Increased number of Th22 cells and correlation with Th17 cells in peripheral blood of patients with IgA nephropathy
Abstract T-helper (Th) 22 and Th17 cells are involved in the pathogenesis of autoimmune diseases. However, the role of Th22 and correlation with Th17 cells in the pathophysiology of IgA nephropathy (IgAN) remain unknown. In our study, Th22 and Th17 cells in peripheral blood of IgAN patients, non-IgA...
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| Veröffentlicht in: | Human immunology 2013-12, Vol.74 (12), p.1586-1591 |
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| creator | Peng, Zhiguo Tian, Jun Cui, Xianquan Xian, Wanhua Sun, Huaibin Li, Engang Geng, Lina Zhang, Luwei Zhao, Peng |
| description | Abstract T-helper (Th) 22 and Th17 cells are involved in the pathogenesis of autoimmune diseases. However, the role of Th22 and correlation with Th17 cells in the pathophysiology of IgA nephropathy (IgAN) remain unknown. In our study, Th22 and Th17 cells in peripheral blood of IgAN patients, non-IgA mesangial proliferative glomerulonephritis (non-IgA MsPGN) patients, and healthy controls were measured by flow cytometry. The concentration of plasma interleukin-22 (IL-22) was examined by enzyme linked immunosorbent assay (ELISA). The results showed that Th22 cells, Th17 cells, and plasma IL-22 were significantly elevated in IgAN patients compared with non-IgA MsPGN patients and healthy controls. Th22 cells showed a positive correlation with the levels of plasma IL-22 in IgAN patients. Moreover, a significantly positive correlation between Th22 cells and Th17 in IgAN patients was observed. Furthermore, IgAN patients with proteinuria showed a higher percentage of Th22 cells than IgAN patients without proteinuria. Our data demonstrated that IgAN had increased frequencies of peripheral Th22, Th17 cells and plasma IL-22, indicating that Th22 along with Th17 cells are involved in the immune responses of IgAN. |
| doi_str_mv | 10.1016/j.humimm.2013.08.001 |
| format | Article |
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However, the role of Th22 and correlation with Th17 cells in the pathophysiology of IgA nephropathy (IgAN) remain unknown. In our study, Th22 and Th17 cells in peripheral blood of IgAN patients, non-IgA mesangial proliferative glomerulonephritis (non-IgA MsPGN) patients, and healthy controls were measured by flow cytometry. The concentration of plasma interleukin-22 (IL-22) was examined by enzyme linked immunosorbent assay (ELISA). The results showed that Th22 cells, Th17 cells, and plasma IL-22 were significantly elevated in IgAN patients compared with non-IgA MsPGN patients and healthy controls. Th22 cells showed a positive correlation with the levels of plasma IL-22 in IgAN patients. Moreover, a significantly positive correlation between Th22 cells and Th17 in IgAN patients was observed. Furthermore, IgAN patients with proteinuria showed a higher percentage of Th22 cells than IgAN patients without proteinuria. Our data demonstrated that IgAN had increased frequencies of peripheral Th22, Th17 cells and plasma IL-22, indicating that Th22 along with Th17 cells are involved in the immune responses of IgAN.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/j.humimm.2013.08.001</identifier><identifier>PMID: 23978338</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Allergy and Immunology ; CD4 Lymphocyte Count ; Female ; Glomerulonephritis, IGA - blood ; Glomerulonephritis, IGA - diagnosis ; Glomerulonephritis, IGA - immunology ; Humans ; Immunophenotyping ; Interleukin-22 ; Interleukins - blood ; Male ; Middle Aged ; Prognosis ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - metabolism ; T-Lymphocytes, Helper-Inducer - immunology ; T-Lymphocytes, Helper-Inducer - metabolism ; Th17 Cells - immunology ; Th17 Cells - metabolism ; Young Adult</subject><ispartof>Human immunology, 2013-12, Vol.74 (12), p.1586-1591</ispartof><rights>American Society for Histocompatibility and Immunogenetics</rights><rights>2013 American Society for Histocompatibility and Immunogenetics</rights><rights>Copyright © 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. 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However, the role of Th22 and correlation with Th17 cells in the pathophysiology of IgA nephropathy (IgAN) remain unknown. In our study, Th22 and Th17 cells in peripheral blood of IgAN patients, non-IgA mesangial proliferative glomerulonephritis (non-IgA MsPGN) patients, and healthy controls were measured by flow cytometry. The concentration of plasma interleukin-22 (IL-22) was examined by enzyme linked immunosorbent assay (ELISA). The results showed that Th22 cells, Th17 cells, and plasma IL-22 were significantly elevated in IgAN patients compared with non-IgA MsPGN patients and healthy controls. Th22 cells showed a positive correlation with the levels of plasma IL-22 in IgAN patients. Moreover, a significantly positive correlation between Th22 cells and Th17 in IgAN patients was observed. Furthermore, IgAN patients with proteinuria showed a higher percentage of Th22 cells than IgAN patients without proteinuria. Our data demonstrated that IgAN had increased frequencies of peripheral Th22, Th17 cells and plasma IL-22, indicating that Th22 along with Th17 cells are involved in the immune responses of IgAN.