Testicular toxicity of N-methyltetrazolethiol cephalosporin analogs in the juvenile rat
The testicular toxicity of 10 antibiotics was evaluated in juvenile rats. Three of the antibiotics, cefbuperazone, cefamandole, and cefoperazone, contain the N-methyltetrazolethiol group as the 3-substituent; ampicillin, cefazolin, cefotaxime, cephalothin, cefoxitin, piperacillin, and ceforanide do...
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| Veröffentlicht in: | Fundamental and applied toxicology 1987-02, Vol.8 (2), p.280-289 |
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| container_title | Fundamental and applied toxicology |
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| creator | Comereski, C.R. Bregman, C.L. Buroker, R.A. |
| description | The testicular toxicity of 10 antibiotics was evaluated in juvenile rats. Three of the antibiotics, cefbuperazone, cefamandole, and cefoperazone, contain the
N-methyltetrazolethiol group as the 3-substituent; ampicillin, cefazolin, cefotaxime, cephalothin, cefoxitin, piperacillin, and ceforanide do not contain this moiety. Testicular degeneration, partially irreversible in nature, was observed with those antibiotics which contain the
N-methyltetrazolethiol substituent. Further, free
N-methyltetrazolethiol also produced testicular degeneration in the juvenile rat. This substituent is most likely responsible for the testicular toxicity observed with cefbuperazone, cefamandole, and cefoperazone in the juvenile rat. The implications of these findings to man are undetermined. |
| doi_str_mv | 10.1016/0272-0590(87)90127-8 |
| format | Article |
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N-methyltetrazolethiol group as the 3-substituent; ampicillin, cefazolin, cefotaxime, cephalothin, cefoxitin, piperacillin, and ceforanide do not contain this moiety. Testicular degeneration, partially irreversible in nature, was observed with those antibiotics which contain the
N-methyltetrazolethiol substituent. Further, free
N-methyltetrazolethiol also produced testicular degeneration in the juvenile rat. This substituent is most likely responsible for the testicular toxicity observed with cefbuperazone, cefamandole, and cefoperazone in the juvenile rat. The implications of these findings to man are undetermined.</description><identifier>ISSN: 0272-0590</identifier><identifier>EISSN: 1095-6832</identifier><identifier>DOI: 10.1016/0272-0590(87)90127-8</identifier><identifier>PMID: 3556839</identifier><identifier>CODEN: FAATDF</identifier><language>eng</language><publisher>Boston, MA: Elsevier Science (USA)</publisher><subject>Aging ; Animals ; Azoles - toxicity ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Male ; Medical sciences ; Organ Size - drug effects ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Structure-Activity Relationship ; Testis - drug effects ; Testis - growth & development ; Testis - pathology ; Tetrazoles - toxicity ; Toxicity: urogenital system</subject><ispartof>Fundamental and applied toxicology, 1987-02, Vol.8 (2), p.280-289</ispartof><rights>1987</rights><rights>1987 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-d57e1f5e06af74275f6dd84e82dda8b1ccf3f8213495b4589a4e7ebe60bc16e73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8193816$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3556839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Comereski, C.R.</creatorcontrib><creatorcontrib>Bregman, C.L.</creatorcontrib><creatorcontrib>Buroker, R.A.</creatorcontrib><title>Testicular toxicity of N-methyltetrazolethiol cephalosporin analogs in the juvenile rat</title><title>Fundamental and applied toxicology</title><addtitle>Fundam Appl Toxicol</addtitle><description>The testicular toxicity of 10 antibiotics was evaluated in juvenile rats. Three of the antibiotics, cefbuperazone, cefamandole, and cefoperazone, contain the
N-methyltetrazolethiol group as the 3-substituent; ampicillin, cefazolin, cefotaxime, cephalothin, cefoxitin, piperacillin, and ceforanide do not contain this moiety. Testicular degeneration, partially irreversible in nature, was observed with those antibiotics which contain the
N-methyltetrazolethiol substituent. Further, free
