Phase quantification of antihypertensive drugs – Chlorthalidone, Hydrochlorothiazide, Losartan and combinations, Losartan/Chlorthalidone and Losartan/Hydrochlorothiazide – by the Rietveld method
•Quantitative analysis has been realized for antihypertensive drugs and associations.•Specifically, Losartan potassium, Chlorthalidone, Hydrochlorothiazide.•The drugs have been characterized X-ray powder diffraction.•Rietveld method has been performed. The identification and quantification of crysta...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2014, Vol.88, p.152-156 |
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| creator | Reis do Carmo, Weberton Ferreira, Fabio Furlan Diniz, Renata |
| description | •Quantitative analysis has been realized for antihypertensive drugs and associations.•Specifically, Losartan potassium, Chlorthalidone, Hydrochlorothiazide.•The drugs have been characterized X-ray powder diffraction.•Rietveld method has been performed.
The identification and quantification of crystalline phases of antihypertensive drugs – Losartan potassium (LOS-K), Hydrochlorothiazide (HCTZ) and Chlorthalidone (CTD) were carried out by means of X-ray powder diffraction data and the Rietveld method. Quantitative phase analyses of Losartan potassium/Chlorthalidone (LOS-K/CTD) and Losartan potassium/Hydrochlorothiazide (LOS-K/HCTZ) combinations were also evaluated. The results indicated that for diuretics (HCTZ and CTD) only one crystalline phase was found in samples, and for LOS-K the crystal structure showed similarity between the Bragg peaks to the phase described as monoclinic and space group P21/c. After one year storage, the orthorhombic one was also observed in this sample. |
| doi_str_mv | 10.1016/j.jpba.2013.08.035 |
| format | Article |
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The identification and quantification of crystalline phases of antihypertensive drugs – Losartan potassium (LOS-K), Hydrochlorothiazide (HCTZ) and Chlorthalidone (CTD) were carried out by means of X-ray powder diffraction data and the Rietveld method. Quantitative phase analyses of Losartan potassium/Chlorthalidone (LOS-K/CTD) and Losartan potassium/Hydrochlorothiazide (LOS-K/HCTZ) combinations were also evaluated. The results indicated that for diuretics (HCTZ and CTD) only one crystalline phase was found in samples, and for LOS-K the crystal structure showed similarity between the Bragg peaks to the phase described as monoclinic and space group P21/c. After one year storage, the orthorhombic one was also observed in this sample.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2013.08.035</identifier><identifier>PMID: 24055851</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Angiotensin II Type 1 Receptor Blockers - analysis ; Antihypertensive Agents - analysis ; Chemistry, Pharmaceutical ; Chlorthalidone ; Chlorthalidone - analysis ; Crystallization ; Diuretics - chemistry ; Drug Stability ; Hydrochlorothiazide - analysis ; Hydrochlorothiazide and Rietveld method ; Losartan - analysis ; Losartan potassium ; Polymorphism ; Powders ; Temperature ; Time Factors ; X-Ray Diffraction ; X-ray diffractometry</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2014, Vol.88, p.152-156</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-446b42d023cd428c0c8453e7b20fa3b7cc003c88c0365f3f40946f7ac864abe63</citedby><cites>FETCH-LOGICAL-c356t-446b42d023cd428c0c8453e7b20fa3b7cc003c88c0365f3f40946f7ac864abe63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpba.2013.08.035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24055851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reis do Carmo, Weberton</creatorcontrib><creatorcontrib>Ferreira, Fabio Furlan</creatorcontrib><creatorcontrib>Diniz, Renata</creatorcontrib><title>Phase quantification of antihypertensive drugs – Chlorthalidone, Hydrochlorothiazide, Losartan and combinations, Losartan/Chlorthalidone and Losartan/Hydrochlorothiazide – by the Rietveld method</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>•Quantitative analysis has been realized for antihypertensive drugs and associations.•Specifically, Losartan potassium, Chlorthalidone, Hydrochlorothiazide.•The drugs have been characterized X-ray powder diffraction.•Rietveld method has been performed.
