Vaccinia virus, herpes simplex virus, and carcinogens induce DNA amplification in a human cell line and support replication of a helpervirus dependent parvovirus

The SV40-transformed human kidney cell line, NB-E, amplifies integrated as well as episomal SV40 DNA upon treatment with chemical (DMBA) or physical (uv irradiation) carcinogens (“initiators”) as well as after infection with herpes simplex virus (HSV) type 1 or with vaccinia virus. In addition it is...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1986-07, Vol.152 (1), p.110-117
Hauptverfasser:	Schlehofer, Jörg R., Ehrbar, Matthias, Hausen, Harald Zur
Format:	Artikel
Sprache:	eng
Schlagworte:	560121 - Radiation Effects on Cells- External Source- (-1987) 560301 - Chemicals Metabolism & Toxicology- Cells- (-1987) 9,10-Dimethyl-1,2-benzanthracene - pharmacology ANIMAL CELLS Applied sciences AROMATICS Biological and medical sciences BIOLOGICAL EFFECTS BODY CARCINOGENS Carcinogens - pharmacology CELL CULTURES Cell Line CHO CELLS CONDENSED AROMATICS Defective Viruses - genetics Dependovirus - genetics DIMETHYLBENZANTHRACENE DNA DNA REPLICATION ELECTROMAGNETIC RADIATION Exact sciences and technology Fundamental and applied biological sciences. Psychology GENE AMPLIFICATION Gene Amplification - drug effects Gene Amplification - radiation effects GENETIC EFFECTS Helper Viruses - genetics herpes simplex virus Humans KIDNEYS Microbiology MICROORGANISMS NUCLEIC ACID REPLICATION NUCLEIC ACIDS ORGANIC COMPOUNDS ORGANS Other techniques and industries PARASITES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Simian virus 40 - genetics Simplexvirus - genetics ULTRAVIOLET RADIATION Ultraviolet Rays VACCINIA VIRUS Vaccinia virus - genetics Virology Virus Replication - drug effects Virus Replication - radiation effects VIRUSES
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