Dental stem cells and their promising role in neural regeneration: an update
Introduction Stem cell-based therapies are considered to be a promising treatment method for several clinical conditions such as Alzheimer's disease, Parkinson's disease, spinal cord injury, and many others. However, the ideal stem cell type for stem cell-based therapy remains to be elucid...
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| Veröffentlicht in: | Clinical oral investigations 2013-12, Vol.17 (9), p.1969-1983 |
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| container_end_page | 1983 |
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| container_issue | 9 |
| container_start_page | 1969 |
| container_title | Clinical oral investigations |
| container_volume | 17 |
| creator | Martens, W. Bronckaers, A. Politis, C. Jacobs, R. Lambrichts, I. |
| description | Introduction
Stem cell-based therapies are considered to be a promising treatment method for several clinical conditions such as Alzheimer's disease, Parkinson's disease, spinal cord injury, and many others. However, the ideal stem cell type for stem cell-based therapy remains to be elucidated.
Discussion
Stem cells are present in a variety of tissues in the embryonic and adult human body. Both embryonic and adult stem cells have their advantages and disadvantages concerning the isolation method, ethical issues, or differentiation potential. The most described adult stem cell population is the mesenchymal stem cells due to their multi-lineage (trans)differentiation potential, high proliferative capacity, and promising therapeutic values. Recently, five different cell populations with mesenchymal stem cell characteristics were identified in dental tissues: dental pulp stem cells, stem cells from human exfoliated deciduous teeth, periodontal ligament stem cells, dental follicle precursor cells, and stem cells from apical papilla.
Conclusion
Each dental stem cell population possesses specific characteristics and advantages which will be summarized in this review. Furthermore, the neural characteristics of dental pulp stem cells and their potential role in (peripheral) neural regeneration will be discussed. |
| doi_str_mv | 10.1007/s00784-013-1030-3 |
| format | Article |
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Stem cell-based therapies are considered to be a promising treatment method for several clinical conditions such as Alzheimer's disease, Parkinson's disease, spinal cord injury, and many others. However, the ideal stem cell type for stem cell-based therapy remains to be elucidated.
Discussion
Stem cells are present in a variety of tissues in the embryonic and adult human body. Both embryonic and adult stem cells have their advantages and disadvantages concerning the isolation method, ethical issues, or differentiation potential. The most described adult stem cell population is the mesenchymal stem cells due to their multi-lineage (trans)differentiation potential, high proliferative capacity, and promising therapeutic values. Recently, five different cell populations with mesenchymal stem cell characteristics were identified in dental tissues: dental pulp stem cells, stem cells from human exfoliated deciduous teeth, periodontal ligament stem cells, dental follicle precursor cells, and stem cells from apical papilla.
Conclusion
Each dental stem cell population possesses specific characteristics and advantages which will be summarized in this review. Furthermore, the neural characteristics of dental pulp stem cells and their potential role in (peripheral) neural regeneration will be discussed.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-013-1030-3</identifier><identifier>PMID: 23846214</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Dentistry ; Humans ; Medicine ; Nerve Regeneration ; Review ; Stem Cells - cytology ; Tooth - cytology ; Tooth - growth & development</subject><ispartof>Clinical oral investigations, 2013-12, Vol.17 (9), p.1969-1983</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-5ae0005d338977e36d177250b6efa274a0de068faec93ed208547b4b30757f813</citedby><cites>FETCH-LOGICAL-c372t-5ae0005d338977e36d177250b6efa274a0de068faec93ed208547b4b30757f813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-013-1030-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-013-1030-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23846214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martens, W.</creatorcontrib><creatorcontrib>Bronckaers, A.</creatorcontrib><creatorcontrib>Politis, C.</creatorcontrib><creatorcontrib>Jacobs, R.</creatorcontrib><creatorcontrib>Lambrichts, I.</creatorcontrib><title>Dental stem cells and their promising role in neural regeneration: an update</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Introduction
Stem cell-based therapies are considered to be a promising treatment method for several clinical conditions such as Alzheimer's disease, Parkinson's disease, spinal cord injury, and many others. However, the ideal stem cell type for stem cell-based therapy remains to be elucidated.
Discussion
Stem cells are present in a variety of tissues in the embryonic and adult human body. Both embryonic and adult stem cells have their advantages and disadvantages concerning the isolation method, ethical issues, or differentiation potential. The most described adult stem cell population is the mesenchymal stem cells due to their multi-lineage (trans)differentiation potential, high proliferative capacity, and promising therapeutic values. Recently, five different cell populations with mesenchymal stem cell characteristics were identified in dental tissues: dental pulp stem cells, stem cells from human exfoliated deciduous teeth, periodontal ligament stem cells, dental follicle precursor cells, and stem cells from apical papilla.
