Sexual dysfunction in pre-menopausal diabetic women: clinical, metabolic, psychological, cardiovascular, and neurophysiologic correlates
An increased prevalence of female sexual dysfunction (FSD) has been reported in women with diabetes mellitus (DM). Our aim was to evaluate correlates (psychological, cardiovascular, and neurophysiologic) of FSD in DM women without chronic diabetic complications. Female Sexual Function Index (FSFI),...
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| Veröffentlicht in: | Acta diabetologica 2013-12, Vol.50 (6), p.911-917 |
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| creator | Cortelazzi, Donatella Marconi, Annamaria Guazzi, Marco Cristina, Maurizio Zecchini, Barbara Veronelli, Annamaria Cattalini, Claudio Innocenti, Alessandro Bosco, Giovanna Pontiroli, Antonio E. |
| description | An increased prevalence of female sexual dysfunction (FSD) has been reported in women with diabetes mellitus (DM). Our aim was to evaluate correlates (psychological, cardiovascular, and neurophysiologic) of FSD in DM women without chronic diabetic complications. Female Sexual Function Index (FSFI), Beck Depression Inventory (BDI), Michigan Diabetic Neuropathy Index (DNI), and the symptoms of diabetic neuropathy (SDN) questionnaires, metabolic variables, endothelial vascular function (flow-mediated dilation, FMD), echocardiography, and electromyography were studied. 109 pre-menopausal women (18–50 years) [48 with DM (14 type 1 DM, 34 type 2 DM, duration 12.6 ± 1.91 years), and 61 healthy women] received the above questionnaires; physical activity, smoking habits, parity, BMI, waist circumference, HOMA-IR index, fibrinogen, cholesterol (total, HDL, LDL), triglycerides, HbA1c, high-sensitivity C-reactive protein, total testosterone, and estradiol were measured; echocardiography, assessment of intima-media thickness (IMT), FMD, ECG (heart rate and Qtc, indexes of sympathetic activity), and electromyography were performed. FSFI total score and score for arousal, lubrication, and orgasm domains were lower in DM women than in controls (
P
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| doi_str_mv | 10.1007/s00592-013-0482-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1462186962</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3137126341</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-9f280c1dfa651e63fbfc2c6aec9c6bfb2b1fac73eef1db052d7220372befd80e3</originalsourceid><addsrcrecordid>eNp1kc2KFDEYRYMoTs_oA7iRgBsXHc1P_bqTwVFhwIW6Dknqy0yGVFImFe1-Ax_bNDWKCK4CuefeBA5Czxh9xSjtX2dK25ETygShzcDJ4QHasUZw0nIhHqIdHRtK2oaPZ-g85ztKGe_F8BidcdH1fdu0O_TzMxyK8ng6ZluCWV0M2AW8JCAzhLiokk-pUxpWZ_CPWG_fYONdcEb5PZ5hVTp6Z_Z4yUdzG3282RKj0uTid5VN8SrtsQoTDlBSXG6P2W0cNjEl8GqF_AQ9sspneHp_XqCvV---XH4g15_ef7x8e02M6PlKRssHathkVdcy6ITV1nDTKTCj6bTVXDOrTC8ALJs0bfnUc05rVYOdBgriAr3cdpcUvxXIq5xdNuC9ChBLlqzpOBu6seMVffEPehdLCvV3J4p1fGTDWCm2USbFnBNYuSQ3q3SUjMqTJrlpklWTPGmSh9p5fr9c9AzTn8ZvLxXgG5BrFG4g_fX0f1d_AdMJohA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1461629189</pqid></control><display><type>article</type><title>Sexual dysfunction in pre-menopausal diabetic women: clinical, metabolic, psychological, cardiovascular, and neurophysiologic correlates</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Cortelazzi, Donatella ; Marconi, Annamaria ; Guazzi, Marco ; Cristina, Maurizio ; Zecchini, Barbara ; Veronelli, Annamaria ; Cattalini, Claudio ; Innocenti, Alessandro ; Bosco, Giovanna ; Pontiroli, Antonio E.</creator><creatorcontrib>Cortelazzi, Donatella ; Marconi, Annamaria ; Guazzi, Marco ; Cristina, Maurizio ; Zecchini, Barbara ; Veronelli, Annamaria ; Cattalini, Claudio ; Innocenti, Alessandro ; Bosco, Giovanna ; Pontiroli, Antonio E.