Potential of Chilean Native Corn (Zea mays L.) Accessions as Natural Sources of Phenolic Antioxidants and in Vitro Bioactivity for Hyperglycemia and Hypertension Management
Thirty-three Chilean corn accessions were screened for the first time regarding their phenolic profiles, total phenolic contents (TPC), antioxidant capacity (DPPH and ABTS), and in vitro inhibition against key enzymes relevant for hyperglycemia (α-amylase and α-glucosidase) and hypertension (angiote...
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Veröffentlicht in: | Journal of agricultural and food chemistry 2013-11, Vol.61 (46), p.10995-11007 |
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creator | González-Muñoz, Adrian Quesille-Villalobos, Ana Maria Fuentealba, Claudia Shetty, Kalidas Gálvez Ranilla, Lena |
description | Thirty-three Chilean corn accessions were screened for the first time regarding their phenolic profiles, total phenolic contents (TPC), antioxidant capacity (DPPH and ABTS), and in vitro inhibition against key enzymes relevant for hyperglycemia (α-amylase and α-glucosidase) and hypertension (angiotensin I-converting enzyme, ACE-I) in both free and cell wall-bound fractions. TPC varied from 132.2 to 262.5 mg of gallic acid equivalents/100g dry weight (DW), and around 88% of TPC and antioxidant capacity were found in the bound form. Vanillin, vanillic, protocatechuic, ferulic, and p-coumaric acids were detected by HPLC in free fractions, whereas ferulic and p-coumaric acids were found in the bound form. Pisankalla accession (red kernel) had the highest ferulic acid content (269.5 mg/100g DW). No α-amylase and ACE-I inhibition were found; however, all free fractions inhibited α-glucosidase (10.8–72.5%). Principal component analysis revealed that darker samples (free fraction) showed higher TPC and antioxidant capacity, while α-glucosidase inhibition was related to yellow-colored samples. |
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Accessions as Natural Sources of Phenolic Antioxidants and in Vitro Bioactivity for Hyperglycemia and Hypertension Management</title><source>MEDLINE</source><source>ACS Publications</source><creator>González-Muñoz, Adrian ; Quesille-Villalobos, Ana Maria ; Fuentealba, Claudia ; Shetty, Kalidas ; Gálvez Ranilla, Lena</creator><creatorcontrib>González-Muñoz, Adrian ; Quesille-Villalobos, Ana Maria ; Fuentealba, Claudia ; Shetty, Kalidas ; Gálvez Ranilla, Lena</creatorcontrib><description>Thirty-three Chilean corn accessions were screened for the first time regarding their phenolic profiles, total phenolic contents (TPC), antioxidant capacity (DPPH and ABTS), and in vitro inhibition against key enzymes relevant for hyperglycemia (α-amylase and α-glucosidase) and hypertension (angiotensin I-converting enzyme, ACE-I) in both free and cell wall-bound fractions. TPC varied from 132.2 to 262.5 mg of gallic acid equivalents/100g dry weight (DW), and around 88% of TPC and antioxidant capacity were found in the bound form. Vanillin, vanillic, protocatechuic, ferulic, and p-coumaric acids were detected by HPLC in free fractions, whereas ferulic and p-coumaric acids were found in the bound form. Pisankalla accession (red kernel) had the highest ferulic acid content (269.5 mg/100g DW). No α-amylase and ACE-I inhibition were found; however, all free fractions inhibited α-glucosidase (10.8–72.5%). Principal component analysis revealed that darker samples (free fraction) showed higher TPC and antioxidant capacity, while α-glucosidase inhibition was related to yellow-colored samples.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf403237p</identifier><identifier>PMID: 24156632</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>alpha-amylase ; alpha-Amylases - antagonists & inhibitors ; alpha-glucosidase ; Angiotensin-Converting Enzyme Inhibitors - chemistry ; Antihypertensive Agents - chemistry ; antioxidant activity ; antioxidants ; Antioxidants - chemistry ; Biological and medical sciences ; Chile ; corn ; Enzyme Inhibitors - chemistry ; ferulic acid ; Fundamental and applied biological sciences. Psychology ; gallic acid ; Glycoside Hydrolase Inhibitors ; high performance liquid chromatography ; hyperglycemia ; hypertension ; Hypoglycemic Agents - chemistry ; peptidyl-dipeptidase A ; Phenols - chemistry ; Plant Extracts - administration & dosage ; principal component analysis ; seeds ; vanillin ; Zea mays ; Zea mays - chemistry</subject><ispartof>Journal of agricultural and food