Conclusion
Each dental stem cell population possesses specific characteristics and advantages which will be summarized in this review. Furthermore, the neural characteristics of dental pulp stem cells and their potential role in (peripheral) neural regeneration will be discussed.</description><subject>Animals</subject><subject>Dentistry</subject><subject>Humans</subject><subject>Medicine</subject><subject>Nerve Regeneration</subject><subject>Review</subject><subject>Stem Cells - cytology</subject><subject>Tooth - cytology</subject><subject>Tooth - growth & development</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kEtLxDAUhYMozjj6A9xIwI2b6s2jTetOxicMuNF1SNvbsUObjkm78N-b2lFEcJMbyHdOzj2EnDK4ZADqyocjlREwETEQEIk9MmdSJJFQiu1_3XmUZCmbkSPvNwBMJkockhkXqUw4k3OyukXbm4b6HltaYNN4amxJ-zesHd26rq19bdfUdQ3S2lKLgwu0wzVadKavO3sdBHTYlqbHY3JQmcbjyW4uyOv93cvyMVo9Pzwtb1ZRIRTvo9ggAMSlEGmmFIqkZErxGPIEK8OVNFAiJGllsMgElhzSWKpc5gJUrKqUiQW5mHxDwPcBfa9DzDG8sdgNXrNxuTSTIg7o-R900w3OhnQjxRKeAReBYhNVuM57h5Xeuro17kMz0GPVeqpah6r1WLUeNWc75yFvsfxRfHcbAD4BPjzZNbpfX__r-gkGBIcb</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Martens, W.</creator><creator>Bronckaers, A.</creator><creator>Politis, C.</creator><creator>Jacobs, R.</creator><creator>Lambrichts, I.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20131201</creationdate><title>Dental stem cells and their promising role in neural regeneration: an update</title><author>Martens, W. ; Bronckaers, A. ; Politis, C. ; Jacobs, R. ; Lambrichts, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-5ae0005d338977e36d177250b6efa274a0de068faec93ed208547b4b30757f813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Dentistry</topic><topic>Humans</topic><topic>Medicine</topic><topic>Nerve Regeneration</topic><topic>Review</topic><topic>Stem Cells - cytology</topic><topic>Tooth - cytology</topic><topic>Tooth - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martens, W.</creatorcontrib><creatorcontrib>Bronckaers, A.</creatorcontrib><creatorcontrib>Politis, C.</creatorcontrib><creatorcontrib>Jacobs, R.</creatorcontrib><creatorcontrib>Lambrichts, I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martens, W.</au><au>Bronckaers, A.</au><au>Politis, C.</au><au>Jacobs, R.</au><au>Lambrichts, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dental stem cells and their promising role in neural regeneration: an update</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>17</volume><issue>9</issue><spage>1969</spage><epage>1983</epage><pages>1969-1983</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Introduction
Stem cell-based therapies are considered to be a promising treatment method for several clinical conditions such as Alzheimer's disease, Parkinson's disease, spinal cord injury, and many others. However, the ideal stem cell type for stem cell-based therapy remains to be elucidated.
Discussion
Stem cells are present in a variety of tissues in the embryonic and adult human body. Both embryonic and adult stem cells have their advantages and disadvantages concerning the isolation method, ethical issues, or differentiation potential. The most described adult stem cell population is the mesenchymal stem cells due to their multi-lineage (trans)differentiation potential, high proliferative capacity, and promising therapeutic values. Recently, five different cell populations with mesenchymal stem cell characteristics were identified in dental tissues: dental pulp stem cells, stem cells from human exfoliated deciduous teeth, periodontal ligament stem cells, dental follicle precursor cells, and stem cells from apical papilla.
Conclusion
Each dental stem cell population possesses specific characteristics and advantages which will be summarized in this review. Furthermore, the neural characteristics of dental pulp stem cells and their potential role in (peripheral) neural regeneration will be discussed.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23846214</pmid><doi>10.1007/s00784-013-1030-3</doi><tpages>15</tpages></addata></record> |
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| source | MEDLINE; SpringerLink (Online service) |
| subjects | Animals Dentistry Humans Medicine Nerve Regeneration Review Stem Cells - cytology Tooth - cytology Tooth - growth & development |
| title | Dental stem cells and their promising role in neural regeneration: an update |
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