Adenocarcinoma of the anal canal - a systematic review
Aim The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in the management of anal adenocarcinoma. Method A systematic review of the literature was performed for studies in the English language publishe...
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| Veröffentlicht in: | Colorectal disease 2013-12, Vol.15 (12), p.1481-1488 |
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| container_title | Colorectal disease |
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| creator | Anwar, S. Welbourn, H. Hill, J. Sebag-Montefiore, D. |
| description | Aim
The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in the management of anal adenocarcinoma.
Method
A systematic review of the literature was performed for studies in the English language published between 1950 and 2011. All those that focused on the management of anal adenocarcinoma were considered for inclusion.
Results
Sixteen retrospective observational studies were identified; no randomized trials were found. Most of the studies contained small numbers of patients due to the rarity of anal adenocarcinoma. Treatment included local excision), radiotherapy, chemotherapy, chemoradiotherapy and abdominoperineal excision. Most studies concluded that a multimodality approach, combining radical surgical resection with neoadjuvant/adjuvant chemoradiotherapy was the optimal management strategy.
Conclusion
The prognosis of anal adenocarcinoma is poor, and there is little information on the optimal management. The relevant studies indicate that a combination of radical surgical resection and pre‐ or postoperative chemoradiotherapy offers the best chance of survival. |
| doi_str_mv | 10.1111/codi.12325 |
| format | Article |
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The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in the management of anal adenocarcinoma.
Method
A systematic review of the literature was performed for studies in the English language published between 1950 and 2011. All those that focused on the management of anal adenocarcinoma were considered for inclusion.
Results
Sixteen retrospective observational studies were identified; no randomized trials were found. Most of the studies contained small numbers of patients due to the rarity of anal adenocarcinoma. Treatment included local excision), radiotherapy, chemotherapy, chemoradiotherapy and abdominoperineal excision. Most studies concluded that a multimodality approach, combining radical surgical resection with neoadjuvant/adjuvant chemoradiotherapy was the optimal management strategy.
Conclusion
The prognosis of anal adenocarcinoma is poor, and there is little information on the optimal management. The relevant studies indicate that a combination of radical surgical resection and pre‐ or postoperative chemoradiotherapy offers the best chance of survival.</description><identifier>ISSN: 1462-8910</identifier><identifier>EISSN: 1463-1318</identifier><identifier>DOI: 10.1111/codi.12325</identifier><identifier>PMID: 23809885</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>abdominoperineal resection ; adenocarcinoma ; Adenocarcinoma - therapy ; Anal ; Anal Canal - surgery ; Anus Neoplasms - therapy ; chemo radiotherapy ; Chemoradiotherapy, Adjuvant - methods ; Chemotherapy, Adjuvant ; Humans ; Neoadjuvant Therapy - methods ; Neoplasm Recurrence, Local ; Prognosis ; Radiotherapy, Adjuvant ; Treatment Outcome</subject><ispartof>Colorectal disease, 2013-12, Vol.15 (12), p.1481-1488</ispartof><rights>2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland</rights><rights>2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4335-876c2d6e6cb2b4de4c809feb02b2ab39549a8b51ff7e967255ba8135104a3bd53</citedby><cites>FETCH-LOGICAL-c4335-876c2d6e6cb2b4de4c809feb02b2ab39549a8b51ff7e967255ba8135104a3bd53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcodi.12325$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcodi.12325$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23809885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anwar, S.</creatorcontrib><creatorcontrib>Welbourn, H.</creatorcontrib><creatorcontrib>Hill, J.</creatorcontrib><creatorcontrib>Sebag-Montefiore, D.</creatorcontrib><title>Adenocarcinoma of the anal canal - a systematic review</title><title>Colorectal disease</title><addtitle>Colorectal Dis</addtitle><description>Aim
The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in the management of anal adenocarcinoma.
Method
A systematic review of the literature was performed for studies in the English language published between 1950 and 2011. All those that focused on the management of anal adenocarcinoma were considered for inclusion.
Results
Sixteen retrospective observational studies were identified; no randomized trials were found. Most of the studies contained small numbers of patients due to the rarity of anal adenocarcinoma. Treatment included local excision), radiotherapy, chemotherapy, chemoradiotherapy and abdominoperineal excision. Most studies concluded that a multimodality approach, combining radical surgical resection with neoadjuvant/adjuvant chemoradiotherapy was the optimal management strategy.