The identification and quantification of crystalline phases of antihypertensive drugs – Losartan potassium (LOS-K), Hydrochlorothiazide (HCTZ) and Chlorthalidone (CTD) were carried out by means of X-ray powder diffraction data and the Rietveld method. Quantitative phase analyses of Losartan potassium/Chlorthalidone (LOS-K/CTD) and Losartan potassium/Hydrochlorothiazide (LOS-K/HCTZ) combinations were also evaluated. The results indicated that for diuretics (HCTZ and CTD) only one crystalline phase was found in samples, and for LOS-K the crystal structure showed similarity between the Bragg peaks to the phase described as monoclinic and space group P21/c. After one year storage, the orthorhombic one was also observed in this sample.</description><subject>Angiotensin II Type 1 Receptor Blockers - analysis</subject><subject>Antihypertensive Agents - analysis</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chlorthalidone</subject><subject>Chlorthalidone - analysis</subject><subject>Crystallization</subject><subject>Diuretics - chemistry</subject><subject>Drug Stability</subject><subject>Hydrochlorothiazide - analysis</subject><subject>Hydrochlorothiazide and Rietveld method</subject><subject>Losartan - analysis</subject><subject>Losartan potassium</subject><subject>Polymorphism</subject><subject>Powders</subject><subject>Temperature</subject><subject>Time Factors</subject><subject>X-Ray Diffraction</subject><subject>X-ray diffractometry</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd2K1DAYhoMo7rh6Ax5IDj2w3fw1zYInMqyuMKCIgmchTb7aDG0zm6QD45H34D15IV6J7cy6IohHId_7fE8IL0JPKSkpofJiW253jSkZobwkqiS8uodWVNW8YFJ8vo9WpOa0qImqztCjlLaEkIpeiofojAlSVaqiK_TjfWcS4JvJjNm33prsw4hDi5d7d9hBzDAmvwfs4vQl4Z_fvuN114eYO9N7F0Z4ga8PLga7DEPuvPnq3TzchGRiNuMsctiGofHj0Z3-RBd_i47kXfYP6fHx5oBzB_iDh7yH3uEBchfcY_SgNX2CJ7fnOfr0-urj-rrYvHvzdv1qU1heyVwIIRvBHGHcOsGUJVaJikPdMNIa3tTWEsKtmgMuq5a3glwK2dbGKilMA5Kfo-cn7y6GmwlS1oNPFvrejBCmpKmQjCrJeT2j7ITaGFKK0Opd9IOJB02JXvrTW730p5f-NFF67m9eenbrn5oB3N3K78Jm4OUJgPmXew9RJ-thtOB8BJu1C_5__l-HiLPE</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Reis do Carmo, Weberton</creator><creator>Ferreira, Fabio Furlan</creator><creator>Diniz, Renata</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Phase quantification of antihypertensive drugs – Chlorthalidone, Hydrochlorothiazide, Losartan and combinations, Losartan/Chlorthalidone and Losartan/Hydrochlorothiazide – by the Rietveld method</title><author>Reis do Carmo, Weberton ; Ferreira, Fabio Furlan ; Diniz, Renata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-446b42d023cd428c0c8453e7b20fa3b7cc003c88c0365f3f40946f7ac864abe63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Angiotensin II Type 1 Receptor Blockers - analysis</topic><topic>Antihypertensive Agents - analysis</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chlorthalidone</topic><topic>Chlorthalidone - analysis</topic><topic>Crystallization</topic><topic>Diuretics - chemistry</topic><topic>Drug Stability</topic><topic>Hydrochlorothiazide - analysis</topic><topic>Hydrochlorothiazide and Rietveld method</topic><topic>Losartan - analysis</topic><topic>Losartan potassium</topic><topic>Polymorphism</topic><topic>Powders</topic><topic>Temperature</topic><topic>Time Factors</topic><topic>X-Ray Diffraction</topic><topic>X-ray diffractometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reis do Carmo, Weberton</creatorcontrib><creatorcontrib>Ferreira, Fabio Furlan</creatorcontrib><creatorcontrib>Diniz, Renata</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reis do Carmo, Weberton</au><au>Ferreira, Fabio Furlan</au><au>Diniz, Renata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phase quantification of antihypertensive drugs – Chlorthalidone, Hydrochlorothiazide, Losartan and combinations, Losartan/Chlorthalidone and Losartan/Hydrochlorothiazide – by the Rietveld method</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2014</date><risdate>2014</risdate><volume>88</volume><spage>152</spage><epage>156</epage><pages>152-156</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><abstract>•Quantitative analysis has been realized for antihypertensive drugs and associations.•Specifically, Losartan potassium, Chlorthalidone, Hydrochlorothiazide.•The drugs have been characterized X-ray powder diffraction.•Rietveld method has been performed.
The identification and quantification of crystalline phases of antihypertensive drugs – Losartan potassium (LOS-K), Hydrochlorothiazide (HCTZ) and Chlorthalidone (CTD) were carried out by means of X-ray powder diffraction data and the Rietveld method. Quantitative phase analyses of Losartan potassium/Chlorthalidone (LOS-K/CTD) and Losartan potassium/Hydrochlorothiazide (LOS-K/HCTZ) combinations were also evaluated. The results indicated that for diuretics (HCTZ and CTD) only one crystalline phase was found in samples, and for LOS-K the crystal structure showed similarity between the Bragg peaks to the phase described as monoclinic and space group P21/c. After one year storage, the orthorhombic one was also observed in this sample.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>24055851</pmid><doi>10.1016/j.jpba.2013.08.035</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical and biomedical analysis, 2014, Vol.88, p.152-156 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Angiotensin II Type 1 Receptor Blockers - analysis Antihypertensive Agents - analysis Chemistry, Pharmaceutical Chlorthalidone Chlorthalidone - analysis Crystallization Diuretics - chemistry Drug Stability Hydrochlorothiazide - analysis Hydrochlorothiazide and Rietveld method Losartan - analysis Losartan potassium Polymorphism Powders Temperature Time Factors X-Ray Diffraction X-ray diffractometry |
| title | Phase quantification of antihypertensive drugs – Chlorthalidone, Hydrochlorothiazide, Losartan and combinations, Losartan/Chlorthalidone and Losartan/Hydrochlorothiazide – by the Rietveld method |
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