Dual lipidation of the brain-specific Cdc42 isoform regulates its functional properties

Cdc42 (cell division cycle 42) is a member of the Rho GTPase family which regulates a variety of cellular activities by controlling actin cytoskeleton and gene expression. Cdc42 is expressed in the form of two splice variants. The canonical Cdc42 isoform is prenylated (Cdc42-prenyl), whereas the bra...

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Veröffentlicht in:	Biochemical journal 2013-12, Vol.456 (3), p.311-322
Hauptverfasser:	Wirth, Alexander, Chen-Wacker, Chen, Wu, Yao-Wen, Gorinski, Nataliya, Filippov, Mikhail A, Pandey, Ghanshyam, Ponimaskin, Evgeni
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cdc42 GTP-Binding Protein - genetics cdc42 GTP-Binding Protein - metabolism Cell Line, Tumor Cerebellum - cytology Cerebellum - metabolism Cysteine - genetics Cysteine - metabolism Dendrites - genetics Dendrites - metabolism Hippocampus - cytology Hippocampus - metabolism Humans Isoenzymes - genetics Isoenzymes - metabolism Lipoylation - physiology Mice Organ Specificity - physiology Protein Prenylation - physiology Pseudopodia - genetics Pseudopodia - metabolism Transcription, Genetic - physiology
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