Isoxanthohumol modulates angiogenesis and inflammation via vascular endothelial growth factor receptor, tumor necrosis factor alpha and nuclear factor kappa B pathways

Angiogenesis and inflammation are becoming distinguished players in the pathogenesis of many heterogeneous diseases, such as diabetes, cardiovascular disease, and cancer. Therefore, it is crucial to study new compounds that are able to modulate these events. Isoxanthohumol (IXN) is a polyphenol with...

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Veröffentlicht in:	BioFactors (Oxford) 2013-11, Vol.39 (6), p.608-622
Hauptverfasser:	Negrão, Rita, Duarte, Delfim, Costa, Raquel, Soares, Raquel
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt angiogenesis Angiogenesis Modulating Agents - pharmacology Angiopoietins - metabolism Animals Cell Movement - drug effects Cells, Cultured Down-Regulation - drug effects Drug Evaluation, Preclinical Erk Extracellular Signal-Regulated MAP Kinases - metabolism HASMC Human Umbilical Vein Endothelial Cells Humans HUVEC Inflammation Mediators - pharmacology isoxanthohumol Mice Mice, Inbred C57BL Neovascularization, Physiologic - drug effects NF-kappa B - metabolism NFκB Proto-Oncogene Proteins c-akt - metabolism Receptor, TIE-2 - metabolism retinal angiogenesis Retinal Vessels - drug effects Retinal Vessels - physiology Signal Transduction TNF-α Tumor Necrosis Factor-alpha - physiology Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGFR2 Xanthones - pharmacology
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