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>CD4 Lymphocyte Count</subject><subject>Female</subject><subject>Glomerulonephritis, IGA - blood</subject><subject>Glomerulonephritis, IGA - diagnosis</subject><subject>Glomerulonephritis, IGA - immunology</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Interleukin-22</subject><subject>Interleukins - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - metabolism</subject><subject>Th17 Cells - immunology</subject><subject>Th17 Cells - metabolism</subject><subject>Young Adult</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQQC0EotvCP0DIRy5ZxnY2di5IVVVgpUocKGfLcSbES2IHOynaf4-jLBy4cLLkefP1hpA3DPYMWPX-tO-X0Y3jngMTe1B7APaM7JiSdcFYVT0nO2C1KpQ61FfkOqUTAEiQ5UtyxUUtlRBqR9LR24gmYUv9MjYYaejoY885tTgMiRrfUhtixMHMLnj6y819jjN5iTtPJ4xu6jGagTZDCO1aYco0-jlt_PH7LfU49THk__78irzozJDw9eW9Id8-3j_efS4evnw63t0-FLZkci4sg9awVmJd1aKBUsrOtEqAkPzQcWlVyQ-1Qd7wTmLVdk0lSkQGvD7IGptG3JB3W90php8LplmPLq1jG49hSZqVFWeqkkJktNxQG0NKETs9RTeaeNYM9Kpbn_SmW6-6NSiddee0t5cOSzNi-zfpj98MfNgAzHs-OYw62SzGYusi2lm3wf2vw78F7OC8s2b4gWdMp7BEnx1qphPXoL-uJ18vzgQA53m334D6qBk</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Peng, Zhiguo</creator><creator>Tian, Jun</creator><creator>Cui, Xianquan</creator><creator>Xian, Wanhua</creator><creator>Sun, Huaibin</creator><creator>Li, Engang</creator><creator>Geng, Lina</creator><creator>Zhang, Luwei</creator><creator>Zhao, Peng</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131201</creationdate><title>Increased number of Th22 cells and correlation with Th17 cells in peripheral blood of patients with IgA nephropathy</title><author>Peng, Zhiguo ; Tian, Jun ; Cui, Xianquan ; Xian, Wanhua ; Sun, Huaibin ; Li, Engang ; Geng, Lina ; Zhang, Luwei ; Zhao, Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c10da1d7e9693b0477fad8303725f27c84259ae2b2f7e6dfb634ee1029579ebb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>CD4 Lymphocyte Count</topic><topic>Female</topic><topic>Glomerulonephritis, IGA - blood</topic><topic>Glomerulonephritis, IGA - diagnosis</topic><topic>Glomerulonephritis, IGA - immunology</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Interleukin-22</topic><topic>Interleukins - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - metabolism</topic><topic>Th17 Cells - immunology</topic><topic>Th17 Cells - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Zhiguo</creatorcontrib><creatorcontrib>Tian, Jun</creatorcontrib><creatorcontrib>Cui, Xianquan</creatorcontrib><creatorcontrib>Xian, Wanhua</creatorcontrib><creatorcontrib>Sun, Huaibin</creatorcontrib><creatorcontrib>Li, Engang</creatorcontrib><creatorcontrib>Geng, Lina</creatorcontrib><creatorcontrib>Zhang, Luwei</creatorcontrib><creatorcontrib>Zhao, Peng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Zhiguo</au><au>Tian, Jun</au><au>Cui, Xianquan</au><au>Xian, Wanhua</au><au>Sun, Huaibin</au><au>Li, Engang</au><au>Geng, Lina</au><au>Zhang, Luwei</au><au>Zhao, Peng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased number of Th22 cells and correlation with Th17 cells in peripheral blood of patients with IgA nephropathy</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>74</volume><issue>12</issue><spage>1586</spage><epage>1591</epage><pages>1586-1591</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><abstract>Abstract T-helper (Th) 22 and Th17 cells are involved in the pathogenesis of autoimmune diseases. However, the role of Th22 and correlation with Th17 cells in the pathophysiology of IgA nephropathy (IgAN) remain unknown. In our study, Th22 and Th17 cells in peripheral blood of IgAN patients, non-IgA mesangial proliferative glomerulonephritis (non-IgA MsPGN) patients, and healthy controls were measured by flow cytometry. The concentration of plasma interleukin-22 (IL-22) was examined by enzyme linked immunosorbent assay (ELISA). The results showed that Th22 cells, Th17 cells, and plasma IL-22 were significantly elevated in IgAN patients compared with non-IgA MsPGN patients and healthy controls. Th22 cells showed a positive correlation with the levels of plasma IL-22 in IgAN patients. Moreover, a significantly positive correlation between Th22 cells and Th17 in IgAN patients was observed. Furthermore, IgAN patients with proteinuria showed a higher percentage of Th22 cells than IgAN patients without proteinuria. Our data demonstrated that IgAN had increased frequencies of peripheral Th22, Th17 cells and plasma IL-22, indicating that Th22 along with Th17 cells are involved in the immune responses of IgAN.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23978338</pmid><doi>10.1016/j.humimm.2013.08.001</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Allergy and Immunology CD4 Lymphocyte Count Female Glomerulonephritis, IGA - blood Glomerulonephritis, IGA - diagnosis Glomerulonephritis, IGA - immunology Humans Immunophenotyping Interleukin-22 Interleukins - blood Male Middle Aged Prognosis T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Th17 Cells - immunology Th17 Cells - metabolism Young Adult |
| title | Increased number of Th22 cells and correlation with Th17 cells in peripheral blood of patients with IgA nephropathy |
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