Conclusion
The prognosis of anal adenocarcinoma is poor, and there is little information on the optimal management. The relevant studies indicate that a combination of radical surgical resection and pre‐ or postoperative chemoradiotherapy offers the best chance of survival.</description><subject>abdominoperineal resection</subject><subject>adenocarcinoma</subject><subject>Adenocarcinoma - therapy</subject><subject>Anal</subject><subject>Anal Canal - surgery</subject><subject>Anus Neoplasms - therapy</subject><subject>chemo radiotherapy</subject><subject>Chemoradiotherapy, Adjuvant - methods</subject><subject>Chemotherapy, Adjuvant</subject><subject>Humans</subject><subject>Neoadjuvant Therapy - methods</subject><subject>Neoplasm Recurrence, Local</subject><subject>Prognosis</subject><subject>Radiotherapy, Adjuvant</subject><subject>Treatment Outcome</subject><issn>1462-8910</issn><issn>1463-1318</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPAjEYRRujEUQ3_gAzS2My2Mf0MUsCgiREYoK6bNpOJ1bngS2I_HsHRljaRdvFuffLdwC4RrCPmnNv6sz1ESaYnoAuShiJEUHidP_HsUgR7ICLED4gRIwjcQ46mAiYCkG7gA0yW9VGeeOqulRRnUerdxupShWR2d9xpKKwDStbqpUzkbffzm4uwVmuimCv_t4eeBk_LIaP8Ww-mQ4Hs9gkhNBYcGZwxiwzGusks4lp5uZWQ6yx0iSlSaqEpijPuU0Zx5RqJRChCCaK6IySHrhte5e-_lrbsJKlC8YWhapsvQ6y2RARknKRNuhdixpfh-BtLpfelcpvJYJy50nuPMm9pwa--etd69JmR_QgpgFQC2xcYbf_VMnhfDQ9lMZtxjW2fo4Z5T8l44RT-fY0kclovHjm-FVS8gsYfYAD</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Anwar, S.</creator><creator>Welbourn, H.</creator><creator>Hill, J.</creator><creator>Sebag-Montefiore, D.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201312</creationdate><title>Adenocarcinoma of the anal canal - a systematic review</title><author>Anwar, S. ; Welbourn, H. ; Hill, J. ; Sebag-Montefiore, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4335-876c2d6e6cb2b4de4c809feb02b2ab39549a8b51ff7e967255ba8135104a3bd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>abdominoperineal resection</topic><topic>adenocarcinoma</topic><topic>Adenocarcinoma - therapy</topic><topic>Anal</topic><topic>Anal Canal - surgery</topic><topic>Anus Neoplasms - therapy</topic><topic>chemo radiotherapy</topic><topic>Chemoradiotherapy, Adjuvant - methods</topic><topic>Chemotherapy, Adjuvant</topic><topic>Humans</topic><topic>Neoadjuvant Therapy - methods</topic><topic>Neoplasm Recurrence, Local</topic><topic>Prognosis</topic><topic>Radiotherapy, Adjuvant</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anwar, S.</creatorcontrib><creatorcontrib>Welbourn, H.</creatorcontrib><creatorcontrib>Hill, J.</creatorcontrib><creatorcontrib>Sebag-Montefiore, D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anwar, S.</au><au>Welbourn, H.</au><au>Hill, J.</au><au>Sebag-Montefiore, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adenocarcinoma of the anal canal - a systematic review</atitle><jtitle>Colorectal disease</jtitle><addtitle>Colorectal Dis</addtitle><date>2013-12</date><risdate>2013</risdate><volume>15</volume><issue>12</issue><spage>1481</spage><epage>1488</epage><pages>1481-1488</pages><issn>1462-8910</issn><eissn>1463-1318</eissn><abstract>Aim
The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in the management of anal adenocarcinoma.
Method
A systematic review of the literature was performed for studies in the English language published between 1950 and 2011. All those that focused on the management of anal adenocarcinoma were considered for inclusion.
Results
Sixteen retrospective observational studies were identified; no randomized trials were found. Most of the studies contained small numbers of patients due to the rarity of anal adenocarcinoma. Treatment included local excision), radiotherapy, chemotherapy, chemoradiotherapy and abdominoperineal excision. Most studies concluded that a multimodality approach, combining radical surgical resection with neoadjuvant/adjuvant chemoradiotherapy was the optimal management strategy.
Conclusion
The prognosis of anal adenocarcinoma is poor, and there is little information on the optimal management. The relevant studies indicate that a combination of radical surgical resection and pre‐ or postoperative chemoradiotherapy offers the best chance of survival.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23809885</pmid><doi>10.1111/codi.12325</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1462-8910 |
| ispartof | Colorectal disease, 2013-12, Vol.15 (12), p.1481-1488 |
| issn | 1462-8910 1463-1318 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | abdominoperineal resection adenocarcinoma Adenocarcinoma - therapy Anal Anal Canal - surgery Anus Neoplasms - therapy chemo radiotherapy Chemoradiotherapy, Adjuvant - methods Chemotherapy, Adjuvant Humans Neoadjuvant Therapy - methods Neoplasm Recurrence, Local Prognosis Radiotherapy, Adjuvant Treatment Outcome |
| title | Adenocarcinoma of the anal canal - a systematic review |
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