Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: A randomized clinical trial
Abstract Mental health is an important medical issue in perinatal care, and there is increasing evidence that insomnia during pregnancy is associated with postpartum depression (PPD). Therefore, the present study evaluated the effect of insomnia treatment during the third trimester of pregnancy on P...
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| Veröffentlicht in: | Psychiatry research 2013-12, Vol.210 (3), p.901-905 |
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| creator | Khazaie, Habibolah Ghadami, Mohammad Rasoul Knight, David C Emamian, Farnoosh Tahmasian, Masoud |
| description | Abstract Mental health is an important medical issue in perinatal care, and there is increasing evidence that insomnia during pregnancy is associated with postpartum depression (PPD). Therefore, the present study evaluated the effect of insomnia treatment during the third trimester of pregnancy on PPD symptoms. Fifty-four pregnant women with insomnia were randomly assigned to trazodone, diphenhydramine, or placebo treatment. Sleep quality was measured by actigraphy at baseline, and after 2 and 6 weeks of treatment. In addition, depression was assessed 2 and 6 weeks after delivery. Trazodone and diphenhydramine improved sleep profile compared to placebo after 6 weeks of treatment. Further, depressive symptoms were reduced 2 and 6 weeks after delivery in trazodone and diphenhydramine groups compared to placebo. No differences in depressive symptoms were observed between the trazodone and diphenhydramine groups. These findings indicate that insomnia treatment with trazodone or diphenhydramine during the third trimester of pregnancy may prevent PPD. |
| doi_str_mv | 10.1016/j.psychres.2013.08.017 |
| format | Article |
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Therefore, the present study evaluated the effect of insomnia treatment during the third trimester of pregnancy on PPD symptoms. Fifty-four pregnant women with insomnia were randomly assigned to trazodone, diphenhydramine, or placebo treatment. Sleep quality was measured by actigraphy at baseline, and after 2 and 6 weeks of treatment. In addition, depression was assessed 2 and 6 weeks after delivery. Trazodone and diphenhydramine improved sleep profile compared to placebo after 6 weeks of treatment. Further, depressive symptoms were reduced 2 and 6 weeks after delivery in trazodone and diphenhydramine groups compared to placebo. No differences in depressive symptoms were observed between the trazodone and diphenhydramine groups. These findings indicate that insomnia treatment with trazodone or diphenhydramine during the third trimester of pregnancy may prevent PPD.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2013.08.017</identifier><identifier>PMID: 23993464</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Actigraphy ; Adult ; Adult and adolescent clinical studies ; Antidepressive Agents, Second-Generation - therapeutic use ; Biological and medical sciences ; Depression ; Depression - diagnosis ; Depression - psychology ; Depression, Postpartum - prevention & control ; Diphenhydramine ; Diphenhydramine - therapeutic use ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Female ; Humans ; Insomnia ; Medical sciences ; Mood disorders ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Pharmacology. Drug treatments ; Postpartum depression ; Pregnancy ; Pregnancy Complications - psychology ; Pregnancy Trimester, Third ; Psychiatric Status Rating Scales ; Psychiatry ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Severity of Illness Index ; Sleep - drug effects ; Sleep disorders ; Sleep Initiation and Maintenance Disorders - drug therapy ; Sleep Initiation and Maintenance Disorders - etiology ; Sleep Wake Disorders - drug therapy ; Sleep Wake Disorders - psychology ; Trazodone ; Trazodone - administration & dosage ; Trazodone - adverse effects ; Trazodone - therapeutic use ; Treatment Outcome</subject><ispartof>Psychiatry research, 2013-12, Vol.210 (3), p.901-905</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2013 