</creatorcontrib><description><![CDATA[An increased prevalence of female sexual dysfunction (FSD) has been reported in women with diabetes mellitus (DM). Our aim was to evaluate correlates (psychological, cardiovascular, and neurophysiologic) of FSD in DM women without chronic diabetic complications. Female Sexual Function Index (FSFI), Beck Depression Inventory (BDI), Michigan Diabetic Neuropathy Index (DNI), and the symptoms of diabetic neuropathy (SDN) questionnaires, metabolic variables, endothelial vascular function (flow-mediated dilation, FMD), echocardiography, and electromyography were studied. 109 pre-menopausal women (18–50 years) [48 with DM (14 type 1 DM, 34 type 2 DM, duration 12.6 ± 1.91 years), and 61 healthy women] received the above questionnaires; physical activity, smoking habits, parity, BMI, waist circumference, HOMA-IR index, fibrinogen, cholesterol (total, HDL, LDL), triglycerides, HbA1c, high-sensitivity C-reactive protein, total testosterone, and estradiol were measured; echocardiography, assessment of intima-media thickness (IMT), FMD, ECG (heart rate and Qtc, indexes of sympathetic activity), and electromyography were performed. FSFI total score and score for arousal, lubrication, and orgasm domains were lower in DM women than in controls (
P
< 0.05); DM women had higher BDI, Doppler
A
wave peak velocity, DNI, and SDN score (
P
< 0.001 to
P
< 0.04). Doppler
E
wave peak velocity, peroneal, posterior tibial and sural nerves conduction velocity and amplitude were lower in diabetic women than in controls (
P
< 0.05 to
P
< 0.001). FSFI score was positively correlated with physical activity, Doppler
E
wave peak velocity, and peroneal nerve amplitude and negatively with BDI, parity, IMT, SDN, and HbA1c (
P
< 0.05 to
P
< 0.001). At stepwise regression, SDN score (negatively) and Doppler
E
wave peak velocity (positively) predicted FSFI score (
r
= 507,
P
< 0.001). In conclusion, cardiovascular and neurological impairments are associated with FSD in diabetic women. Follow-up studies are required to evaluate sexual dysfunction as a risk factor for future cardiovascular or neurological events.]]></description><identifier>ISSN: 0940-5429</identifier><identifier>EISSN: 1432-5233</identifier><identifier>DOI: 10.1007/s00592-013-0482-x</identifier><identifier>PMID: 23677545</identifier><identifier>CODEN: ACDAEZ</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adolescent ; Adult ; Cardiovascular System - physiopathology ; Depression - epidemiology ; Depression - metabolism ; Depression - physiopathology ; Diabetes ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes Mellitus, Type 1 - psychology ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - psychology ; Echocardiography ; Female ; Health risk assessment ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Neuropsychological Tests ; Original Article ; Premenopause ; Prevalence ; Sexual disorders ; Sexual Dysfunction, Physiological - epidemiology ; Sexual Dysfunction, Physiological - metabolism ; Sexual Dysfunction, Physiological - psychology ; Studies ; Surveys and Questionnaires ; Vasodilation - physiology ; Womens health ; Young Adult</subject><ispartof>Acta diabetologica, 2013-12, Vol.50 (6), p.911-917</ispartof><rights>Springer-Verlag Italia 