Combined Lewis acid and Brønsted acid-mediated reactivity of glycosyl trichloroacetimidate donors

•Carboxylic acids were proposed as biomimetic catalysts for glycosylation reactions.•‘Weaker’ acids reacted with the glycosyl donor to form the glycosyl ester.•Rate difference among five of these esterification reactions was ∼104.•Mg2+ ions were found to inhibit esterification and allow glycosylatio...

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Veröffentlicht in:	Carbohydrate research 2013-12, Vol.382, p.36-42
Hauptverfasser:	Gould, Nathan D., Liana Allen, C., Nam, Brandon C., Schepartz, Alanna, Miller, Scott J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - chemistry Biomimetic Biomimetics Catalysis catalysts Catalytic Chemistry Techniques, Synthetic - methods Chloroacetates - chemistry enzymes Glycosylation Kinetics Lewis acids Lewis Acids - chemistry Magnesium Magnesium - chemistry Schmidt variance
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