Preclinical anticancer effects and toxicologic assessment of hepatic artery infusion of fine-powder cisplatin with lipiodol in vivo

We conducted an in vivo study to evaluate the anticancer effect and toxicity of finepowder cisplatin suspended in lipiodol (fCDDP/LPD suspension) after a single administration of three different doses to rats via the intrahepatic artery after transplantation of rat ascites hepatoma cells. The toxici...

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Veröffentlicht in:	Drug Discoveries & Therapeutics 2013/10/31, Vol.7(5), pp.201-208
Hauptverfasser:	Yamaguchi, Toshiya, Nakajima, Naoko, Nakamura, Iwao, Mashiba, Hiroko, Kawashiro, Takashi, Ebara, Keiko, Ichimura, Eiji, Nishimura, Chihiro, Okamoto, Kazuya, Ichikawa, Yuh-ichiro, Ichida, Takafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - toxicity Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cisplatin - administration & dosage Dose-Response Relationship, Drug Ethiodized Oil - administration & dosage fine-powder cisplatin Hepatic Artery Hepatocellular carcinoma lipiodol Liver Neoplasms - drug therapy Liver Neoplasms - pathology Male Neoplasm Transplantation Particle Size Powders Rats Toxicity Tests transcatheter arterial chemoembolization Treatment Outcome
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