chemistry, 2013-11, Vol.61 (46), p.10995-11007</ispartof><rights>Copyright © 2013 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a369t-9db767cf3f8cf661a1dbce6096ec51c07df7c85cfad0fa6d61e1e83a5d01a8703</citedby><cites>FETCH-LOGICAL-a369t-9db767cf3f8cf661a1dbce6096ec51c07df7c85cfad0fa6d61e1e83a5d01a8703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf403237p$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf403237p$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2756,27067,27915,27916,56729,56779</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27979182$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24156632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González-Muñoz, Adrian</creatorcontrib><creatorcontrib>Quesille-Villalobos, Ana Maria</creatorcontrib><creatorcontrib>Fuentealba, Claudia</creatorcontrib><creatorcontrib>Shetty, Kalidas</creatorcontrib><creatorcontrib>Gálvez Ranilla, Lena</creatorcontrib><title>Potential of Chilean Native Corn (Zea mays L.) Accessions as Natural Sources of Phenolic Antioxidants and in Vitro Bioactivity for Hyperglycemia and Hypertension Management</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Thirty-three Chilean corn accessions were screened for the first time regarding their phenolic profiles, total phenolic contents (TPC), antioxidant capacity (DPPH and ABTS), and in vitro inhibition against key enzymes relevant for hyperglycemia (α-amylase and α-glucosidase) and hypertension (angiotensin I-converting enzyme, ACE-I) in both free and cell wall-bound fractions. TPC varied from 132.2 to 262.5 mg of gallic acid equivalents/100g dry weight (DW), and around 88% of TPC and antioxidant capacity were found in the bound form. Vanillin, vanillic, protocatechuic, ferulic, and p-coumaric acids were detected by HPLC in free fractions, whereas ferulic and p-coumaric acids were found in the bound form. Pisankalla accession (red kernel) had the highest ferulic acid content (269.5 mg/100g DW). No α-amylase and ACE-I inhibition were found; however, all free fractions inhibited α-glucosidase (10.8–72.5%). Principal component analysis revealed that darker samples (free fraction) showed higher TPC and antioxidant capacity, while α-glucosidase inhibition was related to yellow-colored samples.</description><subject>alpha-amylase</subject><subject>alpha-Amylases - antagonists & inhibitors</subject><subject>alpha-glucosidase</subject><subject>Angiotensin-Converting Enzyme Inhibitors - chemistry</subject><subject>Antihypertensive Agents - chemistry</subject><subject>antioxidant activity</subject><subject>antioxidants</subject><subject>Antioxidants - chemistry</subject><subject>Biological and medical sciences</subject><subject>Chile</subject><subject>corn</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>ferulic acid</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gallic acid</subject><subject>Glycoside Hydrolase Inhibitors</subject><subject>high performance liquid chromatography</subject><subject>hyperglycemia</subject><subject>hypertension</subject><subject>Hypoglycemic Agents - chemistry</subject><subject>peptidyl-dipeptidase A</subject><subject>Phenols - chemistry</subject><subject>Plant Extracts - administration & dosage</subject><subject>principal component analysis</subject><subject>seeds</subject><subject>vanillin</subject><subject>Zea mays</subject><subject>Zea mays - chemistry</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0cFu1DAQBmALgehSOPAC4AtSe0jxxImdHJcVUKQFKpVy4BLNOvbWq8Re7ASRd-IhcbpLe-Fkafz5n5GHkJfALoDl8HZnCsZzLvePyALKnGUlQPWYLFi6zKpSwAl5FuOOMVaVkj0lJ3kBpRA8X5A_V37QbrDYUW_o6tZ2Gh39goP9penKB0fPfmikPU6Rri_O6VIpHaP1LlKMsxtDenrtx5Dqc8TVrXa-s4ouU6r_bVt0Q7KupdbR73YInr6zHlVqYIeJGh_o5bTXYdtNSvcW7-hdJc01N6Kf0eFW92nK5-SJwS7qF8fzlNx8eP9tdZmtv378tFquM-SiHrK63UghleGmUkYIQGg3SgtWC61KUEy2RqqqVAZbZlC0AjToimPZMsBKMn5Kzg65--B_jjoOTW-j0l2HTvsxNlAI4AUAlImeH6gKPsagTbMPtscwNcCaeTnN_XKSfXWMHTe9bu_lv20k8OYIMCrsTECnbHxwspY1VLN7fXAGfYPbkMzNdc6gYAxkUUv-kIQqNru0HZf-6z8j_QUVOa7l</recordid><startdate>20131120</startdate><enddate>20131120</enddate><creator>González-Muñoz, Adrian</creator><creator>Quesille-Villalobos, Ana Maria</creator><creator>Fuentealba, Claudia</creator><creator>Shetty, Kalidas</creator><creator>Gálvez Ranilla, Lena</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131120</creationdate><title>Potential of Chilean Native Corn (Zea mays L.) Accessions as Natural Sources of Phenolic Antioxidants and in Vitro Bioactivity for Hyperglycemia