Prevelance of hepatitis D co-enfection in children with hepatitis B infection: cross-sectional analyses from Western Turkey
Effective hepatitis B virus control has warranted a decline in hepatitis B virus prevalence over the world with a relevant reduction in hepatitis B virus-associated delta hepatitis. However, despite the dramatic decline in hepatitis D virus infection rate, no further decrease was recorded after 2000...
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| Veröffentlicht in: | The Turkish journal of gastroenterology 2013, Vol.24 (4), p.345-348 |
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| container_title | The Turkish journal of gastroenterology |
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| creator | Özgenç, Funda Ecevit, Çiğdem Ömür Erdemir, Gülin Sertöz, Rüçhan Yağcı, Raşit Vural |
| description | Effective hepatitis B virus control has warranted a decline in hepatitis B virus prevalence over the world with a relevant reduction in hepatitis B virus-associated delta hepatitis. However, despite the dramatic decline in hepatitis D virus infection rate, no further decrease was recorded after 2000. This cross-sectional study aims to investigate: I- The prevalence of hepatitis D virus co-infection in children with hepatitis B virus infection in Western Turkey; II- The influence of neonatal hepatitis B virus vaccination on hepatitis D virus co-infection rate; and III- The impact of co-infection on prognosis of liver disease.
Serological markers of hepatitis B virus and hepatitis D virus infections were determined by ELISA in patients with chronic hepatitis during immune tolerance, immunoactive, HBeAg-negative chronic, and inactive carrier state. Delta co-infection rate was evaluated in two groups, children born before and after the national neonatal mass vaccination has started (before and after 2000). Viral load, serum alanine aminotransferase, and histological grade were evaluated in co-infected cases.
Overall hepatitis delta virus infection rate was 1,76% (3/170); two patients with eAg-negative chronic hepatitis B and one patient in the immunoactive phase were infected with hepatitis D virus. Mean fibrosis score of hepatitis D virus -infected cases and hepatitis B virus -infected counterparts were 4±1,7 and 1,3±1, respectively (p: 0,006). Hepatitis D virus infection was detected in 2 out of 158 children born before and in 1 of 12 born after the neonatal vaccination program. Hepatitis B e-antibody was detected in two patients with delta co-infection (11 and 6 years old), and all mothers of delta hepatitis cases were chronically hepatitis B virus-infected.
Delta hepatitis is rare among hepatitis B virus-infected children in the Western region of Turkey. Despite the success of the national vaccination program, delta hepatitis is not a vanishing disease and it has a grave prognosis due to development of early cirrhosis. |
| doi_str_mv | 10.4318/tjg.2013.0681 |
| format | Article |
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Serological markers of hepatitis B virus and hepatitis D virus infections were determined by ELISA in patients with chronic hepatitis during immune tolerance, immunoactive, HBeAg-negative chronic, and inactive carrier state. Delta co-infection rate was evaluated in two groups, children born before and after the national neonatal mass vaccination has started (before and after 2000). Viral load, serum alanine aminotransferase, and histological grade were evaluated in co-infected cases.
Overall hepatitis delta virus infection rate was 1,76% (3/170); two patients with eAg-negative chronic hepatitis B and one patient in the immunoactive phase were infected with hepatitis D virus. Mean fibrosis score of hepatitis D virus -infected cases and hepatitis B virus -infected counterparts were 4±1,7 and 1,3±1, respectively (p: 0,006). Hepatitis D virus infection was detected in 2 out of 158 children born before and in 1 of 12 born after the neonatal vaccination program. Hepatitis B e-antibody was detected in two patients with delta co-infection (11 and 6 years old), and all mothers of delta hepatitis cases were chronically hepatitis B virus-infected.
