Frailty and cognitive impairment—A review of the evidence and causal mechanisms

Highlights • Frailty may be a marker for future cognitive impairment. • Executive function is the cognitive domain most strongly associated with frailty. • Frailty and cognition interact within a cycle of age-associated decline. • AD pathology, cardiovascular risk, depression, and others, are potent...

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Veröffentlicht in:	Ageing research reviews 2013-09, Vol.12 (4), p.840-851
Hauptverfasser:	Robertson, Deirdre A, Savva, George M, Kenny, Rose Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer Disease - psychology Biological and medical sciences Cognition Disorders - diagnosis Cognition Disorders - epidemiology Cognition Disorders - psychology Cross-Sectional Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - diagnosis Dementia - epidemiology Dementia - psychology Development. Metamorphosis. Moult. Ageing Frail Elderly - psychology Fundamental and applied biological sciences. Psychology Humans Internal Medicine Longitudinal Studies Medical sciences Miscellaneous Neurology Public health. Hygiene Public health. Hygiene-occupational medicine Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Beschreibung
Zusammenfassung:	Highlights • Frailty may be a marker for future cognitive impairment. • Executive function is the cognitive domain most strongly associated with frailty. • Frailty and cognition interact within a cycle of age-associated decline. • AD pathology, cardiovascular risk, depression, and others, are potential mediators. • Our new model outlines the interactions between these hypothesised causal mechanisms.
ISSN:	1568-1637 1872-9649
DOI:	10.1016/j.arr.2013.06.004