Identification of epitopes within integrin β4 for binding of auto-antibodies in ocular cicatricial and mucous membrane pemphigoid: preliminary report

To identify the epitopes on human β4 integrin to which the sera of patients with ocular cicatricial pemphigoid (OCP) and mucous membrane pemphigoid (MMP) without ocular involvement bind. Fragments of the intracellular domain of the β4 molecule were cloned, expressed, purified and peptides were synth...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2013-11, Vol.54 (12), p.7707-7716
Hauptverfasser:	Rashid, Khwaja Aftab, Foster, C Stephen, Ahmed, A Razzaque
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Autoantibodies - blood Autoantigens - immunology Binding Sites, Antibody Blotting, Western Cross Reactions Electrophoresis, Polyacrylamide Gel Epitopes - immunology Fluorescent Antibody Technique, Direct Humans Integrin beta4 - immunology Mice Mice, Inbred BALB C Microscopy, Confocal Pemphigoid, Benign Mucous Membrane - immunology Peptide Fragments - immunology Rabbits
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