Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D

Lymphangiogenesis is an important physiological response to inflammatory insult, acting to limit inflammation. Macrophages, dendritic cells, and lymphocytes are known to drive lymphangiogenesis. In this study, we show that neutrophils recruited to sites of inflammation can also coordinate lymphangio...

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Veröffentlicht in:	Blood 2013-11, Vol.122 (22), p.3666-3677
Hauptverfasser:	Tan, Kar Wai, Chong, Shu Zhen, Wong, Fiona H.S., Evrard, Maximilien, Tan, Sandra Min-Li, Keeble, Jo, Kemeny, D.M., Ng, Lai Guan, Abastado, Jean-Pierre, Angeli, Véronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - immunology Dermatitis - etiology Dermatitis - metabolism Dermatitis - pathology Female Glucuronidase - metabolism Inflammation - etiology Inflammation - metabolism Inflammation - pathology Lymphangiogenesis - immunology Lymphangiogenesis - physiology Matrix Metalloproteinase 9 - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Neutrophils - immunology Neutrophils - pathology Neutrophils - physiology Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor D - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism
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