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-c7939a9cc627c6e7715dc5447a2893b98c9ea5cdc29f1d897b582c0c80c03f423</citedby><cites>FETCH-LOGICAL-c519t-c7939a9cc627c6e7715dc5447a2893b98c9ea5cdc29f1d897b582c0c80c03f423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165178113004770$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28028102$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23993464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khazaie, Habibolah</creatorcontrib><creatorcontrib>Ghadami, Mohammad Rasoul</creatorcontrib><creatorcontrib>Knight, David C</creatorcontrib><creatorcontrib>Emamian, Farnoosh</creatorcontrib><creatorcontrib>Tahmasian, Masoud</creatorcontrib><title>Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: A randomized clinical trial</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract Mental health is an important medical issue in perinatal care, and there is increasing evidence that insomnia during pregnancy is associated with postpartum depression (PPD). Therefore, the present study evaluated the effect of insomnia treatment during the third trimester of pregnancy on PPD symptoms. Fifty-four pregnant women with insomnia were randomly assigned to trazodone, diphenhydramine, or placebo treatment. Sleep quality was measured by actigraphy at baseline, and after 2 and 6 weeks of treatment. In addition, depression was assessed 2 and 6 weeks after delivery. Trazodone and diphenhydramine improved sleep profile compared to placebo after 6 weeks of treatment. Further, depressive symptoms were reduced 2 and 6 weeks after delivery in trazodone and diphenhydramine groups compared to placebo. No differences in depressive symptoms were observed between the trazodone and diphenhydramine groups. These findings indicate that insomnia treatment with trazodone or diphenhydramine during the third trimester of pregnancy may prevent PPD.</description><subject>Actigraphy</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antidepressive Agents, Second-Generation - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Depression</subject><subject>Depression - diagnosis</subject><subject>Depression - psychology</subject><subject>Depression, Postpartum - prevention & control</subject><subject>Diphenhydramine</subject><subject>Diphenhydramine - therapeutic use</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Female</subject><subject>Humans</subject><subject>Insomnia</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Postpartum depression</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - psychology</subject><subject>Pregnancy Trimester, Third</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Severity of Illness Index</subject><subject>Sleep - drug effects</subject><subject>Sleep disorders</subject><subject>Sleep Initiation and Maintenance Disorders - drug therapy</subject><subject>Sleep Initiation and Maintenance Disorders - etiology</subject><subject>Sleep Wake Disorders - drug therapy</subject><subject>Sleep Wake Disorders - psychology</subject><subject>Trazodone</subject><subject>Trazodone - administration & dosage</subject><subject>Trazodone - adverse effects</subject><subject>Trazodone - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuLFDEQgBtR3HH1Lyy5CF56TNKPJB7EZfGxsOBBPYdMdbWbsTtpU93C7K83zcwoePEQAslXr48qiivBt4KL9vV-O9EB7hPSVnJRbbnecqEeFRuhlSyVkNXjYpPBphRKi4viGdGecy6FMU-LC1kZU9VtvSkebgPFMXjH5oRuHjHMzAc232M-PnX52Y9IMyYWezYl_B5cgANL2C2AxKZI8-TSvIysw_xN5GNgdBinOY70hl2z5EIXR_-AHYPBBw9uWJO64XnxpHcD4YvTfVl8-_D-682n8u7zx9ub67sSGmHmEpSpjDMArVTQolKi6aCpa-WkNtXOaDDoGuhAml502qhdoyVw0Bx41deyuixeHfNOKf5c8ix29AQ4DC5gXMiKuhVacy3bjLZHFFIkStjbKY_v0sEKblfvdm_P3u3q3XJts_cceHWqsexG7P6EnUVn4OUJcJQN9NkKePrLaS614Guz744cZiO_PCZL4DEAdj4hzLaL_v-9vP0nxdn7Dzwg7eOSQvZthSVpuf2ybsm6JKLivFaKV78BGfW8Tw</recordid><startdate>20131230</startdate><enddate>20131230</enddate><creator>Khazaie, Habibolah</creator><creator>Ghadami, Mohammad Rasoul</creator><creator>Knight, David C</creator><creator>Emamian, Farnoosh</creator><creator>Tahmasian, Masoud</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131230</creationdate><title>Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: A randomized clinical trial</title><author>Khazaie, Habibolah ; Ghadami, Mohammad Rasoul ; Knight, David C ; Emamian, Farnoosh ; Tahmasian, Masoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-c7939a9cc627c6e7715dc5447a2893b98c9ea5cdc29f1d897b582c0c80c03f423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Actigraphy</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antidepressive