Relationship between insulin resistance, dyslipidaemia and positive symptom in Chinese antipsychotic-naive first-episode patients with schizophrenia
Abstract Controversial results concerning insulin resistance and lipid metabolism have been reported in antipsychotic-naive first-episode psychosis (AN-FEP) patients with schizophrenia of different countries. We aimed at determining whether schizophrenia-related psychopathology was associated with i...
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| Veröffentlicht in: | Psychiatry research 2013-12, Vol.210 (3), p.825-829 |
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| creator | Chen, Song Broqueres-You, Dong Yang, Guigang Wang, Zhiren Li, Yanli Wang, Ning Zhang, Xiangyang Yang, Fude Tan, Yunlong |
| description | Abstract Controversial results concerning insulin resistance and lipid metabolism have been reported in antipsychotic-naive first-episode psychosis (AN-FEP) patients with schizophrenia of different countries. We aimed at determining whether schizophrenia-related psychopathology was associated with insulin resistance and/or dyslipidaemia in Chinese patients with AN-FEP schizophrenia. A cross-sectional study was performed in Chinese patients newly diagnosed with schizophrenia ( n = 49, antipsychotic-naïve or antipsychotic medications< 2 weeks) and healthy volunteers ( n = 30). The serum levels of insulin and triglyceride levels as well as homeostasis model of assessment-insulin resistance (HOMA-IR) index were significantly increased in AN-FEP patients, when compared with healthy volunteers. The gender difference had a significant impact on the insulin resistance and dyslipidaemia in these AN-FEP subjects. Multiple linear regression analysis demonstrated that the severity of positive symptoms of schizophrenia was negatively related to insulin resistance. No difference of serum glucose level, total cholesterol content, body mass index (BMI) and smoking status was detected between patients with schizophrenia and healthy controls. In conclusion, Chinese AN-FEP patients were more prone to insulin resistance and dyslipidaemia as compared to the healthy population, which is negatively correlated to positive symptoms. The results may contribute to the understanding of the relationship between the glucose/lipidaemia metabolic dysfunction and the psychopathology in patients with schizophrenia. |
| doi_str_mv | 10.1016/j.psychres.2013.08.056 |
| format | Article |
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We aimed at determining whether schizophrenia-related psychopathology was associated with insulin resistance and/or dyslipidaemia in Chinese patients with AN-FEP schizophrenia. A cross-sectional study was performed in Chinese patients newly diagnosed with schizophrenia ( n = 49, antipsychotic-naïve or antipsychotic medications< 2 weeks) and healthy volunteers ( n = 30). The serum levels of insulin and triglyceride levels as well as homeostasis model of assessment-insulin resistance (HOMA-IR) index were significantly increased in AN-FEP patients, when compared with healthy volunteers. The gender difference had a significant impact on the insulin resistance and dyslipidaemia in these AN-FEP subjects. Multiple linear regression analysis demonstrated that the severity of positive symptoms of schizophrenia was negatively related to insulin resistance. No difference of serum glucose level, total cholesterol content, body mass index (BMI) and smoking status was detected between patients with schizophrenia and healthy controls. In conclusion, Chinese AN-FEP patients were more prone to insulin resistance and dyslipidaemia as compared to the healthy population, which is negatively correlated to positive symptoms. The results may contribute to the understanding of the relationship between the glucose/lipidaemia metabolic dysfunction and the psychopathology in patients with schizophrenia.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2013.08.056</identifier><identifier>PMID: 24113122</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Antipsychotic Agents - therapeutic use ; Antipsychotic-naive first-episode psychosis schizophrenia ; Asian Continental Ancestry Group ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Mass Index ; Case-Control Studies ; China - epidemiology ; Cholesterol - blood ; Cross-Sectional Studies ; Dyslipidaemia ; Dyslipidemias - ethnology ; Female ; Glucose - metabolism ; Glucose Tolerance Test ; Humans ; Insulin - metabolism ; Insulin resistance ; Insulin Resistance - ethnology ; Lipid Metabolism - drug effects ; Male ; Medical sciences ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology ; Psychopathology. Psychiatry ; Psychoses ; Psychotic Disorders - drug therapy ; Regression Analysis ; Schizophrenia ; Schizophrenia - blood ; Schizophrenia - ethnology ; Schizophrenia - pathology ; Young Adult</subject><ispartof>Psychiatry research, 2013-12, Vol.210 (3), p.825-829</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2013 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-918da8a19a92edd8ddb4a0e9ecf6e8d625a2407d394e5d6e9b7533523d7d61f93</citedby><cites>FETCH-LOGICAL-c453t-918da8a19a92edd8ddb4a0e9ecf6e8d625a2407d394e5d6e9b7533523d7d61f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165178113005179$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28028090$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24113122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Song</creatorcontrib><creatorcontrib>Broqueres-You, Dong</creatorcontrib><creatorcontrib>Yang, Guigang</creatorcontrib><creatorcontrib>Wang, Zhiren</creatorcontrib><creatorcontrib>Li, Yanli</creatorcontrib><creatorcontrib>Wang, Ning</creatorcontrib><creatorcontrib>Zhang, Xiangyang</creatorcontrib><creatorcontrib>Yang, Fude</creatorcontrib><creatorcontrib>Tan, Yunlong</creatorcontrib><title>Relationship between insulin resistance, dyslipidaemia and positive symptom in Chinese antipsychotic-naive first-episode patients with schizophrenia</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract Controversial results concerning insulin resistance and lipid metabolism have been reported in antipsychotic-naive first-episode psychosis (AN-FEP) patients with schizophrenia of different countries. We aimed at determining whether schizophrenia-related psychopathology was associated with insulin resistance and/or dyslipidaemia in Chinese patients with AN-FEP schizophrenia. A cross-sectional study was performed in Chinese patients newly diagnosed with schizophrenia ( n = 49, antipsychotic-naïve or antipsychotic medications< 2 weeks) and healthy volunteers ( n = 30). The serum levels of insulin and triglyceride levels as well as homeostasis model of assessment-insulin resistance (HOMA-IR) index were significantly increased in AN-FEP patients, when compared with healthy volunteers. The gender difference had a significant impact on the insulin resistance and dyslipidaemia in these AN-FEP subjects. Multiple linear regression analysis demonstrated that the severity of positive symptoms of schizophrenia was negatively related to insulin resistance. No difference of serum glucose level, total cholesterol content, body mass index (BMI) and smoking status was detected between patients with schizophrenia and healthy controls. In conclusion, Chinese AN-FEP patients were more prone to insulin resistance and dyslipidaemia as compared to the healthy population, which is negatively correlated to positive symptoms. The results may contribute to the understanding of the relationship between the glucose/lipidaemia metabolic dysfunction and the psychopathology in patients with schizophrenia.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Antipsychotic-naive first-episode psychosis schizophrenia</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Cholesterol - blood</subject><subject>Cross-Sectional Studies</subject><subject>Dyslipidaemia</subject><subject>Dyslipidemias - ethnology</subject><subject>Female</subject><subject>Glucose - metabolism</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - ethnology</subject><subject>Lipid Metabolism - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Psychotic Disorders - drug therapy</subject><subject>Regression Analysis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - ethnology</subject><subject>Schizophrenia - pathology</subject><subject>Young Adult</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFktuKFDEQhhtR3HH1FZbcCF7YYw59yo0ogydYEDxch0xSzdTYnbRdmV3a5_CBzTizCt4IgQTqq0P-v4riSvC14KJ5sV9PtLjdDLSWXKg179a8bu4VK9G1smyFVPeLVQbrUrSduCgeEe0551Jo_bC4kJUQSki5Kn5-gsEmjIF2OLEtpFuAwDDQYcDAcnmkZIOD58wvNOCE3sKIltng2RQJE94Ao2WcUhxzGtvsMABBjif8PWFM6Mpgj1iPM6USJqTogU25LYRE7BbTjpHb4Y845Q8FtI-LB70dCJ6c78vi69s3Xzbvy-uP7z5sXl-XrqpVKrXovO2s0FZL8L7zfltZDhpc30DnG1lbWfHWK11B7RvQ27ZWqpbKt74RvVaXxbNT3WmO3w9AyYxIDobBBogHMqJqRNcJzlVGmxPq5kg0Q2-mGUc7L0Zwc3TE7M2dI-boiOGdyY7kxKtzj8N2BP8n7c6CDDw9A5acHfo5y430l-t4Pppn7tWJg6zIDcJsyGUBHXicwSXjI_5_lpf_lHDZZcxdv8ECtI-HOWS9jTAkDTefj_tzXB-hOM8PrX4B1wjHXg</recordid><startdate>20131230</startdate><enddate>20131230</enddate><creator>Chen, Song</creator><creator>Broqueres-You, Dong</creator><creator>Yang, Guigang</creator><creator>Wang, Zhiren</creator><creator>Li, Yanli</creator><creator>Wang, Ning</creator><creator>Zhang, Xiangyang</creator><creator>Yang, Fude</creator><creator>Tan, Yunlong</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131230</creationdate><title>Relationship between insulin resistance, dyslipidaemia and positive symptom in Chinese antipsychotic-naive first-episode patients with