Down-Regulation of PTEN Expression Modulated by Dysregulated miR-21 Contributes to the Progression of Esophageal Cancer

Background and Aim miR-21, a putative tumor oncomiR, is a frequently overexpressed miRNA in a variety of tumors. Because it targets tumor-suppressor genes it has been linked to tumor progression. In this study we investigated the role of miR-21 in esophageal squamous cell carcinoma (ESCC), and its p...

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Veröffentlicht in:	Digestive diseases and sciences 2013-12, Vol.58 (12), p.3483-3493
Hauptverfasser:	Li, Pei, Mao, Wei-Min, Zheng, Zhi-Guo, Dong, Zi-Ming, Ling, Zhi-Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Biochemistry Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cells China - epidemiology Development and progression Disease Progression Down-Regulation Esophageal cancer Esophageal Neoplasms - metabolism Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophagus - pathology Female Gastroenterology Genetic aspects Genetic research Hepatology Humans Male Medicine Medicine & Public Health MicroRNA MicroRNAs - physiology Middle Aged Oncology Original Article PTEN Phosphohydrolase - antagonists & inhibitors PTEN Phosphohydrolase - biosynthesis Squamous cell carcinoma Transplant Surgery Tumors Up-Regulation
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