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-9f280c1dfa651e63fbfc2c6aec9c6bfb2b1fac73eef1db052d7220372befd80e3</citedby><cites>FETCH-LOGICAL-c372t-9f280c1dfa651e63fbfc2c6aec9c6bfb2b1fac73eef1db052d7220372befd80e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00592-013-0482-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00592-013-0482-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23677545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cortelazzi, Donatella</creatorcontrib><creatorcontrib>Marconi, Annamaria</creatorcontrib><creatorcontrib>Guazzi, Marco</creatorcontrib><creatorcontrib>Cristina, Maurizio</creatorcontrib><creatorcontrib>Zecchini, Barbara</creatorcontrib><creatorcontrib>Veronelli, Annamaria</creatorcontrib><creatorcontrib>Cattalini, Claudio</creatorcontrib><creatorcontrib>Innocenti, Alessandro</creatorcontrib><creatorcontrib>Bosco, Giovanna</creatorcontrib><creatorcontrib>Pontiroli, Antonio E.</creatorcontrib><title>Sexual dysfunction in pre-menopausal diabetic women: clinical, metabolic, psychological, cardiovascular, and neurophysiologic correlates</title><title>Acta diabetologica</title><addtitle>Acta Diabetol</addtitle><addtitle>Acta Diabetol</addtitle><description><![CDATA[An increased prevalence of female sexual dysfunction (FSD) has been reported in women with diabetes mellitus (DM). Our aim was to evaluate correlates (psychological, cardiovascular, and neurophysiologic) of FSD in DM women without chronic diabetic complications. Female Sexual Function Index (FSFI), Beck Depression Inventory (BDI), Michigan Diabetic Neuropathy Index (DNI), and the symptoms of diabetic neuropathy (SDN) questionnaires, metabolic variables, endothelial vascular function (flow-mediated dilation, FMD), echocardiography, and electromyography were studied. 109 pre-menopausal women (18–50 years) [48 with DM (14 type 1 DM, 34 type 2 DM, duration 12.6 ± 1.91 years), and 61 healthy women] received the above questionnaires; physical activity, smoking habits, parity, BMI, waist circumference, HOMA-IR index, fibrinogen, cholesterol (total, HDL, LDL), triglycerides, HbA1c, high-sensitivity C-reactive protein, total testosterone, and estradiol were measured; echocardiography, assessment of intima-media thickness (IMT), FMD, ECG (heart rate and Qtc, indexes of sympathetic activity), and electromyography were performed. FSFI total score and score for arousal, lubrication, and orgasm domains were lower in DM women than in controls (
P
< 0.05); DM women had higher BDI, Doppler
A
wave peak velocity, DNI, and SDN score (
P
< 0.001 to
P
< 0.04). Doppler
E
wave peak velocity, peroneal, posterior tibial and sural nerves conduction velocity and amplitude were lower in diabetic women than in controls (
P
< 0.05 to
P
< 0.001). FSFI score was positively correlated with physical activity, Doppler
E
wave peak velocity, and peroneal nerve amplitude and negatively with BDI, parity, IMT, SDN, and HbA1c (
P
< 0.05 to
P
< 0.001). At stepwise regression, SDN score (negatively) and Doppler
E
wave peak velocity (positively) predicted FSFI score (
r
= 507,
P
< 0.001). In conclusion, cardiovascular and neurological impairments are associated with FSD in diabetic women. Follow-up studies are required to evaluate sexual dysfunction as a risk factor for future cardiovascular or neurological events.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Cardiovascular System - physiopathology</subject><subject>Depression - epidemiology</subject><subject>Depression - metabolism</subject><subject>Depression - physiopathology</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>Diabetes Mellitus, Type 1 - metabolism</subject><subject>Diabetes Mellitus, Type 1 - psychology</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - psychology</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Original Article</subject><subject>Premenopause</subject><subject>Prevalence</subject><subject>Sexual disorders</subject><subject>Sexual Dysfunction, Physiological - epidemiology</subject><subject>Sexual Dysfunction, Physiological - metabolism</subject><subject>Sexual Dysfunction, Physiological - psychology</subject><subject>Studies</subject><subject>Surveys and Questionnaires</subject><subject>Vasodilation - physiology</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>0940-5429</issn><issn>1432-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc2KFDEYRYMoTs_oA7iRgBsXHc1P_bqTwVFhwIW6Dknqy0yGVFImFe1-Ax_bNDWKCK4CuefeBA5Czxh9xSjtX2dK25ETygShzcDJ4QHasUZw0nIhHqIdHRtK2oaPZ-g85ztKGe_F8BidcdH1fdu0O_TzMxyK8ng6ZluCWV0M2AW8JCAzhLiokk-pUxpWZ_CPWG_fYONdcEb5PZ5hVTp6Z_Z4yUdzG3282RKj0uTid5VN8SrtsQoTDlBSXG6P2W0cNjEl8GqF_AQ9sspneHp_XqCvV---XH4g15_ef7x8e02M6PlKRssHathkVdcy6ITV1nDTKTCj6bTVXDOrTC8ALJs0bfnUc05rVYOdBgriAr3cdpcUvxXIq5xdNuC9ChBLlqzpOBu6seMVffEPehdLCvV3J4p1fGTDWCm2USbFnBNYuSQ3q3SUjMqTJrlpklWTPGmSh9p5fr9c9AzTn8ZvLxXgG5BrFG4g_fX0f1d_AdMJohA</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Cortelazzi, Donatella</creator><creator>Marconi, Annamaria</creator><creator>Guazzi, Marco</creator><creator>Cristina, Maurizio</creator><creator>Zecchini, Barbara</creator><creator>Veronelli, Annamaria</creator><creator>Cattalini, Claudio</creator><creator>Innocenti, Alessandro</creator><creator>Bosco, Giovanna</creator><creator>Pontiroli, Antonio E.</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20131201</creationdate><title>Sexual dysfunction in pre-menopausal diabetic women: clinical, metabolic, psychological, cardiovascular, and neurophysiologic correlates</title><author>Cortelazzi, Donatella ; Marconi, Annamaria ; Guazzi, Marco ; Cristina, Maurizio ; Zecchini, Barbara ; Veronelli, Annamaria ; Cattalini, Claudio ; Innocenti, Alessandro ; Bosco, Giovanna ; Pontiroli, Antonio E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-9f280c1dfa651e63fbfc2c6aec9c6bfb2b1fac73eef1db052d7220372befd80e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cardiovascular System - physiopathology</topic><topic>Depression - epidemiology</topic><topic>Depression - metabolism</topic><topic>Depression - physiopathology</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - epidemiology</topic><topic>Diabetes Mellitus, Type 1 - metabolism</topic><topic>Diabetes Mellitus, Type 1 - psychology</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - psychology</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Original Article</topic><topic>Premenopause</topic><topic>Prevalence</topic><topic>Sexual disorders</topic><topic>Sexual Dysfunction, Physiological - epidemiology</topic><topic>Sexual Dysfunction, Physiological - metabolism</topic><topic>Sexual Dysfunction, Physiological - psychology</topic><topic>Studies</topic><topic>Surveys and Questionnaires</topic><topic>Vasodilation - physiology</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cortelazzi, Donatella</creatorcontrib><creatorcontrib>Marconi, Annamaria</creatorcontrib><creatorcontrib>Guazzi, Marco</creatorcontrib><creatorcontrib>Cristina, Maurizio</creatorcontrib><creatorcontrib>Zecchini, Barbara</creatorcontrib><creatorcontrib>Veronelli, Annamaria</creatorcontrib><creatorcontrib>Cattalini, Claudio</creatorcontrib><creatorcontrib>Innocenti, Alessandro</creatorcontrib><creatorcontrib>Bosco, Giovanna</creatorcontrib><creatorcontrib>Pontiroli, Antonio E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Acta diabetologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cortelazzi, Donatella</au><au>Marconi, Annamaria</au><au>Guazzi, Marco</au><au>Cristina, Maurizio</au><au>Zecchini, Barbara</au><au>Veronelli, Annamaria</au><au>Cattalini, Claudio</au><au>Innocenti, Alessandro</au><au>Bosco, Giovanna</au><au>Pontiroli, Antonio