and Hypertension Management</title><author>González-Muñoz, Adrian ; Quesille-Villalobos, Ana Maria ; Fuentealba, Claudia ; Shetty, Kalidas ; Gálvez Ranilla, Lena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a369t-9db767cf3f8cf661a1dbce6096ec51c07df7c85cfad0fa6d61e1e83a5d01a8703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>alpha-amylase</topic><topic>alpha-Amylases - antagonists & inhibitors</topic><topic>alpha-glucosidase</topic><topic>Angiotensin-Converting Enzyme Inhibitors - chemistry</topic><topic>Antihypertensive Agents - chemistry</topic><topic>antioxidant activity</topic><topic>antioxidants</topic><topic>Antioxidants - chemistry</topic><topic>Biological and medical sciences</topic><topic>Chile</topic><topic>corn</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>ferulic acid</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gallic acid</topic><topic>Glycoside Hydrolase Inhibitors</topic><topic>high performance liquid chromatography</topic><topic>hyperglycemia</topic><topic>hypertension</topic><topic>Hypoglycemic Agents - chemistry</topic><topic>peptidyl-dipeptidase A</topic><topic>Phenols - chemistry</topic><topic>Plant Extracts - administration & dosage</topic><topic>principal component analysis</topic><topic>seeds</topic><topic>vanillin</topic><topic>Zea mays</topic><topic>Zea mays - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González-Muñoz, Adrian</creatorcontrib><creatorcontrib>Quesille-Villalobos, Ana Maria</creatorcontrib><creatorcontrib>Fuentealba, Claudia</creatorcontrib><creatorcontrib>Shetty, Kalidas</creatorcontrib><creatorcontrib>Gálvez Ranilla, Lena</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González-Muñoz, Adrian</au><au>Quesille-Villalobos, Ana Maria</au><au>Fuentealba, Claudia</au><au>Shetty, Kalidas</au><au>Gálvez Ranilla, Lena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential of Chilean Native Corn (Zea mays L.) Accessions as Natural Sources of Phenolic Antioxidants and in Vitro Bioactivity for Hyperglycemia and Hypertension Management</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2013-11-20</date><risdate>2013</risdate><volume>61</volume><issue>46</issue><spage>10995</spage><epage>11007</epage><pages>10995-11007</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Thirty-three Chilean corn accessions were screened for the first time regarding their phenolic profiles, total phenolic contents (TPC), antioxidant capacity (DPPH and ABTS), and in vitro inhibition against key enzymes relevant for hyperglycemia (α-amylase and α-glucosidase) and hypertension (angiotensin I-converting enzyme, ACE-I) in both free and cell wall-bound fractions. TPC varied from 132.2 to 262.5 mg of gallic acid equivalents/100g dry weight (DW), and around 88% of TPC and antioxidant capacity were found in the bound form. Vanillin, vanillic, protocatechuic, ferulic, and p-coumaric acids were detected by HPLC in free fractions, whereas ferulic and p-coumaric acids were found in the bound form. Pisankalla accession (red kernel) had the highest ferulic acid content (269.5 mg/100g DW). No α-amylase and ACE-I inhibition were found; however, all free fractions inhibited α-glucosidase (10.8–72.5%). Principal component analysis revealed that darker samples (free fraction) showed higher TPC and antioxidant capacity, while α-glucosidase inhibition was related to yellow-colored samples.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>24156632</pmid><doi>10.1021/jf403237p</doi><tpages>13</tpages></addata></record> |
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subjects | alpha-amylase alpha-Amylases - antagonists & inhibitors alpha-glucosidase Angiotensin-Converting Enzyme Inhibitors - chemistry Antihypertensive Agents - chemistry antioxidant activity antioxidants Antioxidants - chemistry Biological and medical sciences Chile corn Enzyme Inhibitors - chemistry ferulic acid Fundamental and applied biological sciences. Psychology gallic acid Glycoside Hydrolase Inhibitors high performance liquid chromatography hyperglycemia hypertension Hypoglycemic Agents - chemistry peptidyl-dipeptidase A Phenols - chemistry Plant Extracts - administration & dosage principal component analysis seeds vanillin Zea mays Zea mays - chemistry |
title | Potential of Chilean Native Corn (Zea mays L.) Accessions as Natural Sources of Phenolic Antioxidants and in Vitro Bioactivity for Hyperglycemia and Hypertension Management |
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