schizophrenia</title><author>Chen, Song ; Broqueres-You, Dong ; Yang, Guigang ; Wang, Zhiren ; Li, Yanli ; Wang, Ning ; Zhang, Xiangyang ; Yang, Fude ; Tan, Yunlong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-918da8a19a92edd8ddb4a0e9ecf6e8d625a2407d394e5d6e9b7533523d7d61f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Antipsychotic-naive first-episode psychosis schizophrenia</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Cholesterol - blood</topic><topic>Cross-Sectional Studies</topic><topic>Dyslipidaemia</topic><topic>Dyslipidemias - ethnology</topic><topic>Female</topic><topic>Glucose - metabolism</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - ethnology</topic><topic>Lipid Metabolism - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Psychotic Disorders - drug therapy</topic><topic>Regression Analysis</topic><topic>Schizophrenia</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenia - ethnology</topic><topic>Schizophrenia - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Song</creatorcontrib><creatorcontrib>Broqueres-You, Dong</creatorcontrib><creatorcontrib>Yang, Guigang</creatorcontrib><creatorcontrib>Wang, Zhiren</creatorcontrib><creatorcontrib>Li, Yanli</creatorcontrib><creatorcontrib>Wang, Ning</creatorcontrib><creatorcontrib>Zhang, Xiangyang</creatorcontrib><creatorcontrib>Yang, Fude</creatorcontrib><creatorcontrib>Tan, Yunlong</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Song</au><au>Broqueres-You, Dong</au><au>Yang, Guigang</au><au>Wang, Zhiren</au><au>Li, Yanli</au><au>Wang, Ning</au><au>Zhang, Xiangyang</au><au>Yang, Fude</au><au>Tan, Yunlong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between insulin resistance, dyslipidaemia and positive symptom in Chinese antipsychotic-naive first-episode patients with schizophrenia</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2013-12-30</date><risdate>2013</risdate><volume>210</volume><issue>3</issue><spage>825</spage><epage>829</epage><pages>825-829</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Abstract Controversial results concerning insulin resistance and lipid metabolism have been reported in antipsychotic-naive first-episode psychosis (AN-FEP) patients with schizophrenia of different countries. We aimed at determining whether schizophrenia-related psychopathology was associated with insulin resistance and/or dyslipidaemia in Chinese patients with AN-FEP schizophrenia. A cross-sectional study was performed in Chinese patients newly diagnosed with schizophrenia ( n = 49, antipsychotic-naïve or antipsychotic medications< 2 weeks) and healthy volunteers ( n = 30). The serum levels of insulin and triglyceride levels as well as homeostasis model of assessment-insulin resistance (HOMA-IR) index were significantly increased in AN-FEP patients, when compared with healthy volunteers. The gender difference had a significant impact on the insulin resistance and dyslipidaemia in these AN-FEP subjects. Multiple linear regression analysis demonstrated that the severity of positive symptoms of schizophrenia was negatively related to insulin resistance. No difference of serum glucose level, total cholesterol content, body mass index (BMI) and smoking status was detected between patients with schizophrenia and healthy controls. In conclusion, Chinese AN-FEP patients were more prone to insulin resistance and dyslipidaemia as compared to the healthy population, which is negatively correlated to positive symptoms. The results may contribute to the understanding of the relationship between the glucose/lipidaemia metabolic dysfunction and the psychopathology in patients with schizophrenia.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>24113122</pmid><doi>10.1016/j.psychres.2013.08.056</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Antipsychotic Agents - therapeutic use Antipsychotic-naive first-episode psychosis schizophrenia Asian Continental Ancestry Group Biological and medical sciences Blood Glucose - metabolism Body Mass Index Case-Control Studies China - epidemiology Cholesterol - blood Cross-Sectional Studies Dyslipidaemia Dyslipidemias - ethnology Female Glucose - metabolism Glucose Tolerance Test Humans Insulin - metabolism Insulin resistance Insulin Resistance - ethnology Lipid Metabolism - drug effects Male Medical sciences Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology Psychopathology. Psychiatry Psychoses Psychotic Disorders - drug therapy Regression Analysis Schizophrenia Schizophrenia - blood Schizophrenia - ethnology Schizophrenia - pathology Young Adult |
| title | Relationship between insulin resistance, dyslipidaemia and positive symptom in Chinese antipsychotic-naive first-episode patients with schizophrenia |
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