standard compounds and anticancer drugs, we f...

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Veröffentlicht in:	Pharmaceutical research 1984-11, Vol.1 (6), p.259-266
Hauptverfasser:	LEVIN, V. A, DOLGINOW, D, LANDAHL, H. D, YORKE, C, CSEJTEY, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences General aspects Medical sciences Pharmacology. Drug treatments
Online-Zugang:	Volltext
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