E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexual dysfunction in pre-menopausal diabetic women: clinical, metabolic, psychological, cardiovascular, and neurophysiologic correlates</atitle><jtitle>Acta diabetologica</jtitle><stitle>Acta Diabetol</stitle><addtitle>Acta Diabetol</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>50</volume><issue>6</issue><spage>911</spage><epage>917</epage><pages>911-917</pages><issn>0940-5429</issn><eissn>1432-5233</eissn><coden>ACDAEZ</coden><abstract><![CDATA[An increased prevalence of female sexual dysfunction (FSD) has been reported in women with diabetes mellitus (DM). Our aim was to evaluate correlates (psychological, cardiovascular, and neurophysiologic) of FSD in DM women without chronic diabetic complications. Female Sexual Function Index (FSFI), Beck Depression Inventory (BDI), Michigan Diabetic Neuropathy Index (DNI), and the symptoms of diabetic neuropathy (SDN) questionnaires, metabolic variables, endothelial vascular function (flow-mediated dilation, FMD), echocardiography, and electromyography were studied. 109 pre-menopausal women (18–50 years) [48 with DM (14 type 1 DM, 34 type 2 DM, duration 12.6 ± 1.91 years), and 61 healthy women] received the above questionnaires; physical activity, smoking habits, parity, BMI, waist circumference, HOMA-IR index, fibrinogen, cholesterol (total, HDL, LDL), triglycerides, HbA1c, high-sensitivity C-reactive protein, total testosterone, and estradiol were measured; echocardiography, assessment of intima-media thickness (IMT), FMD, ECG (heart rate and Qtc, indexes of sympathetic activity), and electromyography were performed. FSFI total score and score for arousal, lubrication, and orgasm domains were lower in DM women than in controls (
P
< 0.05); DM women had higher BDI, Doppler
A
wave peak velocity, DNI, and SDN score (
P
< 0.001 to
P
< 0.04). Doppler
E
wave peak velocity, peroneal, posterior tibial and sural nerves conduction velocity and amplitude were lower in diabetic women than in controls (
P
< 0.05 to
P
< 0.001). FSFI score was positively correlated with physical activity, Doppler
E
wave peak velocity, and peroneal nerve amplitude and negatively with BDI, parity, IMT, SDN, and HbA1c (
P
< 0.05 to
P
< 0.001). At stepwise regression, SDN score (negatively) and Doppler
E
wave peak velocity (positively) predicted FSFI score (
r
= 507,
P
< 0.001). In conclusion, cardiovascular and neurological impairments are associated with FSD in diabetic women. Follow-up studies are required to evaluate sexual dysfunction as a risk factor for future cardiovascular or neurological events.]]></abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>23677545</pmid><doi>10.1007/s00592-013-0482-x</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Cardiovascular System - physiopathology Depression - epidemiology Depression - metabolism Depression - physiopathology Diabetes Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - psychology Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - psychology Echocardiography Female Health risk assessment Humans Internal Medicine Medicine Medicine & Public Health Metabolic Diseases Middle Aged Neuropsychological Tests Original Article Premenopause Prevalence Sexual disorders Sexual Dysfunction, Physiological - epidemiology Sexual Dysfunction, Physiological - metabolism Sexual Dysfunction, Physiological - psychology Studies Surveys and Questionnaires Vasodilation - physiology Womens health Young Adult |
| title | Sexual dysfunction in pre-menopausal diabetic women: clinical, metabolic, psychological, cardiovascular, and neurophysiologic correlates |
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