Agents, Second-Generation - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Depression - diagnosis</topic><topic>Depression - psychology</topic><topic>Depression, Postpartum - prevention & control</topic><topic>Diphenhydramine</topic><topic>Diphenhydramine - therapeutic use</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>Female</topic><topic>Humans</topic><topic>Insomnia</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Postpartum depression</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - psychology</topic><topic>Pregnancy Trimester, Third</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Severity of Illness Index</topic><topic>Sleep - drug effects</topic><topic>Sleep disorders</topic><topic>Sleep Initiation and Maintenance Disorders - drug therapy</topic><topic>Sleep Initiation and Maintenance Disorders - etiology</topic><topic>Sleep Wake Disorders - drug therapy</topic><topic>Sleep Wake Disorders - psychology</topic><topic>Trazodone</topic><topic>Trazodone - administration & dosage</topic><topic>Trazodone - adverse effects</topic><topic>Trazodone - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khazaie, Habibolah</creatorcontrib><creatorcontrib>Ghadami, Mohammad Rasoul</creatorcontrib><creatorcontrib>Knight, David C</creatorcontrib><creatorcontrib>Emamian, Farnoosh</creatorcontrib><creatorcontrib>Tahmasian, Masoud</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khazaie, Habibolah</au><au>Ghadami, Mohammad Rasoul</au><au>Knight, David C</au><au>Emamian, Farnoosh</au><au>Tahmasian, Masoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: A randomized clinical trial</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2013-12-30</date><risdate>2013</risdate><volume>210</volume><issue>3</issue><spage>901</spage><epage>905</epage><pages>901-905</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Abstract Mental health is an important medical issue in perinatal care, and there is increasing evidence that insomnia during pregnancy is associated with postpartum depression (PPD). Therefore, the present study evaluated the effect of insomnia treatment during the third trimester of pregnancy on PPD symptoms. Fifty-four pregnant women with insomnia were randomly assigned to trazodone, diphenhydramine, or placebo treatment. Sleep quality was measured by actigraphy at baseline, and after 2 and 6 weeks of treatment. In addition, depression was assessed 2 and 6 weeks after delivery. Trazodone and diphenhydramine improved sleep profile compared to placebo after 6 weeks of treatment. Further, depressive symptoms were reduced 2 and 6 weeks after delivery in trazodone and diphenhydramine groups compared to placebo. No differences in depressive symptoms were observed between the trazodone and diphenhydramine groups. These findings indicate that insomnia treatment with trazodone or diphenhydramine during the third trimester of pregnancy may prevent PPD.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>23993464</pmid><doi>10.1016/j.psychres.2013.08.017</doi><tpages>5</tpages></addata></record> |
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| subjects | Actigraphy Adult Adult and adolescent clinical studies Antidepressive Agents, Second-Generation - therapeutic use Biological and medical sciences Depression Depression - diagnosis Depression - psychology Depression, Postpartum - prevention & control Diphenhydramine Diphenhydramine - therapeutic use Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Female Humans Insomnia Medical sciences Mood disorders Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacology. Drug treatments Postpartum depression Pregnancy Pregnancy Complications - psychology Pregnancy Trimester, Third Psychiatric Status Rating Scales Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Severity of Illness Index Sleep - drug effects Sleep disorders Sleep Initiation and Maintenance Disorders - drug therapy Sleep Initiation and Maintenance Disorders - etiology Sleep Wake Disorders - drug therapy Sleep Wake Disorders - psychology Trazodone Trazodone - administration & dosage Trazodone - adverse effects Trazodone - therapeutic use Treatment Outcome |
| title | Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: A randomized clinical trial |
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