Delta hepatitis is rare among hepatitis B virus-infected children in the Western region of Turkey. Despite the success of the national vaccination program, delta hepatitis is not a vanishing disease and it has a grave prognosis due to development of early cirrhosis.</description><identifier>ISSN: 1300-4948</identifier><identifier>EISSN: 2148-5607</identifier><identifier>DOI: 10.4318/tjg.2013.0681</identifier><identifier>PMID: 24254267</identifier><language>eng</language><publisher>Turkey</publisher><subject>Adolescent ; Alanine Transaminase - blood ; Child ; Coinfection - epidemiology ; Cross-Sectional Studies ; Hepatitis B Antibodies - blood ; Hepatitis B Vaccines ; Hepatitis B, Chronic - epidemiology ; Hepatitis B, Chronic - virology ; Hepatitis D - epidemiology ; Hepatitis D - virology ; Humans ; Infant ; Infant, Newborn ; Liver Cirrhosis - epidemiology ; Longitudinal Studies ; Prevalence ; Prognosis ; Risk Factors ; Seroepidemiologic Studies ; Turkey - epidemiology ; Viral Load</subject><ispartof>The Turkish journal of gastroenterology, 2013, Vol.24 (4), p.345-348</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c293t-67db3afafa29d445c1da04edadbf952fdf7d29522160bb527c9ef1689dba9c233</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27928,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24254267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Özgenç, Funda</creatorcontrib><creatorcontrib>Ecevit, Çiğdem Ömür</creatorcontrib><creatorcontrib>Erdemir, Gülin</creatorcontrib><creatorcontrib>Sertöz, Rüçhan</creatorcontrib><creatorcontrib>Yağcı, Raşit Vural</creatorcontrib><title>Prevelance of hepatitis D co-enfection in children with hepatitis B infection: cross-sectional analyses from Western Turkey</title><title>The Turkish journal of gastroenterology</title><addtitle>Turk J Gastroenterol</addtitle><description>Effective hepatitis B virus control has warranted a decline in hepatitis B virus prevalence over the world with a relevant reduction in hepatitis B virus-associated delta hepatitis. However, despite the dramatic decline in hepatitis D virus infection rate, no further decrease was recorded after 2000. This cross-sectional study aims to investigate: I- The prevalence of hepatitis D virus co-infection in children with hepatitis B virus infection in Western Turkey; II- The influence of neonatal hepatitis B virus vaccination on hepatitis D virus co-infection rate; and III- The impact of co-infection on prognosis of liver disease.
Serological markers of hepatitis B virus and hepatitis D virus infections were determined by ELISA in patients with chronic hepatitis during immune tolerance, immunoactive, HBeAg-negative chronic, and inactive carrier state. Delta co-infection rate was evaluated in two groups, children born before and after the national neonatal mass vaccination has started (before and after 2000). Viral load, serum alanine aminotransferase, and histological grade were evaluated in co-infected cases.
Overall hepatitis delta virus infection rate was 1,76% (3/170); two patients with eAg-negative chronic hepatitis B and one patient in the immunoactive phase were infected with hepatitis D virus. Mean fibrosis score of hepatitis D virus -infected cases and hepatitis B virus -infected counterparts were 4±1,7 and 1,3±1, respectively (p: 0,006). Hepatitis D virus infection was detected in 2 out of 158 children born before and in 1 of 12 born after the neonatal vaccination program. Hepatitis B e-antibody was detected in two patients with delta co-infection (11 and 6 years old), and all mothers of delta hepatitis cases were chronically hepatitis B virus-infected.
Delta hepatitis is rare among hepatitis B virus-infected children in the Western region of Turkey. Despite the success of the national vaccination program, delta hepatitis is not a vanishing disease and it has a grave prognosis due to development of early cirrhosis.</description><subject>Adolescent</subject><subject>Alanine Transaminase - blood</subject><subject>Child</subject><subject>Coinfection - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Hepatitis B Antibodies - blood</subject><subject>Hepatitis B Vaccines</subject><subject>Hepatitis B, Chronic - epidemiology</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Hepatitis D - epidemiology</subject><subject>Hepatitis D - virology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Liver Cirrhosis - epidemiology</subject><subject>Longitudinal Studies</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Seroepidemiologic Studies</subject><subject>Turkey - epidemiology</subject><subject>Viral Load</subject><issn>1300-4948</issn><issn>2148-5607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM9LwzAUx4Mobk6PXiVHL5351bT1pvMnCHqYeAxp8uI6u3YmrTL8583cFHmQl5APX977IHRMyVhwmp9189cxI5SPiczpDhoyKvIklSTbRUPKCUlEIfIBOghhTgjPqWT7aMAESwWT2RB9PXn4gFo3BnDr8AyWuqu6KuArbNoEGgemq9oGVw02s6q2Hhr8WXWzf-Rl_Nxi59j4NoQkbJ66xjoeqwABO98u8AuEDnyDp71_g9Uh2nO6DnC07SP0fHM9ndwlD4-395OLh8SwgneJzGzJtYvFCitEaqjVRIDVtnRFypx1mWXxwqgkZZmyzBTgqMwLW-rCMM5H6HSTu_Ttex9HUIsqGKjj1tD2QVEhKedZTrOIJhv0Zw8PTi19tdB-pShRa98q-lZr32rtO_In2-i-XID9o38F82_MFn6Q</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Özgenç, Funda</creator><creator>Ecevit, Çiğdem