N-methyltetrazolethiol also produced testicular degeneration in the juvenile rat. This substituent is most likely responsible for the testicular toxicity observed with cefbuperazone, cefamandole, and cefoperazone in the juvenile rat. The implications of these findings to man are undetermined.</description><subject>Aging</subject><subject>Animals</subject><subject>Azoles - toxicity</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organ Size - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Structure-Activity Relationship</subject><subject>Testis - drug effects</subject><subject>Testis - growth & development</subject><subject>Testis - pathology</subject><subject>Tetrazoles - toxicity</subject><subject>Toxicity: urogenital system</subject><issn>0272-0590</issn><issn>1095-6832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PGzEQhi1EBSHtP6DSHhCCw7b2rr_2goRQgUqoXEAcLa933Bg562B7UdNfj9NEOfY0M5pnXtkPQqcEfyOY8O-4EU2NWYcvpLjsMGlELQ_QjOCO1Vy2zSGa7ZFjdJLSK8aEMIqP0FHLWEG6GXp5gpSdmbyOVQ5_nHF5XQVb_aqXkBdrnyFH_Tf4MrjgKwOrhfYhrUJ0Y6XH0v9OVWnzAqrX6R1G56GKOn9Gn6z2Cb7s6hw93_54urmvHx7vft5cP9SGEpHrgQkglgHm2graCGb5MEgKshkGLXtijG2tbEhLO9ZTJjtNQUAPHPeGcBDtHJ1vc1cxvE3lL2rpkgHv9QhhSopQjhteAuaIbkETQ0oRrFpFt9RxrQhWG59qI0ttZCkp1D-fSpazr7v8qV_CsD_aCSz7s91eJ6O9jXo0Lu0xSbpWEl6wqy0GxcW7g6iScTAaGFwEk9UQ3P_f8QEuppMC</recordid><startdate>19870201</startdate><enddate>19870201</enddate><creator>Comereski, C.R.</creator><creator>Bregman, C.L.</creator><creator>Buroker, R.A.</creator><general>Elsevier Science (USA)</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19870201</creationdate><title>Testicular toxicity of N-methyltetrazolethiol cephalosporin analogs in the juvenile rat</title><author>Comereski, C.R. ; Bregman, C.L. ; Buroker, R.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-d57e1f5e06af74275f6dd84e82dda8b1ccf3f8213495b4589a4e7ebe60bc16e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Azoles - toxicity</topic><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organ Size - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Structure-Activity Relationship</topic><topic>Testis - drug effects</topic><topic>Testis - growth & development</topic><topic>Testis - pathology</topic><topic>Tetrazoles - toxicity</topic><topic>Toxicity: urogenital system</topic><toplevel>online_resources</toplevel><creatorcontrib>Comereski, C.R.</creatorcontrib><creatorcontrib>Bregman, C.L.</creatorcontrib><creatorcontrib>Buroker, R.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Fundamental and applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Comereski, C.R.</au><au>Bregman, C.L.</au><au>Buroker, R.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testicular toxicity of N-methyltetrazolethiol cephalosporin analogs in the juvenile rat</atitle><jtitle>Fundamental and applied toxicology</jtitle><addtitle>Fundam Appl Toxicol</addtitle><date>1987-02-01</date><risdate>1987</risdate><volume>8</volume><issue>2</issue><spage>280</spage><epage>289</epage><pages>280-289</pages><issn>0272-0590</issn><eissn>1095-6832</eissn><coden>FAATDF</coden><abstract>The testicular toxicity of 10 antibiotics was evaluated in juvenile rats. Three of the antibiotics, cefbuperazone, cefamandole, and cefoperazone, contain the
N-methyltetrazolethiol group as the 3-substituent; ampicillin, cefazolin, cefotaxime, cephalothin, cefoxitin, piperacillin, and ceforanide do not contain this moiety. Testicular degeneration, partially irreversible in nature, was observed with those antibiotics which contain the
N-methyltetrazolethiol substituent. Further, free
N-methyltetrazolethiol also produced testicular degeneration in the juvenile rat. This substituent is most likely responsible for the testicular toxicity observed with cefbuperazone, cefamandole, and cefoperazone in the juvenile rat. The implications of these findings to man are undetermined.</abstract><cop>Boston, MA</cop><cop>San Diego, CA</cop><cop>New York, NY</cop><pub>Elsevier Science (USA)</pub><pmid>3556839</pmid><doi>10.1016/0272-0590(87)90127-8</doi><tpages>10</tpages></addata></record> |
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| ispartof | Fundamental and applied toxicology, 1987-02, Vol.8 (2), p.280-289 |
| issn | 0272-0590 1095-6832 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; Alma/SFX Local Collection |
| subjects | Aging Animals Azoles - toxicity Biological and medical sciences Drug toxicity and drugs side effects treatment Male Medical sciences Organ Size - drug effects Pharmacology. Drug treatments Rats Rats, Inbred Strains Structure-Activity Relationship Testis - drug effects Testis - growth & development Testis - pathology Tetrazoles - toxicity Toxicity: urogenital system |
| title | Testicular toxicity of N-methyltetrazolethiol cephalosporin analogs in the juvenile rat |
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