Ömür</creator><creator>Erdemir, Gülin</creator><creator>Sertöz, Rüçhan</creator><creator>Yağcı, Raşit Vural</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Prevelance of hepatitis D co-enfection in children with hepatitis B infection: cross-sectional analyses from Western Turkey</title><author>Özgenç, Funda ; Ecevit, Çiğdem Ömür ; Erdemir, Gülin ; Sertöz, Rüçhan ; Yağcı, Raşit Vural</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-67db3afafa29d445c1da04edadbf952fdf7d29522160bb527c9ef1689dba9c233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Alanine Transaminase - blood</topic><topic>Child</topic><topic>Coinfection - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Hepatitis B Antibodies - blood</topic><topic>Hepatitis B Vaccines</topic><topic>Hepatitis B, Chronic - epidemiology</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Hepatitis D - epidemiology</topic><topic>Hepatitis D - virology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Liver Cirrhosis - epidemiology</topic><topic>Longitudinal Studies</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Seroepidemiologic Studies</topic><topic>Turkey - epidemiology</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Özgenç, Funda</creatorcontrib><creatorcontrib>Ecevit, Çiğdem Ömür</creatorcontrib><creatorcontrib>Erdemir, Gülin</creatorcontrib><creatorcontrib>Sertöz, Rüçhan</creatorcontrib><creatorcontrib>Yağcı, Raşit Vural</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Turkish journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özgenç, Funda</au><au>Ecevit, Çiğdem Ömür</au><au>Erdemir, Gülin</au><au>Sertöz, Rüçhan</au><au>Yağcı, Raşit Vural</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevelance of hepatitis D co-enfection in children with hepatitis B infection: cross-sectional analyses from Western Turkey</atitle><jtitle>The Turkish journal of gastroenterology</jtitle><addtitle>Turk J Gastroenterol</addtitle><date>2013</date><risdate>2013</risdate><volume>24</volume><issue>4</issue><spage>345</spage><epage>348</epage><pages>345-348</pages><issn>1300-4948</issn><eissn>2148-5607</eissn><abstract>Effective hepatitis B virus control has warranted a decline in hepatitis B virus prevalence over the world with a relevant reduction in hepatitis B virus-associated delta hepatitis. However, despite the dramatic decline in hepatitis D virus infection rate, no further decrease was recorded after 2000. This cross-sectional study aims to investigate: I- The prevalence of hepatitis D virus co-infection in children with hepatitis B virus infection in Western Turkey; II- The influence of neonatal hepatitis B virus vaccination on hepatitis D virus co-infection rate; and III- The impact of co-infection on prognosis of liver disease.
Serological markers of hepatitis B virus and hepatitis D virus infections were determined by ELISA in patients with chronic hepatitis during immune tolerance, immunoactive, HBeAg-negative chronic, and inactive carrier state. Delta co-infection rate was evaluated in two groups, children born before and after the national neonatal mass vaccination has started (before and after 2000). Viral load, serum alanine aminotransferase, and histological grade were evaluated in co-infected cases.
Overall hepatitis delta virus infection rate was 1,76% (3/170); two patients with eAg-negative chronic hepatitis B and one patient in the immunoactive phase were infected with hepatitis D virus. Mean fibrosis score of hepatitis D virus -infected cases and hepatitis B virus -infected counterparts were 4±1,7 and 1,3±1, respectively (p: 0,006). Hepatitis D virus infection was detected in 2 out of 158 children born before and in 1 of 12 born after the neonatal vaccination program. Hepatitis B e-antibody was detected in two patients with delta co-infection (11 and 6 years old), and all mothers of delta hepatitis cases were chronically hepatitis B virus-infected.
Delta hepatitis is rare among hepatitis B virus-infected children in the Western region of Turkey. Despite the success of the national vaccination program, delta hepatitis is not a vanishing disease and it has a grave prognosis due to development of early cirrhosis.</abstract><cop>Turkey</cop><pmid>24254267</pmid><doi>10.4318/tjg.2013.0681</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Turkish journal of gastroenterology, 2013, Vol.24 (4), p.345-348 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Alanine Transaminase - blood Child Coinfection - epidemiology Cross-Sectional Studies Hepatitis B Antibodies - blood Hepatitis B Vaccines Hepatitis B, Chronic - epidemiology Hepatitis B, Chronic - virology Hepatitis D - epidemiology Hepatitis D - virology Humans Infant Infant, Newborn Liver Cirrhosis - epidemiology Longitudinal Studies Prevalence Prognosis Risk Factors Seroepidemiologic Studies Turkey - epidemiology Viral Load |
| title | Prevelance of hepatitis D co-enfection in children with hepatitis B infection: cross-sectional analyses from Western Turkey |
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